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Human T4+ T-lymphocyte clones specific for the B fragment of tetanus toxin.

Abstract：

:Two T4+ cloned T-lymphocyte lines specific for a papain digest product of tetanus toxin are functionally characterized. The two clones were obtained from peripheral blood mononuclear cells activated in vitro by tetanus toxoid, expanded with IL-2, and cloned in soft agar. Both clones could be induced to undergo blastogenesis with tetanus toxoid, tetanus toxin, and the B fragment but not the C fragment of tetanus toxin. In addition, both clones caused cytolysis of plastic adherent cell targets cocultured for 18 hr with either tetanus or the B fragment. Antigen specific proliferation and cytolytic activity were MHC-class I restricted.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Scrivner D,Kristof S,Rodey G

doi

10.1016/0198-8859(87)90042-5

subject

Has Abstract

pub_date

1987-08-01 00:00:00

pages

245-54

issue

4

eissn

0198-8859

issn

1879-1166

pii

0198-8859(87)90042-5

journal_volume

19

pub_type

杂志文章

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