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Immunodeficiency diseases and expression of HLA antigens.

Abstract：

:The role of HLA antigens in lymphocyte differentiation is strongly suggested by the existence of a recently identified immunodeficiency associated with, and probably resulting from, the lack of expression of HLA-A, B, and C antigens as well as beta2 microglobulin on various cells of hematopoietic origin. This "bare lymphocyte syndrome" has been described in a family where the transmission appeared to be autosomal recessive, and the responsible gene was not borne by the sixth chromosome. Another infant with a severe combined immunodeficiency disease has been treated with fetal liver and thymus transplants (FLTT). A persisting chimerism has been documented: T cells derived from the donor and B cells from the host. Despite complete HLA-A, B, and DR mismatch, T and B cells did cooperate resulting in significant antibody production, and defense against viral infection has been normal. Such an observation may suggest that "allogeneic restriction" of T-cell effector functions can be circumvented.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Touraine JL,Bétuel H

doi

10.1016/0198-8859(81)90061-6

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

147-53

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(81)90061-6

journal_volume

2

pub_type

杂志文章

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