Abstract：
:A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 2.26%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Nicaragua Mestizo" and the identifier AFN3610.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Arrieta-Bolaños E,Madrigal-Sánchez JJ,Stein JE,Moreira-Espinoza MJ,Paredes-Carias E,Vanegas-Padilla Y,Salazar-Sánchez L,Madrigal JA,Marsh SGE,Shaw BEdoi
10.1016/j.humimm.2019.05.004subject
Has Abstractpub_date
2019-07-01 00:00:00pages
417-418issue
7eissn
0198-8859issn
1879-1166pii
S0198-8859(19)30457-4journal_volume
80pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:The modified mixed leukocyte reaction (MMLR) test consists of the standard MLR (SMLR) test to which interleukin-4 (IL-4) has been added. It is a sensitive procedure capable of detecting alloreactivity not detected by the SMLR. In the present study we applied the MMLR test to unrelated bone marrow transplantation (BMT)...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00065-8
更新日期：1999-09-01 00:00:00
abstract：:T-cell clonal anergy induced by peptide analogs in the presence of live APC in murine systems was reported to be associated with incomplete tyrosine phosphorylation of the CD3 zeta chain followed by a lack of subsequent ZAP-70 recruitment. Furthermore, protein tyrosine phosphatase SHP-1 was associated with ZAP-70 upon...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/S0198-8859(96)00273-X
更新日期：1997-03-01 00:00:00
abstract：:Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.04.024
更新日期：2013-08-01 00:00:00
abstract：:RING 11, a second transport-associated gene (TAP2), has been recently identified in the DR-DP interval of the human class II region. Two predominant alleles, TAP2A and TAP2B, differing by 17 amino acids at the C-terminus of the ATP-binding domain are present in the Caucasoid population at frequencies of 79% and 21%, r...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90544-b
更新日期：1993-11-01 00:00:00
abstract：:Using a large battery of Bw16, w38, and w39 antisera, a new variant of Bw16 has been identified in four unrelated Mexican-American families. The serologic pattern obtained is distinct from that for Bw38, Bw39, and 8W57 antigens. Absorption studies confirm the existence of this new Bw16 subtype which we term ST-16. ST-...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(82)90050-7
更新日期：1982-02-01 00:00:00
abstract：:Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.05.002
更新日期：2011-09-01 00:00:00
abstract：:DOCK10 is a member of the dedicator of cytokinesis (DOCK) family of Rho GTPase activators preferentially expressed in lymphocytes. In this paper, we analyzed DOCK10 mRNA diversity produced because of alternative splicing. Alternative first coding exon usage led to 2 main protein-coding transcripts, DOCK10.1 and DOCK10...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.03.024
更新日期：2011-07-01 00:00:00
abstract：:Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.02.005
更新日期：2017-04-01 00:00:00
abstract：:Few data are available concerning immune factors involved in the occurrence of new onset diabetes after transplantation (NODAT). Our objective was to determine an immune profile associated with the subsequent development of NODAT. The secondary objective was to build a predictive model of NODAT. We studied a prospecti...
journal_title：Human immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.humimm.2019.08.006
更新日期：2019-11-01 00:00:00
abstract：:The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(88)90071-7
更新日期：1988-03-01 00:00:00
abstract：:The aim of this study was to assess the possible association of the functional (GT)(n) microsatellite polymorphism in the FOXP3 gene with predisposition to several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease, and celiac disease. We...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.06.001
更新日期：2005-08-01 00:00:00
abstract：:One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(00)00151-8
更新日期：2000-09-01 00:00:00
abstract：:In an attempt to develop a suitable model for increasing the yield of human anti-HLA mAbs, we have used mice with SCID for i.p. injection of two human-mouse heterohybridomas. HMP1 hybridoma secretes a DQB1*0201 allele-specific human mAb whereas HMP12 secretes a human mAb recognizing the DRB1*1101, 1102, 1103, and 1104...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(92)90008-b
更新日期：1992-12-01 00:00:00
abstract：:The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90090-6
更新日期：1994-09-01 00:00:00
abstract：:Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.06.007
更新日期：2018-09-01 00:00:00
abstract：:The suppressive effects of CD4+CD25+ regulatory T cells (Tregs) on T cells have been well documented. Here we investigated whether human CD4+CD25+ Tregs can inhibit the proinflammatory properties of monocytes/macrophages. Monocytes and T cells were isolated from peripheral blood of healthy volunteers by magnetic cell ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2004.12.006
更新日期：2005-03-01 00:00:00
abstract：:The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2004.03.003
更新日期：2004-06-01 00:00:00
abstract：:Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal. HLA-...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.01.010
更新日期：2011-04-01 00:00:00
abstract：:The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.11.001
更新日期：2008-01-01 00:00:00
abstract：:Cell-mediated cytotoxicity involves a localized secretory process in which lytic agents stored in specialized granules of the effector cells are released upon contact with the appropriate target cell membrane and cause membrane damage. The protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP) inhibits cytotoxici...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(88)90039-0
更新日期：1988-06-01 00:00:00
abstract：:It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.05.002
更新日期：2013-11-01 00:00:00
abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(81)90044-6
更新日期：1981-08-01 00:00:00
abstract：:The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area has been limited, however, since CTL recognize minor alloantigens only in association with self-class I antigens. Thus, experiments designed to study minor all...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(87)90035-8
更新日期：1987-05-01 00:00:00
abstract：:Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.06.001
更新日期：2019-10-01 00:00:00
abstract：:The expression of the Duffy Antigen/Receptor for Chemokines (DARC) on red blood cells (RBC) has been commonly determined using hemagglutination tests. Because the vast majority of African individuals are Duffy-negative, screening for DARC expression on RBC is a valuable tool to assess Caucasian admixture in population...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00039-7
更新日期：1999-08-01 00:00:00
abstract：:Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.03.005
更新日期：2016-05-01 00:00:00
abstract：:LEW strain rats received BN strain renal allografts and were treated with daily injections of 100 micrograms BWH-4, a new IgG2a mouse anti-rat CD4 monoclonal antibody, intravenously for 5 to 10 days. These animals had a median actuarial survival of 28 days. Control animals rejected their grafts and died of uremia betw...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90098-0
更新日期：1989-10-01 00:00:00
abstract：:The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of He...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.07.003
更新日期：2016-10-01 00:00:00
abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.07.012
更新日期：2009-10-01 00:00:00
abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(87)90018-8
更新日期：1987-12-01 00:00:00
