当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.

Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.

Abstract：

:The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination. Patients were classified by their METAVIR score as F1 (n = 100), F2 (n = 83), F3 (n = 101) or F4 (n = 66); 106 patients were diagnosed with HCC. Patients carrying the G/G genotype of C7 had a lower chance of developing severe fibrosis in the recessive model (p = 0.042; OR: 0.65 95% CI 0.41-1.02). However, the G/G genotype frequency was higher in patients with HCC (P = 0.01; OR: 2.07 95% CI 1.20-3.53) and in those with larger tumors (p = 0.04). The G/G C7 genotype seems to be a protective factor against advanced fibrosis; however, it was associated with a higher risk of HCC and the occurrence of larger hepatic nodules, suggesting the involvement of C7 in the physiopathogenesis of HCC and fibrosis in patients with hepatitis C virus (HCV).

journal_name

Hum Immunol

journal_title

Human immunology

authors

de Lima RE,de Holanda Martins CM,do Carmo RF,Aroucha DCBL,Pereira LMMB,Vasconcelos LRS,Moura P

doi

10.1016/j.humimm.2018.06.009

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

702-707

issue

9

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(18)30229-5

journal_volume

79

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients.

    abstract：:Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients an...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.12.019

    authors： Wang S,Delgado JC,Ravkov E,Eckels DD,Georgelas A,Pavlov IY,Cusick M,Sebastian K,Gleich GJ,Wagner LA

    更新日期：2012-04-01 00:00:00

  • Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

    abstract：:NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.02.018

    authors： Antoun A,Jobson S,Cook M,O'Callaghan CA,Moss P,Briggs DC

    更新日期：2010-06-01 00:00:00

  • Analysis of the cord blood T lymphocyte response to superantigen.

    abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00107-4

    authors： Macardle PJ,Wheatland L,Zola H

    更新日期：1999-02-01 00:00:00

  • Association of TNF -1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil.

    abstract：:Polymorphisms present in the TNF promoter region has shown to influence the gene transcription. Leprosy displays different clinical manifestations according to the immune responses of the individual infected with Mycobacterium leprae. In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs3...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2015.01.011

    authors： Silva GA,Ramasawmy R,Boechat AL,Morais AC,Carvalho BK,Sousa KB,Souza VC,Cunha MG,Barletta-Naveca RH,Santos MP,Naveca FG

    更新日期：2015-03-01 00:00:00

  • Full-length next-generation sequencing of HLA class I and II genes in a cohort from Thailand.

    abstract：:The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association ana...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.09.005

    authors： Geretz A,Ehrenberg PK,Bouckenooghe A,Fernández Viña MA,Michael NL,Chansinghakule D,Limkittikul K,Thomas R

    更新日期：2018-11-01 00:00:00

  • HLA and complement factors alleles sharing in Italian couples with recurrent spontaneous abortions.

    abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00028-7

    authors： Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

    更新日期：1998-06-01 00:00:00

  • Natural killer cell mediated cytotoxicity of tumor cells initiated by neem leaf preparation is associated with CD40-CD40L-mediated endogenous production of interleukin-12.

    abstract：:Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.08.002

    authors： Bose A,Baral R

    更新日期：2007-10-01 00:00:00

  • [C4d]FlowPRA screening--a specific assay for selective detection of complement-activating anti-HLA alloantibodies.

    abstract：:On waiting lists, transplant candidates are routinely screened for potentially harmful complement-fixing alloantibodies using complement-dependent cytotoxicity (CDC) panel-reactive antibody (PRA) testing. We have recently developed a novel cell-independent assay for assessment of complement-activating panel reactivity...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.12.007

    authors： Wahrmann M,Exner M,Haidbauer B,Schillinger M,Regele H,Körmöczi G,Böhmig GA

    更新日期：2005-05-01 00:00:00

  • Microsatellite mapping of a susceptible locus within the HLA region for Behçet's disease using Jordanian patients.

    abstract：:Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00246-9

    authors： Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

    更新日期：2001-02-01 00:00:00

  • Molecular complexity of HLA-DQw3: the TA10 determinant is located on a subset of DQw3 beta chains.

    abstract：:In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90076-0

    authors： Radka SF,Scott RG,Stewart SJ

    更新日期：1987-04-01 00:00:00

  • The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation.

    abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2008.07.014

    authors： Zozulya AL,Wiendl H

    更新日期：2008-11-01 00:00:00

  • Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City.

    abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtai...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.07.297

    authors： Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Bravo-Acevedo A,Juárez-Nicolás F,Arriaga-Perea AJ,Vega-Martínez MDR,Ortega-Yáñez A,Benítez-Arvizu G,Arrieta-Bolaños E,Clayton S,Juárez-Cortés ED,López-Gil C,García-Álvarez R

    更新日期：2020-09-01 00:00:00

  • Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes.

    abstract：:Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.09.005

    authors： Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

    更新日期：2004-12-01 00:00:00

  • TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.

    abstract：INTRODUCTION:Tyrosine kinase 2 gene (TYK2) is part of the janus kinase (JAK) that binds to the type I interferon-α receptor (IFNAR) on the cell surface of IFN-producing cells, and have crucial importance in the etiology of autoimmune and inflammatory diseases. Many polymorphisms of the TYK2 gene have been identified, a...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.09.007

    authors： Peluso C,Christofolini DM,Goldman CS,Mafra FA,Cavalcanti V,Barbosa CP,Bianco B

    更新日期：2013-01-01 00:00:00

  • Eotaxin-3 gene polymorphisms are associated with rheumatoid arthritis in a Korean population.

    abstract：:The eotaxin gene family (eotaxin, eotaxin-2, and eotaxin-3) has been implicated in the recruitment of eosinophils, basophiles and Th2 lymphocytes that is a central aspect of allergic diseases. We previously suggested that Eo2+179T>C and Eo2+275C>T of the eotaxin-2, and Eo3+2497T>G of the eotaxin-3 were significantly a...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2005.01.002

    authors： Chae SC,Park YR,Shim SC,Lee IK,Chung HT

    更新日期：2005-03-01 00:00:00

  • Inverse association of peripheral blood CD4(+) invariant natural killer T cells with atopy in human asthma.

    abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.10.011

    authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

    更新日期：2010-02-01 00:00:00

  • T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients.

    abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.05.008

    authors： Ma X,Zha J,He J,Chen L,Huang J,Wu W,Tian P,Qian BH,Yu L,Jiang Y,Xu B

    更新日期：2020-08-01 00:00:00

  • Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry.

    abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.06.025

    authors： Gragert L,Madbouly A,Freeman J,Maiers M

    更新日期：2013-10-01 00:00:00

  • Rapid evaluation of soluble HLA-G levels in supernatants of in vitro fertilized embryos.

    abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.11.003

    authors： Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

    更新日期：2007-04-01 00:00:00

  • HLA gene haplotype frequencies in bone marrow donors worldwide registries.

    abstract：:To calculate reliable HLA gene and haplotype frequencies of bone marrow donors in various regions in the world, we have analyzed the HLA-A, -B, and -DR phenotype frequencies of 18 bone marrow donor registries with a total of more than 300,000 HLA-A, -B-typed donors. These registries were included in the 22nd edition o...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(96)00257-1

    authors： Schipper RF,D'Amaro J,Bakker JT,Bakker J,van Rood JJ,Oudshoorn M

    更新日期：1997-01-01 00:00:00

  • Four tumor necrosis factor alpha genes polymorphisms and periodontitis risk in a Chinese population.

    abstract：BACKGROUND:Tumour necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of generalized aggressive periodontitis (AgP) and chronic periodontitis (CP). The objective of the present study was to evaluate the association of four TNF-alpha gene polymorphisms (-1031T/C, -857C/T, -308G/A and -238G/A) with ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.009

    authors： Yang W,Jia Y,Wu H

    更新日期：2013-12-01 00:00:00

  • Association between human leukocyte antigen class I and II alleles and hepatitis C virus infection in high-risk hemodialysis patients awaiting kidney transplantation.

    abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.008

    authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

    更新日期：2013-12-01 00:00:00

  • Molecular cloning and characterization of cynomolgus monkey Fas.

    abstract：:The Fas-FasL system plays a crucial role in the maintenance of homeostasis in the immune system. To characterize the Fas/FasL system in macaque monkeys that are commonly used as experimental primates, we cloned and sequenced Fas cDNA derived from the cynomolgus monkey. The predicted amino acid sequence consists of 331...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00100-2

    authors： Murayama Y,Terao K,Inoue-Murayama M

    更新日期：2000-05-01 00:00:00

  • Variable clinical phenotypes of X-linked lymphoproliferative syndrome in China: Report of five cases with three novel mutations and review of the literature.

    abstract：BACKGROUND:X-linked lymphoproliferative disease (XLP) is a rare life-threatening syndrome. Rapid recognition and definitive diagnosis are critical to improve the prognosis and survival of patients with XLP. Nowadays, little is known about patients with XLP in China. METHODS:We report the characterization of five Chine...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2016.06.005

    authors： Jin YY,Zhou W,Tian ZQ,Chen TX

    更新日期：2016-08-01 00:00:00

  • The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysis.

    abstract：:This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90115-6

    authors： Lee KW,Hurley CK,Hartzman R,Johnson AH

    更新日期：1990-11-01 00:00:00

  • Allele polymorphism and haplotype diversity of MICA/B in Tujia nationality of Zhangjiajie, Hunan Province, China.

    abstract：:Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.03.005

    authors： Wang YJ,Zhang NJ,Chen E,Chen CJ,Bu YH,Yu P

    更新日期：2016-05-01 00:00:00

  • Sequential analysis by immunoprecipitation-MALDI-TOF: a novel method for detection and identification of alloantibody specificities.

    abstract：:Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.02.006

    authors： Heinold A,Kuehl B,Brenner-Weiss G,Opelz G,Tran TH

    更新日期：2010-05-01 00:00:00

  • Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus.

    abstract：:Genes encoding for prolactin (PRL) and its receptor (PRLR) are possible candidates for multiple sclerosis (MS) and systemic lupus erythematosus (SLE) susceptibility. In fact: (1) a prolactin secretion dysfunction has been described in several autoimmune diseases including SLE and MS and their animal models; (2) both P...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00804-2

    authors： Mellai M,Giordano M,D'Alfonso S,Marchini M,Scorza R,Danieli M.G.,Leone M,Ferro I,Liguori M,Trojano M,Ballerini C,Massacesi L,Cannoni S,Bomprezzi R,Momigliano-Richiardi P

    更新日期：2003-02-01 00:00:00

  • Genetic mapping of the hemochromatosis locus on chromosome six.

    abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90005-1

    authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

    更新日期：1980-07-01 00:00:00

  • EBV transformed B cell lines present to antigen specific T cell clones determinants different from those recognized by antibody in an HLA-DR linked restricted fashion.

    abstract：:Human B cells nonspecifically activated by Epstein Barr virus (EBV) can present tetanus toxoid (TT) antigen to TT specific helper T cell lines and T cell clones. Presentation of TT antigen by EBV-B cells did not require the presence of TT specific B cells and did not involve B cell surface immunoglobulins. Immunosorbe...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(83)90039-3

    authors： Chu E,Umetsu D,Yunis E,Geha RS

    更新日期：1983-11-01 00:00:00