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CD8+ regulatory T cells in persistent human viral infections.

Abstract：

:Regulatory T cells (T(reg) cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), and herpes virus. It has recently become evident that immune regulation mediated by T(reg) cells may comprise one mechanism that contributes to the impairment of virus-specific immune responses. Indeed, during viral infection, the generation of distinct subsets of CD4+ as well as CD8+ T(reg) cells has been reported. The phenotypic and functional heterogeneity of T(reg) cell subsets involved in the suppression of virus-specific immune responses suggests that different mechanisms and factors contribute to the generation of those cells during viral infection. This review focuses on the CD8+ T(reg) cell subset and summarizes current knowledge about the induction and function of CD8+ T(reg) cells in persistent human virus infections.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Billerbeck E,Thimme R

doi

10.1016/j.humimm.2008.07.016

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

771-5

issue

11

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(08)00148-1

journal_volume

69

pub_type

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