Gene products of the HLA-D region in normal and malignant tissues of nonlymphoid origin.

abstract：:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...

journal_title：Human immunology

authors： Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

更新日期：1990-03-01 00:00:00

abstract：:In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...

journal_title：Human immunology

authors： Ottenhoff TH,Elferink DG,Hermans J,de Vries RR

更新日期：1985-06-01 00:00:00

abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...

journal_title：Human immunology

authors： Miller G,Nepom GT,Reich MB,Thomas JW

更新日期：1993-04-01 00:00:00

abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

journal_title：Human immunology

authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

更新日期：1999-11-01 00:00:00

abstract：:CD8-positive γδ T lymphocytes (GDCD8(+)) are specifically increased in peripheral blood of Behçet's disease (BD) patients. GDCD8(+) have shown a T regulatory (Treg) function in autoimmune experimental models, human tumor infiltrates and intestinal intraepithelial lymphocytes from celiac patients. The aim of this study...

journal_title：Human immunology

authors： Clemente Ximenis A,Crespí Bestard C,Cambra Conejero A,Pallarés Ferreres L,Juan Mas A,Olea Vallejo JL,Julià Benique MR

更新日期：2016-01-01 00:00:00

abstract：:Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...

journal_title：Human immunology

authors： Eckels DD,Woody JN,Hartzman RJ

更新日期：1981-10-01 00:00:00

abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...

journal_title：Human immunology

authors： Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard C

更新日期：2013-02-01 00:00:00

abstract：:Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associ...

journal_title：Human immunology

authors： Pan N,Chen K,Qiu J,Sun H,Xu J,Miao F,Shi Q,Jiang W,Jin H,He Y,Xie W,Zhang J

更新日期：2013-06-01 00:00:00

abstract：:There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...

journal_title：Human immunology

authors： Aultman D,Adamashvili I,Yaturu K,Langford M,Gelder F,Gautreaux M,Ghali GE,McDonald J

更新日期：1999-03-01 00:00:00

abstract：:Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...

journal_title：Human immunology

authors： Chávez-Sánchez L,Madrid-Miller A,Chávez-Rueda K,Legorreta-Haquet MV,Tesoro-Cruz E,Blanco-Favela F

更新日期：2010-08-01 00:00:00

abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...

journal_title：Human immunology

authors： Kishi H,Okumura A,Tong JJ,Sugiyama E,Matsuno H,Minowada J,Kanai T,Nishimura Y,Muraguchi A

更新日期：1997-08-01 00:00:00

abstract：:The expression pattern of several genes associated with different processes in melanocytes, including melanogenesis, is changed in vitiligo patients. We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), a...

journal_title：Human immunology

authors： Reimann E,Kingo K,Karelson M,Reemann P,Loite U,Sulakatko H,Keermann M,Raud K,Abram K,Vasar E,Silm H,Kõks S

更新日期：2012-04-01 00:00:00

abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...

journal_title：Human immunology

authors： Redpath S,Michaelsen TE,Sandlie I,Clark MR

更新日期：1998-11-01 00:00:00

abstract：:There are clinical situations in which it may be advantageous to monitor delayed type hypersensitivity (DTH) responses, an index of cell-mediated immunity, without exposing patients directly to the challenge antigens. For example, transplant patients may be at risk for becoming sensitized to donor antigens if injected...

journal_title：Human immunology

authors： Carrodeguas L,Orosz CG,Waldman WJ,Sedmak DD,Adams PW,VanBuskirk AM

更新日期：1999-08-01 00:00:00

abstract：:Natural killer (NK) cells are key members of innate immunity against tumor and infection. Killer cell immunoglobulin-like receptor (KIR) genes regulates NK cell function, which varies substantially between individuals in the number and type. Specific KIRs are associated with certain diseases. Herein we investigated if...

journal_title：Human immunology

authors： Ashouri E,Dabbaghmanesh MH,Rowhanirad S,Bakhshayeshkaram M,Ranjbar Omrani G,Ghaderi A

更新日期：2012-10-01 00:00:00

abstract：:Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant re...

journal_title：Human immunology

authors： Holder AL,Wolf S,Walshe C,Pandya P,Stanford RE,Smith JD,Rose ML,Lawson C

更新日期：2008-02-01 00:00:00

abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...

journal_title：Human immunology

authors： Zeevi A,Annen K,Scheffel C,Duquesnoy RJ

更新日期：1983-02-01 00:00:00

abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...

journal_title：Human immunology

authors： Han M,Fallena M,Guo Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：:The clonal selection theory of immune reactivity is based on a metaphor of self/not-self discrimination and considers self-tolerance to result from clonal deletion. There is evidence that a deletional mechanism is responsible for negative selection of self MHC-reactive T-cells in the thymus. Bretscher/Cohn theory buil...

journal_title：Human immunology

authors： Lafferty KJ,Gazda LS

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...

journal_title：Human immunology

authors： da Costa Lima Caniatti MC,Borelli SD,Guilherme AL,Tsuneto LT

更新日期：2017-02-01 00:00:00

abstract：:The Ia-like antigens of hybrids of the B-lymphoblastoid cell line (B-LCL) WI-L2 and a subline of the T-lymphoblastoid cell line (T-LCL) HSB were examined. Antigens of the HLA-DR and MT series were analyzed by indirect immunofluorescence with chimpanzee anti-DR sera and monoclonal antibodies, and antigens of the SB ser...

journal_title：Human immunology

authors： Howell DN,Hartzman RJ,Cresswell P

更新日期：1983-10-01 00:00:00

abstract：:A new treatment approach, involving intense immunosuppression and autologous hematopoietic stem cell transplantation (SCT), has emerged in recent years for the treatment of severe, refractory rheumatic autoimmune diseases including rheumatoid arthritis (RA). The rationale of this strategy is based on the concept of im...

journal_title：Human immunology

authors： Verburg Ro,Toes RE,Fibbe WE,Breedveld FC,van Laar JM

更新日期：2002-08-01 00:00:00

abstract：:Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...

journal_title：Human immunology

authors： Petermann I,Huebner C,Browning BL,Gearry RB,Barclay ML,Kennedy M,Roberts R,Shelling AN,Philpott M,Han DY,Ferguson LR

更新日期：2009-06-01 00:00:00

abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

journal_title：Human immunology

authors： Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

更新日期：2007-11-01 00:00:00

abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

journal_title：Human immunology

authors： Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

更新日期：1987-12-01 00:00:00

abstract：:The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were ...

journal_title：Human immunology

authors： Catamo E,Zupin L,Segat L,Celsi F,Crovella S

更新日期：2015-01-01 00:00:00

abstract：:Prevention of rejection and the induction of transplantation tolerance are two related but separable phenomena that must both be considered in the analysis of the response to a transplanted organ. It is frequently hard to separate these phenomena in assessing the outcome of clinical transplants, because patients are r...

journal_title：Human immunology

authors： Gianello PR,Sachs DH

更新日期：1996-09-15 00:00:00

abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...

journal_title：Human immunology

authors： Idris ZM,Miswan N,Muhi J,Mohd TA,Kun JF,Noordin R

更新日期：2011-07-01 00:00:00

abstract：:A comparison has been made of two methods for studying the immune response of human lymphocytes to antigens not experienced in vivo. In the first method, the sensitization-restimulation assay (or S/R test), lymphocytes from blood were sensitized to antigen in bulk cultures and then redistributed into microtiter plates...

journal_title：Human immunology

authors： Hensen EJ,Elferink D

更新日期：1984-06-01 00:00:00

abstract：:The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...

journal_title：Human immunology

authors： Sebti Y,Le Friec G,Pangault C,Gros F,Drénou B,Guilloux V,Bernard M,Lamy T,Fauchet R,Amiot L

更新日期：2003-11-01 00:00:00