CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis.

abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...

journal_title：Human immunology

authors： Dave VP,Larché M,Rencher SD,Koop BF,Hurwitz JL

更新日期：1993-07-01 00:00:00

abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...

journal_title：Human immunology

authors： Raaphorst FM,Schelonka RL,Rusnak J,Infante AJ,Teale JM

更新日期：2002-01-01 00:00:00

abstract：:Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...

journal_title：Human immunology

authors： Gedde-Dahl T 3rd,Eriksen JA,Thorsby E,Gaudernack G

更新日期：1992-04-01 00:00:00

abstract：:This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...

journal_title：Human immunology

authors： Lindemann M,Dioury Y,Beckebaum S,Cicinnati VR,Gerken G,Broelsch CE,Wrighton-Smith P,Grosse-Wilde H

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the role of LMP (low molecular weight protein) genes as susceptibility markers for spondyloarthritis (SpA), LMP gene polymorphisms were analyzed in 223 Mexican patients with SpA (81 undifferentiated SpA [U-SpA], 117 with ankylosing spondylitis [AS], 25 with reactive arthritis) and in 139 ethnically matched...

journal_title：Human immunology

authors： Vargas-Alarcón G,Gamboa R,Zuñiga J,Fragoso JM,Hernández-Pacheco G,Londoño J,Pacheco-Tena C,Cardiel MH,Granados J,Burgos-Vargas R

更新日期：2004-12-01 00:00:00

abstract：:We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...

journal_title：Human immunology

authors： Mion M,Indraccolo S,Feroli F,Minuzzo S,Masiero S,Zamarchi R,Barelli A,Borri A,Chieco-Bianchi L,Amadori A

更新日期：1997-10-01 00:00:00

abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

journal_title：Human immunology

authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

更新日期：2003-05-01 00:00:00

abstract：:Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...

journal_title：Human immunology

authors： Bennet AM,Alarcón-Riquelme M,Wiman B,de Faire U,Prokunina-Olsson L

更新日期：2006-09-01 00:00:00

abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

journal_title：Human immunology

authors： Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

更新日期：2004-04-01 00:00:00

abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...

journal_title：Human immunology

authors： Zachary AA,Bias WB,Johnson A,Rose SM,Leffell MS

更新日期：2001-10-01 00:00:00

abstract：:Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...

journal_title：Human immunology

authors： van Kampen CA,Versteeg-vd Voort Maarschalk MF,Langerak-Langerak J,Roelen DL,Claas FH

更新日期：2002-06-01 00:00:00

abstract：:Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...

journal_title：Human immunology

authors： Mizuki N,Yabuki K,Ota M,Verity D,Katsuyama Y,Ando H,Onari K,Goto K,Imagawa Y,Mandanat W,Fayyad F,Stanford M,Ohno S,Inoko H

更新日期：2001-02-01 00:00:00

abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...

journal_title：Human immunology

authors： Zeevi A,Annen K,Scheffel C,Duquesnoy RJ

更新日期：1983-02-01 00:00:00

abstract：:Several investigators have reported that subdivisions of HLA-B44, which are not defined by available cytotoxic antisera, can be detected by cytotoxic T lymphocytes. The present study was designed to evaluate two sera which appear to recognize a specificity on some HLA-B44 and B45 positive cells and to determine whethe...

journal_title：Human immunology

authors： Heise ER,Tekolf WA,Hampton JP

更新日期：1984-11-01 00:00:00

abstract：:Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...

journal_title：Human immunology

authors： Oliveira LM,Portela P,Merzoni J,Lindenau JD,Dias FS,Beppler J,Graebin P,Alho CS,Schwartsmann G,Dal-Pizzol F,Jobim LF,Jobim M,Roesler R

更新日期：2017-04-01 00:00:00

abstract：:Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...

journal_title：Human immunology

authors： Eckels DD,Woody JN,Hartzman RJ

更新日期：1981-10-01 00:00:00

abstract：:Class I molecules of the major histocompatibility complex bind peptides derived from cytosolic proteins and display them on the cell surface. This function alerts cytotoxic T cells to the presence of intracellular pathogens. Class I molecule assembly requires the association of the heavy chain with beta 2-microglobuli...

journal_title：Human immunology

authors： Bresnahan PA,Barber LD,Brodsky FM

更新日期：1997-04-01 00:00:00

abstract：:While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...

journal_title：Human immunology

authors： Schöfl G,Schmidt AH,Lange V

更新日期：2016-03-01 00:00:00

abstract：:The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...

journal_title：Human immunology

authors： Fainboim L,Marcos Y,Pando M,Capucchio M,Reyes GB,Galoppo C,Badía I,Remondino G,Ciocca M,Ramonet M

更新日期：1994-10-01 00:00:00

abstract：:Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. Hereditary etiology has been proposed as a cause of the sarcoidosis, and some Human Leucocyte Antigen (HLA) alleles have been related to the diagnosis or severity of the disease. Löfgren's syndrome has been linked to patients with the DRB1*03 all...

journal_title：Human immunology

authors： da Costa CH,Silva VL,Fabricio-Silva GM,Usnayo M,Rufino R,Porto LC

更新日期：2013-10-01 00:00:00

abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

journal_title：Human immunology

authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

更新日期：1989-09-01 00:00:00

abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...

journal_title：Human immunology

authors： Ishikawa Y,Tokunaga K,Lin L,Imanishi T,Saitou S,Kimura A,Kashiwase K,Akaza T,Tadokoro K,Juji T

更新日期：1994-03-01 00:00:00

abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

journal_title：Human immunology

authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

更新日期：1996-06-01 00:00:00

abstract：:The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...

journal_title：Human immunology

authors： O'Neill GJ,Miniter P,Pollack MS,Dupont B

更新日期：1980-07-01 00:00:00

abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...

journal_title：Human immunology

authors： Torres MI,Luque J,Lorite P,Isla-Tejera B,Palomeque T,Aumente MD,Arizon J,Peña J

更新日期：2009-10-01 00:00:00

abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

journal_title：Human immunology

authors： Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

更新日期：2007-11-01 00:00:00

abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

journal_title：Human immunology

authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

更新日期：1990-02-01 00:00:00

abstract：:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

journal_title：Human immunology

authors： Poláková K,Kuba D,Russ G

更新日期：2004-02-01 00:00:00

abstract：:This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom ...

journal_title：Human immunology

authors： Dettogni RS,Tristão-Sá R,Dos Santos M,da Silva FF,Louro ID

更新日期：2015-10-01 00:00:00

abstract：:The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-ant...

journal_title：Human immunology

authors： Hachem RR

更新日期：2019-08-01 00:00:00