Abstract:
:The clonal selection theory of immune reactivity is based on a metaphor of self/not-self discrimination and considers self-tolerance to result from clonal deletion. There is evidence that a deletional mechanism is responsible for negative selection of self MHC-reactive T-cells in the thymus. Bretscher/Cohn theory builds on this concept and provides a model which allows self/not-self discrimination to occur at any time throughout the life of the individual. However, modern concepts of antigen presentation in which MHC-peptide co-presentation is the unit recognised by the T-cell receptor have abandoned the Bretscher/Cohn requirement for associative recognition of antigen. For this reason, such models of APC function cannot use Bretscher/Cohn theory to explain self/not-self discrimination. Matzinger's 'danger' metaphor for the immune system provides a theoretical way forward by moving the emphasis away from an immune system based on self/not-self discrimination. These theoretical developments lead to a novel approach to the control of autoimmunity that is based on the strengthening of immune regulation by the use of adjuvant therapy.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Lafferty KJ,Gazda LSdoi
10.1016/S0198-8859(96)00294-7subject
Has Abstractpub_date
1997-02-01 00:00:00pages
119-26issue
2eissn
0198-8859issn
1879-1166pii
S0198-8859(96)00294-7journal_volume
52pub_type
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