当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer.

Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with epithelial ovarian cancer.

Abstract：

:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand genes with the incidence and clinical course of epithelial ovarian cancer. DNA of 142 patients was analyzed for KIR genes and 103 samples were typed for HLA class I. Control group consisted of 200 healthy individuals, including 83 women, analyzed separately. The frequency of KIR genes in patients and controls were comparable. HLA-C group 1 (ligand for KIR2DL2/3) was more frequent in patients than in controls (86.4% vs. 67.5%, p=0.002). The frequency of KIR2DS4fl was higher in patients with endometrioid cancer (72.3%) compared with other histological subtypes (36.5%, p=0.004) and controls (29.5%, p=0.0001). KIR and KIR ligand genotype did not influence significantly the clinical course of the disease. We conclude that the genotype of KIR ligands is strongly associated with the incidence of epithelial ovarian cancer while KIR2DS4fl confers susceptibility to endometrioid subtype of the disease.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

doi

10.1016/j.humimm.2014.04.002

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

508-13

issue

6

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(14)00113-X

journal_volume

75

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Interleukin-6 gene variants and the risk of sepsis development in children.

    abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.06.003

    authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

    更新日期：2007-09-01 00:00:00

  • Coexistence of an MHC chromosomal segment marked by HLA B17,BfS,C4A6,B1,DR7, and DQw9 in different ethnic groups.

    abstract：:Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(88)90015-8

    authors： Kay PH,Dawkins RL,Williamson J,Tokunaga K,Christiansen FT,Charoenwong P

    更新日期：1988-09-01 00:00:00

  • Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.

    abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.12.007

    authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

    更新日期：2018-02-01 00:00:00

  • HLA gene haplotype frequencies in bone marrow donors worldwide registries.

    abstract：:To calculate reliable HLA gene and haplotype frequencies of bone marrow donors in various regions in the world, we have analyzed the HLA-A, -B, and -DR phenotype frequencies of 18 bone marrow donor registries with a total of more than 300,000 HLA-A, -B-typed donors. These registries were included in the 22nd edition o...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(96)00257-1

    authors： Schipper RF,D'Amaro J,Bakker JT,Bakker J,van Rood JJ,Oudshoorn M

    更新日期：1997-01-01 00:00:00

  • Autoreactive T cells from a type I diabetic recognize multiple class II products.

    abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(93)90128-n

    authors： Miller G,Nepom GT,Reich MB,Thomas JW

    更新日期：1993-04-01 00:00:00

  • The influence of the hinge region length in binding of human IgG to human Fcgamma receptors.

    abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00075-5

    authors： Redpath S,Michaelsen TE,Sandlie I,Clark MR

    更新日期：1998-11-01 00:00:00

  • GvHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model.

    abstract：:This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00324-x

    authors： Dickinson AM,Cavet J,Cullup H,Wang XN,Sviland L,Middleton PG

    更新日期：2001-11-01 00:00:00

  • TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

    abstract：INTRODUCTION:Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, a...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.09.007

    authors： Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

    更新日期：2013-01-01 00:00:00

  • HLA-G regulatory haplotypes and implantation outcome in couples who underwent assisted reproduction treatment.

    abstract：:The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.06.002

    authors： Costa CH,Gelmini GF,Wowk PF,Mattar SB,Vargas RG,Roxo VM,Schuffner A,Bicalho Mda G

    更新日期：2012-09-01 00:00:00

  • Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.

    abstract：:The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.04.005

    authors： Cho SM,Kim J,Ryu HJ,Kim JJ,Kim HH,Park JH,Kim HT,Kim KH,Cho HY,Oh B,Park C,Kimm K,Jo I,Lee JE,Shin HD,Lee JK

    更新日期：2004-07-01 00:00:00

  • A study of HLA-B∗15:02 in a Sri Lankan population: Implications for pharmacogenomic testing.

    abstract：:HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.04.001

    authors： Gunathilake KM,Wettasinghe KT,Dissanayake VH

    更新日期：2016-05-01 00:00:00

  • Restriction fragment length polymorphism in HLA class II genes of Latin-American Caucasian celiac disease patients.

    abstract：:In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90005-0

    authors： Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

    更新日期：1989-12-01 00:00:00

  • Enhanced expression of HLA-class II molecules on activated human T lymphocytes following treatment with tumor necrosis factor alpha.

    abstract：:Many factors induce or enhance expression of major histocompatibility complex class I and class II molecules on various cell types. Human T lymphocytes are class II negative in the resting state but show expression of class II molecules following activation. We analyzed the modulating capacity of the lymphokines recom...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90101-e

    authors： Diedrichs-Möhring M,Epplen JT,Schendel DJ

    更新日期：1991-08-01 00:00:00

  • Typing for human alloantigens with the primed lymphocyte typing (PLT) technique with notes on the interpretation of PLT data.

    abstract：:A typing system for HLA-D/DR-associated PLT-defined determinants, which have been called "DP" antigens, is reported. Some of the results concerning a data interpretation system, the reproducibility of PLT results, and the correlations between the results of HLA-D, -DR, and DP typing are presented. Also, a "new" human ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(81)90035-5

    authors： Morling N,Jakobsen BK,Platz P,Ryder LP,Svejgaard A,Thomsen M

    更新日期：1981-07-01 00:00:00

  • TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.

    abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)00124-9

    authors： Jackson DG,Capra JD

    更新日期：1995-05-01 00:00:00

  • Responses in vitro of peripheral blood lymphocytes from patients with myasthenia gravis to stimulation with human acetylcholine receptor alpha-chain peptides: analysis in relation to age, thymic abnormality, and ethnicity.

    abstract：:Peripheral blood lymphocytes (PBLs) were isolated from 24 patients with myasthenia gravis of three ethnic groups (Caucasian, African American, and Hispanic) and ten healthy individuals. We determined the in vitro proliferative responses of the PBL samples to each of 18 overlapping synthetic peptides corresponding to t...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.09.015

    authors： Oshima M,Deitiker PR,Mosier DR,Smith RG,Atassi MZ

    更新日期：2005-01-01 00:00:00

  • Effect of delayed graft function in hypersensitized kidney transplant recipients.

    abstract：:There is increased evidence about the deleterious effect of delayed graft function (DGF) in both short- and long-term kidney graft outcome. Among the mechanisms involved in the production of DGF, immune factors play a role, especially in the level of hypersensitization. From the 1389 patients transplanted at our hospi...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2005.01.026

    authors： López-Hoyos M,Fernández-Fresnedo G,Rodrigo E,Ruiz JC,Arias M

    更新日期：2005-04-01 00:00:00

  • Lack of an association between interleukin-6 gene promoter polymorphisms (-174G/C, -572G/C) and ischemic heart disease and/or ischemic stroke: a meta-analysis.

    abstract：:The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous. In this study, we performed a more precise estimation of the relationship by a ...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2011.03.019

    authors： Ma Y,Tang RK,Yang X,Peng GG,Liu Y,Wang XM,Wu BH,Yu JM

    更新日期：2011-08-01 00:00:00

  • HLA-DRw52a is involved in alloimmunization against PL-A1 antigen.

    abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90104-w

    authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

    更新日期：1990-02-01 00:00:00

  • TAP1 and TAP2 gene polymorphisms and HLA-TAP haplotypes in Koreans based on 90 families.

    abstract：:We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2005.07.001

    authors： Whang DH,Park H,Roh EY,Park MH

    更新日期：2005-09-01 00:00:00

  • CD8+ suppressor T cells resurrected.

    abstract：:This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2008.07.018

    authors： Kapp JA,Bucy RP

    更新日期：2008-11-01 00:00:00

  • Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco.

    abstract：:To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00370-6

    authors： Oumhani K,Canossi A,Piancatelli D,Di Rocco M,Del Beato T,Liberatore G,Aureli A,Benjoaud A,El Aouad R,Adorno D,Casciani CU

    更新日期：2002-02-01 00:00:00

  • Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells.

    abstract：:During T-cell maturation, thymocytes interact with thymic stromal major histocompatibility complex (MHC) determinants and thymic hormones, and proliferate, apparently in response to MHC gene products, in the absence of antigen. The maturing thymocytes also express a series of cell surface molecules, at one stage coexp...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(86)90304-6

    authors： Richardson B

    更新日期：1986-12-01 00:00:00

  • Association between human leukocyte antigen class I and II alleles and hepatitis C virus infection in high-risk hemodialysis patients awaiting kidney transplantation.

    abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.008

    authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

    更新日期：2013-12-01 00:00:00

  • Simultaneous HLA Class I and Class II antibodies screening with flow cytometry.

    abstract：:A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class I and 30 different Class II microbeads coated with purified HLA antigens. The antibodies in the serum that react specifically to the coated HLA antigens ar...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00020-2

    authors： Pei R,Wang G,Tarsitani C,Rojo S,Chen T,Takemura S,Liu A,Lee J

    更新日期：1998-05-01 00:00:00

  • Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy.

    abstract：:The aim of this work was to investigate the longitudinal evolution of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G. Blood samples were obtained from 45 volunteers during normal pregnancy, 8 of them monthl...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.04.007

    authors： Alegre E,Díaz-Lagares A,Lemaoult J,López-Moratalla N,Carosella ED,González A

    更新日期：2007-08-01 00:00:00

  • A comprehensive polymerase chain reaction-oligonucleotide typing system for the HLA class I A locus.

    abstract：:A comprehensive system for genetic typing of the HLA class I A locus is described, based on PCR amplification and typing with nonradioactively labeled SSO probes. Exons 1-3 of the A locus are amplified and typing is performed with a set of 30 nonradioactively labeled oligonucleotide probes. This system resolves 34 of ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)90018-3

    authors： Allen M,Liu L,Gyllensten U

    更新日期：1994-05-01 00:00:00

  • Haplotype analysis of killer cell immunoglobulin-like receptor genes in 77 Korean families.

    abstract：:Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.10.013

    authors： Whang DH,Park H,Yoon JA,Park MH

    更新日期：2005-02-01 00:00:00

  • Association of LRP5, TCF7L2, and GCG variants and type 2 diabetes mellitus as well as fasting plasma glucose and lipid metabolism indexes.

    abstract：:Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2015.03.005

    authors： Wang J,Yan G,Zhang J,Gao K,Zhang M,Li L,Wang Y,Wang Q,Zhai Y,You H,Ren Y,Wang B,Hu D

    更新日期：2015-05-01 00:00:00

  • Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-alpha and ribavirin treatment for chronic hepatitis C virus infection.

    abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(03)00041-7

    authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

    更新日期：2003-05-01 00:00:00