HLA-and Gm-linked genes affecting the degradation rate of antigens (sheep red blood cells) endocytized by macrophages.

abstract：:LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...

journal_title：Human immunology

authors： Song L,Ma N,Han L,Yan H,Yan B,Yuan Z,Cao B

更新日期：2014-03-01 00:00:00

abstract：:Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...

journal_title：Human immunology

authors： Lee KW,Jung YA

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:The aims of this study were to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of asthma and to generate SNP to gene to pathway hypotheses. METHODS:SNPs that met a threshold of p ≤ 0.001 in a genome-wide association study (GWAS) dataset of asthma, which in...

journal_title：Human immunology

authors： Song GG,Lee YH

更新日期：2013-02-01 00:00:00

abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

journal_title：Human immunology

authors： Macardle PJ,Wheatland L,Zola H

更新日期：1999-02-01 00:00:00

abstract：:A role of CD4(+) cells in the regulation of immune responses has steadily gained renewed recognition. The understanding of these T-regulatory (T-reg) cells in the generation of antitumor cytolytic T lymphocyte (CTL) response is therefore important. It has been shown that immunization with specific peptides, DNA, or tu...

journal_title：Human immunology

authors： Chakraborty NG,Chattopadhyay S,Mehrotra S,Chhabra A,Mukherji B

更新日期：2004-08-01 00:00:00

abstract：:Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...

journal_title：Human immunology

authors： Castro-Santos P,Verdugo RA,Díaz-Peña R

更新日期：2018-09-01 00:00:00

abstract：:The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...

journal_title：Human immunology

authors： Cho SM,Kim J,Ryu HJ,Kim JJ,Kim HH,Park JH,Kim HT,Kim KH,Cho HY,Oh B,Park C,Kimm K,Jo I,Lee JE,Shin HD,Lee JK

更新日期：2004-07-01 00:00:00

abstract：:Comparison of human leukocyte antigen (HLA) frequencies in patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and in patients with HCV-associated non-Hodgkin's lymphoma (NHL) has not been addressed previously. To this aim, we investigated the distribution of HLA class II alleles in two sel...

journal_title：Human immunology

authors： De Re V,Caggiari L,Talamini R,Crovatto M,De Vita S,Mazzaro C,Cannizzaro R,Dolcetti R,Boiocchi M

更新日期：2004-11-01 00:00:00

abstract：:The aim of this study was to test whether the functional variant rs2076530 of the BTNL2 gene confers susceptibility to the autoimmune diseases type 1 diabetes (T1D), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Our study populations consisted of 326 patients with T1D and 351 healthy subjects, 808...

journal_title：Human immunology

authors： Orozco G,Eerligh P,Sánchez E,Zhernakova S,Roep BO,González-Gay MA,López-Nevot MA,Callejas JL,Hidalgo C,Pascual-Salcedo D,Balsa A,González-Escribano MF,Koeleman BP,Martín J

更新日期：2005-12-01 00:00:00

abstract：:Idiopathic achalasia is an esophageal motor disorder of unknown etiology. A wealth of evidence supports the concept that achalasia is an immune-mediated disease. According to this evidence, achalasia has been significantly associated with specific alleles of the human leukocyte antigen class II, PTPN22 and IL23R. Seve...

journal_title：Human immunology

authors： Nuñez C,García-González MA,Santiago JL,Benito MS,Mearín F,de la Concha EG,de la Serna JP,de León AR,Urcelay E,Vigo AG

更新日期：2011-09-01 00:00:00

abstract：:T lymphoblasts sensitized in vitro to tetanus toxoid (TT) in 6 day cultures, acquire the capacity of stimulating the blastogenic response of "resting" autologous T lymphocytes in primary AMLC reactions. The response of lymphocytes primed against autologous-TT-sensitized-lymphoblasts (ATTSL) seems to be specific for id...

journal_title：Human immunology

authors： Suciu-Foca N,Rohowsky C,Kung P,King DW

更新日期：1984-01-01 00:00:00

abstract：:The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune mo...

journal_title：Human immunology

authors： Persson G,Jørgensen N,Nilsson LL,Andersen LHJ,Hviid TVF

更新日期：2020-04-01 00:00:00

abstract：:The MHC in humans is a much studied region of the genome, the genes of which display a high rate of polymorphism and a high rate of linkage disequilibrium. Four families in which intra-class-I recombination has occurred have been analyzed with six polymorphic markers between HLA-A and -B in order to determine the full...

journal_title：Human immunology

authors： Crouau-Roy B,Bouissou C,Sommer E,Pontarotti P,Thomsen M

更新日期：1993-10-01 00:00:00

abstract：:More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...

journal_title：Human immunology

authors： Dankers MK,Roelen DL,Korfage N,de Lange P,Witvliet M,Sandkuijl L,Doxiadis II,Claas FH

更新日期：2003-06-01 00:00:00

abstract：:Rearrangements of the T-cell Rearranging Gene (TRG) or T-cell-receptor gamma-chain genes were analyzed in 24 in vivo-sensitized alloreactive T-cell clones. This analysis represents the first complete assignment of TRG gene rearrangements to given variable and joining gene segments in nonleukemic T cells and provides s...

journal_title：Human immunology

authors： Moisan JP,Bonneville M,Bouyge I,Moreau JF,Soulillou JP,Lefranc MP

更新日期：1989-02-01 00:00:00

abstract：:A reliable method for high-resolution HLA-DQB1 typing using a combination of PCR- restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism (SSCP) analysis is described. The second exon of the DQB1 gene was subjected to PCR using generic primers and digested with two restriction e...

journal_title：Human immunology

authors： Park MH,Whang DH,Kang SJ

更新日期：1999-09-01 00:00:00

abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

journal_title：Human immunology

authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

更新日期：1990-02-01 00:00:00

abstract：:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...

journal_title：Human immunology

authors： Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

更新日期：1990-03-01 00:00:00

abstract：:Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the chi...

journal_title：Human immunology

authors： Reed EF,Tugulea SL,Suciu-Foca N

更新日期：1994-06-01 00:00:00

abstract：:In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

journal_title：Human immunology

authors： Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

更新日期：1989-12-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...

journal_title：Human immunology

authors： Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

更新日期：2014-06-01 00:00:00

abstract：:The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

journal_title：Human immunology

authors： Zachary AA,Delaney NL,Lucas DP,Leffell MS

更新日期：2001-03-01 00:00:00

abstract：:Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellu...

journal_title：Human immunology

authors： Singh B,Anbalagan S,Selvaraj P

更新日期：2017-01-01 00:00:00

abstract：:The T-helper 1 (Th1) immune reaction is most important in dendritic cell (DC)-based immunotherapy. Interleukin (IL)-18, a Th1-biasing cytokine, plays a pivotal role in inducing cytotoxic T lymphocyte (CTL) responses. In this study, we analyzed whether dendritic cells (DCs) from patients with hepatocellular carcinoma (...

journal_title：Human immunology

authors： Cao DY,Yang JY,Dou KF,Ma LY,Teng ZH

更新日期：2007-05-01 00:00:00

abstract：:In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...

journal_title：Human immunology

authors： Poland GA,Jacobson RM

更新日期：2012-08-01 00:00:00

abstract：:Resident macrophages are mainly responsible for the clearance of apoptotic cells from tissue by phagocytosis. Phagocytosis of apoptotic cells is not accompanied by activation of inflammatory mechanisms, unlike what happens when necrotic phenomena occur. We analyzed the effect of phagocytosis of apoptotic bodies on mac...

journal_title：Human immunology

authors： Filaci G,Contini P,Fravega M,Fenoglio D,Azzarone B,Julien-Giron M,Fiocca R,Boggio M,Necchi V,De Lerma Barbaro A,Merlo A,Rizzi M,Ghio M,Setti M,Puppo F,Zanetti M,Indiveri F

更新日期：2003-01-01 00:00:00

abstract：:Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

journal_title：Human immunology

authors： Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

更新日期：2001-02-01 00:00:00

abstract：:The HER-2/neu protein is overexpressed in approximately 20% of human adenocarcinomas and is a defined tumor antigen in breast cancer. The purpose of this study was to evaluate the endogenous HER-2/neu specific antibody response in 57 patients with colorectal cancer. HER-2/neu specific antibodies, titer > or = 1:100, w...

journal_title：Human immunology

authors： Ward RL,Hawkins NJ,Coomber D,Disis ML

更新日期：1999-06-01 00:00:00

abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

journal_title：Human immunology

authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

更新日期：2002-09-01 00:00:00

abstract：:Serological identification of a new HLA-Bw16 subtype, B39B, was made by the analysis of reaction patterns of many alloantisera and one monoclonal antibody. The B39B pattern of reactivity was shown to be distinct from HLA-Bw38, Bw39, and 8w57. Cytotoxicity testing before and after absorption suggests that the B39B spec...

journal_title：Human immunology

authors： Williams E,Alonso A,Doyle P,Okoye R,Ollier W,Festenstein H

更新日期：1985-09-01 00:00:00