Abstract:
:Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1 with acute necrotizing encephalitis, 2 with pneumonia, and 2 without complications), 5 children with seasonal influenza, and 5 healthy children. We found higher percentages of T-bet(+) CD4(+)CD8(+) T cells, monocytes, and B cells, granzyme B(+) and perforin(+) CD4(+), and CD8(+) T cells in affected children with both seasonal and H1N1 influenza than in controls, whereas both groups demonstrated similar percentages of CD4(+)CD25(+)Foxp3(+) regulatory T cells. In infected children with complications we observed high percentages of perforin(+) and interferon-γ(+) CD4(+) and CD8(+) T cells associated with low percentages of T regulatory cells. Our data suggest a dysregulation of antipathogen type I immune responses in complicated S-OIV infections.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Frisullo G,Iorio R,Plantone D,Nociti V,Patanella AK,Marti A,Palermo C,Valentini P,Mariotti P,Batocchi APdoi
10.1016/j.humimm.2011.04.006subject
Has Abstractpub_date
2011-08-01 00:00:00pages
632-5issue
8eissn
0198-8859issn
1879-1166pii
S0198-8859(11)00096-6journal_volume
72pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00145-6
更新日期:1997-08-01 00:00:00
abstract::Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00200-7
更新日期:2000-11-01 00:00:00
abstract::The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90035-9
更新日期:1989-11-01 00:00:00
abstract::Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients an...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.12.019
更新日期:2012-04-01 00:00:00
abstract::To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(96)00079-1
更新日期:1996-06-01 00:00:00
abstract::Two T4+ cloned T-lymphocyte lines specific for a papain digest product of tetanus toxin are functionally characterized. The two clones were obtained from peripheral blood mononuclear cells activated in vitro by tetanus toxoid, expanded with IL-2, and cloned in soft agar. Both clones could be induced to undergo blastog...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90042-5
更新日期:1987-08-01 00:00:00
abstract::The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.12.006
更新日期:2015-01-01 00:00:00
abstract::The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.12.013
更新日期:2004-03-01 00:00:00
abstract::Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.10.007
更新日期:2006-12-01 00:00:00
abstract::The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)90090-6
更新日期:1994-09-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (alloHCT) is the definitive therapy for numerous otherwise incurable hematologic malignancies and non-malignant diseases. The genetic disparity between donor and recipient both underpins therapeutic effects and confers donor immune system-mediated damage in the recipi...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2019.03.003
更新日期:2019-06-01 00:00:00
abstract:AIMS:We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. PATIENTS AND METHODS:46 IPF patients underwent genotyping, 43 of them had HRCT and 14 patients had a sur...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.07.011
更新日期:2013-10-01 00:00:00
abstract::HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immu...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2020.02.001
更新日期:2020-04-01 00:00:00
abstract::The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.08.345
更新日期:2003-11-01 00:00:00
abstract::Phagocytosis and catabolism of sheep red blood cells by human peripheral blood phagocytes were studied in 100 normal caucasoid subjects (44 males and 56 females). Both phenomena are highly reproducible, and their indices seem to be biological constants. There is no correlation between these two indices and the indices...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90045-3
更新日期:1982-02-01 00:00:00
abstract::The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(83)90065-4
更新日期:1983-02-01 00:00:00
abstract::The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.230
更新日期:2016-10-01 00:00:00
abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00215-4
更新日期:2001-04-01 00:00:00
abstract::As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00431-7
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.10.014
更新日期:2017-02-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00
abstract::Human leukocyte antigen (HLA) antibodies are epitope specific and not antigen specific. This work presents a case of intra-allele (IA) sensitization. A 40-year-old-man underwent transplantion with identical "broad" DR. He was apparently not sensitized to HLA antigens by complement-dependent cytotoxicity (CDC), with on...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.018
更新日期:2010-09-01 00:00:00
abstract::A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.05.004
更新日期:2019-07-01 00:00:00
abstract::A typing system for HLA-D/DR-associated PLT-defined determinants, which have been called "DP" antigens, is reported. Some of the results concerning a data interpretation system, the reproducibility of PLT results, and the correlations between the results of HLA-D, -DR, and DP typing are presented. Also, a "new" human ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90035-5
更新日期:1981-07-01 00:00:00
abstract::The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.02.005
更新日期:2017-04-01 00:00:00
abstract::The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.11.001
更新日期:2008-01-01 00:00:00
abstract::Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90334-j
更新日期:1992-04-01 00:00:00
abstract::CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2019.01.001
更新日期:2019-03-01 00:00:00