Abstract：
:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones HJ1, HJ39, and HJ37. Five different anti-DR Mab had no significant inhibitory effect on these clones. On the other hand, two Mab SG171 and Q5/13 which appear to react with DR and MT3 (I-A like) molecules strongly inhibited the two MT3-specific PLT clones. While SG171 and Q5/13 had little effect on HJ37, it was observed that a polymorphic Mab 17.15 had a strong inhibitory effect. These results, in concordance with biochemical data on Ia molecules precipitated by these Mab, suggest that these alloreactive clones may recognize non-DR PLT determinants. They also provide further indirect support that MT3 molecules represent the human homologue of murine I-A molecules.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Zeevi A,Annen K,Scheffel C,Duquesnoy RJdoi
10.1016/0198-8859(83)90066-6subject
Has Abstractpub_date
1983-02-01 00:00:00pages
97-109issue
2eissn
0198-8859issn
1879-1166pii
0198-8859(83)90066-6journal_volume
6pub_type
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