Abstract：
:Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)), agonist steroid potency (EC(50)), and the percentage of full agonist activity for antisteroids (percent partial agonist activity). However, no reports exist for endogenous genes in primary human cells. Here we document that reduced concentrations of TIF2, a p160 coactivator, in peripheral blood mononuclear cells modulate these parameters for endogenous genes in a gene-selective manner, thus establishing the physiological relevance of this behavior.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Luo M,Simons SS Jrdoi
10.1016/j.humimm.2009.07.029subject
Has Abstractpub_date
2009-10-01 00:00:00pages
785-9issue
10eissn
0198-8859issn
1879-1166pii
S0198-8859(09)00204-3journal_volume
70pub_type
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