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Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons.

Abstract：

:This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom persistence. During 2012-2013, 96 blood samples from individuals diagnosed with symptomatic dengue were collected. Clinical symptom persistence in 60days of follow-up was assessed by a clinical and epidemiological questionnaire filled in 4 interviews. SNP genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In two months of monitoring the dengue infection, we observed that symptoms persisted in 38.5% (37/96) of dengue patients at the end of the first month (D30) and in 11.5% (11/96) of dengue patients at the end of the second month (D60). Our results show an association between FcγRIIa, TNF-α and IL-6 gene SNPs and symptom persistence and an association trend with CD209, IL-4 and IFN-γ gene SNPs. Our findings may increase the knowledge on the pathophysiological mechanisms of persistent symptoms of infection with the dengue virus (DENV) and thus help the clinical management of patients.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Dettogni RS,Tristão-Sá R,Dos Santos M,da Silva FF,Louro ID

doi

10.1016/j.humimm.2015.09.026

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

717-23

issue

10

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(15)00463-2

journal_volume

76

pub_type

杂志文章

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