Effect of delayed graft function in hypersensitized kidney transplant recipients.


:There is increased evidence about the deleterious effect of delayed graft function (DGF) in both short- and long-term kidney graft outcome. Among the mechanisms involved in the production of DGF, immune factors play a role, especially in the level of hypersensitization. From the 1389 patients transplanted at our hospital until November 2004, it has been found that the presence of moderate and high levels of sensitization, as measured by panel-reactive antibodies, is a risk factor for suffering from DGF. Further, DGF was associated with poor graft survival, and the risk was even higher when DGF was combined with moderate/high panel-reactive antibodies. Recent data demonstrate the usefulness of intravenous immunoglobulins in the management of hypersensitized patients in terms of short-term outcome. It remains to be demonstrated whether this therapy is able to ameliorate the higher ischemic injury that kidneys undergo from these immunologically high-risk patients.


Hum Immunol


Human immunology


López-Hoyos M,Fernández-Fresnedo G,Rodrigo E,Ruiz JC,Arias M




Has Abstract


2005-04-01 00:00:00














  • Frequencies of gene variant CCR5-Δ32 in 87 countries based on next-generation sequencing of 1.3 million individuals sampled from 3 national DKMS donor centers.

    abstract::Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5 (CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) and therefore preferred stem cell donors for HIV-infected patients. We analyzed CCR5 typing data of 1,333,035 potential hematopoietic stem cell don...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Solloch UV,Lang K,Lange V,Böhme I,Schmidt AH,Sauter J

    更新日期:2017-11-01 00:00:00

  • Association of KCNQ1 and KLF14 polymorphisms and risk of type 2 diabetes mellitus: A global meta-analysis.

    abstract::rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 20...

    journal_title:Human immunology

    pub_type: 杂志文章,meta分析


    authors: Wang J,Zhang J,Shen J,Hu D,Yan G,Liu X,Xu X,Pei L,Li Y,Sun C

    更新日期:2014-04-01 00:00:00

  • Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.

    abstract::Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

    更新日期:2004-04-01 00:00:00

  • A clonal culture assay for human cord blood lymphohematopoietic progenitors.

    abstract::We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

    更新日期:1999-01-01 00:00:00

  • Allele polymorphism and haplotype diversity of MICA/B in Tujia nationality of Zhangjiajie, Hunan Province, China.

    abstract::Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Wang YJ,Zhang NJ,Chen E,Chen CJ,Bu YH,Yu P

    更新日期:2016-05-01 00:00:00

  • The genetic structure of Mexican Mestizos of different locations: tracking back their origins through MHC genes, blood group systems, and microsatellites.

    abstract::Mexican Mestizos, who are the result of the admixture of Spanish, Indian, and Black genes, were analyzed for different systems. Three populations from geographical distinct areas were studied: the north (State of Nuevo Leon ), the center (State of Guanajuato), and the highlands (mainly Mexico City). Ten blood group sy...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Gorodezky C,Alaez C,Vázquez-García MN,de la Rosa G,Infante E,Balladares S,Toribio R,Pérez-Luque E,Muñoz L

    更新日期:2001-09-01 00:00:00

  • Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma.

    abstract::A role of CD4(+) cells in the regulation of immune responses has steadily gained renewed recognition. The understanding of these T-regulatory (T-reg) cells in the generation of antitumor cytolytic T lymphocyte (CTL) response is therefore important. It has been shown that immunization with specific peptides, DNA, or tu...

    journal_title:Human immunology

    pub_type: 临床试验,杂志文章


    authors: Chakraborty NG,Chattopadhyay S,Mehrotra S,Chhabra A,Mukherji B

    更新日期:2004-08-01 00:00:00

  • Specific nature of cellular immune responses elicited by chimpanzees against HIV-1.

    abstract::Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage o...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Balla-Jhagjhoorsingh SS,Verschoor EJ,de Groot N,Teeuwsen VJ,Bontrop RE,Heeney JL

    更新日期:2003-07-01 00:00:00

  • Prediction of spurious HLA class II typing results using probabilistic classification.

    abstract::While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Schöfl G,Schmidt AH,Lange V

    更新日期:2016-03-01 00:00:00

  • Increased RUNX1 expression in patients with immune thrombocytopenia.

    abstract::Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Zhong X,Wu Y,Liu Y,Zhu F,Li X,Li D,Li Z,Zeng L,Qiao J,Chen X,Xu K

    更新日期:2016-08-01 00:00:00

  • Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival.

    abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Vlad G,Ho EK,Vasilescu ER,Colovai AI,Stokes MB,Markowitz GS,D'Agati VD,Cohen DJ,Ratner LE,Suciu-Foca N

    更新日期:2009-08-01 00:00:00

  • Lymphocytes induce enhanced expression of HLA class I antigens on cytomegalovirus-infected syngeneic human endothelial cells.

    abstract::Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultured endothelial cells and cocultured ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Scholz M,Blaheta RA,Cinatl J,Encke A,Doerr HW,Markus BH

    更新日期:1995-11-01 00:00:00

  • Narcolepsy without unique MHC class II antigen association: studies in the canine model.

    abstract::Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Dean RR,Kilduff TS,Dement WC,Grumet FC

    更新日期:1989-05-01 00:00:00

  • Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry.

    abstract::We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Gragert L,Madbouly A,Freeman J,Maiers M

    更新日期:2013-10-01 00:00:00

  • Di-allelic alloantigenic systems on subsets of T cells.

    abstract::Sera obtained from multiparous women and some of other origin contain antibodies which react with antigens on T cell subsets. These antibodies recognize two distinct diallelic systems, one of which is mainly present on T gamma cells while the other is present on T mu cells. The sera that reacted with the T gamma cells...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: van Leeuwen A,Festenstein H,van Rood JJ

    更新日期:1982-04-01 00:00:00

  • Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasia.

    abstract::This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: da Silva RF,Petta CA,Derchain SF,Alici E,Guimarães F

    更新日期:2014-08-01 00:00:00

  • Genetic susceptibility to multiple sclerosis: detection of polymorphic nucleotides and an intron in the 3' untranslated region of the major histocompatibility complex class II transactivator gene.

    abstract::The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Rasmussen HB,Kelly MA,Clausen J

    更新日期:2001-04-01 00:00:00

  • Toll like receptors in self-recovering hepatitis E patients with or without pregnancy.

    abstract::Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The patient categories in...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Arya RP,Arankalle VA

    更新日期:2014-12-01 00:00:00

  • Anti-HLA-B7,B27,Bw42,Bw54,Bw55,Bw56, Bw67,Bw73 monoclonal antibodies: specificity, idiotypes, and application for a double determinant immunoassay.

    abstract::The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Sakaguchi K,Ono R,Tsujisaki M,Richiardi P,Carbonara A,Park MS,Tonai R,Terasaki PI,Ferrone S

    更新日期:1988-03-01 00:00:00

  • A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents.

    abstract::The HLA-DQA1*05 with DQB1*02 alleles are a major risk factor for celiac disease (CD). To search for additional human leukocyte antigen (HLA) risk factors, we looked on the DR3-DQ2 risk haplotype, selected because it carries both DQ risk alleles in cis and is the more represented among CD patients. In a European consor...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Louka AS,Moodie SJ,Karell K,Bolognesi E,Ascher H,Greco L,Momigliano-Richiardi P,Partanen J,Ciclitira PJ,Sollid LM,European Genetics Cluster on Celiac Disease.

    更新日期:2003-03-01 00:00:00

  • The influence of the hinge region length in binding of human IgG to human Fcgamma receptors.

    abstract::Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Redpath S,Michaelsen TE,Sandlie I,Clark MR

    更新日期:1998-11-01 00:00:00

  • Modulation of glucocorticoid receptor induction properties by cofactors in peripheral blood mononuclear cells.

    abstract::Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Luo M,Simons SS Jr

    更新日期:2009-10-01 00:00:00

  • Transmission of HLA-DP variants from parents to children with B-cell precursor acute lymphoblastic leukemia: log-linear analysis using the case-parent design.

    abstract::Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Taylor M,Bergemann TL,Hussain A,Thompson PD,Spector L

    更新日期:2011-10-01 00:00:00

  • MUC1 is a novel costimulatory molecule of human T cells and functions in an AP-1-dependent manner.

    abstract::MUC1 mucin, primarily known as an epithelial antigen, has been demonstrated to be expressed on activated human T cells. In the present study, we first examined the expression of MUC1 on different subsets of T cells (naive, effector, effector/memory). MUC1 appears to be strongly upregulated on activated CD4(+) T cells ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Konowalchuk JD,Agrawal B

    更新日期:2012-05-01 00:00:00

  • HLA-DRw52a is involved in alloimmunization against PL-A1 antigen.

    abstract::The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

    更新日期:1990-02-01 00:00:00

  • HLA class II-restricted binding of muramyl peptides to B lymphocytes of normal and narcoleptic subjects.

    abstract::The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

    更新日期:1990-03-01 00:00:00

  • Uniparental maternal disomy 6 in a renal transplant patient.

    abstract::HLA analysis of the family of a renal transplant patient revealed an extremely rare condition. On repeated typings the only demonstrable HLA antigens shown in the propositus were from the maternal haplotype, HLA-A11,-B46,-CW1,-DR14,-DQ1. No paternal antigens could be demonstrated either by serologic or by DNA-typing m...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: van den Berg-Loonen EM,Savelkoul P,van Hooff H,van Eede P,Riesewijk A,Geraedts J

    更新日期:1996-01-01 00:00:00

  • Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides.

    abstract::The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Jugdé F,Boissier C,Birebent B,Vu N,D'halluin PN,Rioux-Leclercq N,Bretagne JF,Semana G,Heresebach D

    更新日期:2004-03-01 00:00:00

  • Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.

    abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...

    journal_title:Human immunology

    pub_type: 杂志文章,评审


    authors: Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M

    更新日期:2018-03-01 00:00:00

  • Streptococcus pyogenes type 5 M protein is an antigen, not a superantigen, for human T cells.

    abstract::M proteins are coiled-coil dimers expressed on group A streptococcal cell surfaces. They have an important role in host antistreptococcal immunity and in poststreptococcal autoimmune sequelae. Controversy has arisen regarding whether type 5 M proteins are superantigenic for human T cells. To investigate this, we have ...

    journal_title:Human immunology

    pub_type: 杂志文章


    authors: Degnan B,Taylor J,Hawkes C,O'Shea U,Smith J,Robinson JH,Kehoe MA,Boylston A,Goodacre JA

    更新日期:1997-04-01 00:00:00