Abstract：
:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The objective of this study was to further define the effect of IFN-alpha/ribavirin therapy on type 1 and type 2 HCV-specific CD4(+) and CD8(+) T-cell responses during IFN-alpha/ribavirin therapy. Toward this, serial CD8(+) T-cell responses to HCV-derived epitopes and CD4(+) T-cell responses to the HCV core antigen were analyzed in four patients before (baseline), during (at 24 weeks), and at the end (at 48 weeks) of IFN-alpha/ribavirin therapy. Therapy-induced viral clearance in three patients was associated with a significant augmentation of HCV-specific type 1 CD4(+) and CD8(+) T-cell responses. In contrast, in a patient who did not respond to therapy, a significant HCV-specific CD4(+) Th2 cell reactivity was observed accompanied by a lack of augmentation of the HCV-specific CD8(+) T-cell reactivity. These results indicate that enhancement of HCV-specific CD4(+) and CD8(+) T-cell responses is an important factor in determining the response to the IFN-alpha/ribavirin therapy and the outcome of the HCV infection.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar Tdoi
10.1016/s0198-8859(03)00041-7subject
Has Abstractpub_date
2003-05-01 00:00:00pages
497-504issue
5eissn
0198-8859issn
1879-1166pii
S0198885903000417journal_volume
64pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:Using a large battery of Bw16, w38, and w39 antisera, a new variant of Bw16 has been identified in four unrelated Mexican-American families. The serologic pattern obtained is distinct from that for Bw38, Bw39, and 8W57 antigens. Absorption studies confirm the existence of this new Bw16 subtype which we term ST-16. ST-...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(82)90050-7
更新日期：1982-02-01 00:00:00
abstract：:CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cel...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90011-d
更新日期：1990-06-01 00:00:00
abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00053-6
更新日期：1998-08-01 00:00:00
abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.03.017
更新日期：2011-07-01 00:00:00
abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.05.008
更新日期：2020-08-01 00:00:00
abstract：:Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellu...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.03.008
更新日期：2017-01-01 00:00:00
abstract：:Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.05.005
更新日期：2006-09-01 00:00:00
abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90046-3
更新日期：1989-01-01 00:00:00
abstract：:The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2004.04.005
更新日期：2004-07-01 00:00:00
abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：:Better outcome for hematopoietic stem cell transplantation (HSCT) requires optimal matching between donor and recipient at the HLA-A, -B, -C, and -DRB1 loci. This study estimates the likelihood of identifying HLA matched donors in Hong Kong. 7595 volunteer unrelated Chinese donors at the Hong Kong Bone Marrow Donor Re...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.08.007
更新日期：2017-10-01 00:00:00
abstract：:Nijmegen breakage syndrome (NBS) is a rare chromosomal-instability syndrome associated with defective DNA repair. Approximately 90% of NBS patients are homozygous for a truncating mutation of the NBS1 gene. As development of the immune system relies on recombination, which involves repair of DNA breaks, one might pred...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00345-7
更新日期：2001-12-01 00:00:00
abstract：:Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(81)90050-1
更新日期：1981-10-01 00:00:00
abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(83)90066-6
更新日期：1983-02-01 00:00:00
abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(83)80011-1
更新日期：1983-06-01 00:00:00
abstract：:Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.04.024
更新日期：2013-08-01 00:00:00
abstract：:CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic difference...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.05.005
更新日期：2020-07-01 00:00:00
abstract：:The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(02)00755-3
更新日期：2002-12-01 00:00:00
abstract：:The HER-2/neu protein is overexpressed in approximately 20% of human adenocarcinomas and is a defined tumor antigen in breast cancer. The purpose of this study was to evaluate the endogenous HER-2/neu specific antibody response in 57 patients with colorectal cancer. HER-2/neu specific antibodies, titer > or = 1:100, w...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00003-8
更新日期：1999-06-01 00:00:00
abstract：:The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90078-5
更新日期：1989-07-01 00:00:00
abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.08.297
更新日期：2006-11-01 00:00:00
abstract：:Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.10.003
更新日期：2008-12-01 00:00:00
abstract：:Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.07.023
更新日期：2009-12-01 00:00:00
abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(97)00143-2
更新日期：1997-08-01 00:00:00
abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(99)00151-2
更新日期：2000-02-01 00:00:00
abstract：:Cytomegalovirus (CMV) is a well-known cause of disease occurring after bone marrow transplantation (BMT). The manifestations of CMV range from asymptomatic infection, defined as active CMV replication in the blood in the absence of clinical manifestations or organ failure abnormalities, to CMV disease, characterized b...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2004.02.013
更新日期：2004-05-01 00:00:00
abstract：:We have investigated if recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), alone or in concert with recombinant gamma interferon, affects the endothelial cell expression of class I major histocompatibility complex antigen. Results obtained show that the GM-CSF increases class I expression on the en...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90016-i
更新日期：1990-06-01 00:00:00
abstract：:There is increased evidence about the deleterious effect of delayed graft function (DGF) in both short- and long-term kidney graft outcome. Among the mechanisms involved in the production of DGF, immune factors play a role, especially in the level of hypersensitization. From the 1389 patients transplanted at our hospi...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2005.01.026
更新日期：2005-04-01 00:00:00
abstract：:Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the major histocompatibility complex. HLA-G appears to play a role in the suppression of immune responses and contribute to long-term immune escape or tolerance. The focus of this review is polymorphism in the HLA-G gene and protein and...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2009.07.015
更新日期：2009-12-01 00:00:00
abstract：:While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.01.012
更新日期：2016-03-01 00:00:00
