The impact of non-HLA antibodies on outcomes after lung transplantation and implications for therapeutic approaches.

abstract：:"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...

journal_title：Human immunology

authors： Stegall MD,Stock PG,Andreoni K,Friedewald JJ,Leichtman AB

更新日期：2017-01-01 00:00:00

abstract：:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

journal_title：Human immunology

authors： Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

更新日期：1989-11-01 00:00:00

abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...

journal_title：Human immunology

authors： Zachary AA,Bias WB,Johnson A,Rose SM,Leffell MS

更新日期：2001-10-01 00:00:00

abstract：:This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom ...

journal_title：Human immunology

authors： Dettogni RS,Tristão-Sá R,Dos Santos M,da Silva FF,Louro ID

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...

journal_title：Human immunology

authors： Shehjar F,Afroze D,Misgar RA,Malik SA,Laway BA

更新日期：2018-04-01 00:00:00

abstract：:This article hashas been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Human immunology

authors： Li T,Huang H,Liao D,Ling H,Su B,Cai M

更新日期：2015-11-14 00:00:00

abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

journal_title：Human immunology

authors： Macardle PJ,Wheatland L,Zola H

更新日期：1999-02-01 00:00:00

abstract：:In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being...

journal_title：Human immunology

authors： Kriener K,O'hUigin C,Klein J

更新日期：2001-01-01 00:00:00

abstract：:Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...

journal_title：Human immunology

authors： García-Obregón S,Alfonso-Sánchez MA,Pérez-Miranda AM,Gómez-Pérez L,de Parcorbo MM,Peña JA

更新日期：2012-07-01 00:00:00

abstract：:NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...

journal_title：Human immunology

authors： Antoun A,Jobson S,Cook M,O'Callaghan CA,Moss P,Briggs DC

更新日期：2010-06-01 00:00:00

abstract：:The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The lev...

journal_title：Human immunology

authors： Coon JS,Wang YZ,Bines SD,Markham PN,Chong AS,Gebel HM

更新日期：1991-10-01 00:00:00

abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...

journal_title：Human immunology

authors： Knutson KL,Disis ML

更新日期：2002-07-01 00:00:00

abstract：:Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promote...

journal_title：Human immunology

authors： Faik I,Oyedeji SI,Idris Z,de Messias-Reason IJ,Lell B,Kremsner PG,Kun JF

更新日期：2011-01-01 00:00:00

abstract：:A PCR-based SSO-assay has been developed to characterize the allelic polymorphism at the HLA-DPA1 locus. To validate the performance of this assay, 77 samples were typed side by side in a blinded fashion by the SSO assay and sequencing-based typing (SBT); 100% concordance was seen between the two methods. To address q...

journal_title：Human immunology

authors： Moonsamy PV,Klitz W,Tilanus MG,Begovich AB

更新日期：1997-12-01 00:00:00

abstract：:The class II MHC gene DPA is inducible by interferon-gamma (IFN-gamma), whereas the DQB gene is not inducible in most cell types. To investigate the DNA region specifically responsible for inducibility or its lack that may be required (in addition to the elements required for constitutive expression of class II genes)...

journal_title：Human immunology

authors： Sugawara M,Ponath PD,Yang Z,Strominger JL

更新日期：1992-11-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...

journal_title：Human immunology

authors： Zhong X,Wu Y,Liu Y,Zhu F,Li X,Li D,Li Z,Zeng L,Qiao J,Chen X,Xu K

更新日期：2016-08-01 00:00:00

abstract：:It is generally accepted that dendritic cells can be generated from either myeloid or lymphoid derived progenitors. Ample information has been collected on the development and nature of myeloid DC type 1 (DC1). In contrast, our current understanding on the origin and function of the lymphoid derived DC type 2 (DC2) is...

journal_title：Human immunology

authors： Blom B,Ligthart SJ,Schotte R,Spits H

更新日期：2002-12-01 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a rare chromosomal-instability syndrome associated with defective DNA repair. Approximately 90% of NBS patients are homozygous for a truncating mutation of the NBS1 gene. As development of the immune system relies on recombination, which involves repair of DNA breaks, one might pred...

journal_title：Human immunology

authors： van Engelen BG,Hiel JA,Gabreëls FJ,van den Heuvel LP,van Gent DC,Weemaes CM

更新日期：2001-12-01 00:00:00

abstract：:Two hundred and three sera obtained from multiparous women were screened to determine the frequency of the appearance of antibodies reactive with PHA-activated T lymphocytes, but not with resting B or T cells from the same donor. The panel of cells on which the sera were tested consisted of lymphocytes from 38 unrelat...

journal_title：Human immunology

authors： Kim SJ,Christiansen FT,Gosar I,Silver DM,Pollack MS,Dupont B

更新日期：1980-12-01 00:00:00

abstract：:The T-helper 1 (Th1) immune reaction is most important in dendritic cell (DC)-based immunotherapy. Interleukin (IL)-18, a Th1-biasing cytokine, plays a pivotal role in inducing cytotoxic T lymphocyte (CTL) responses. In this study, we analyzed whether dendritic cells (DCs) from patients with hepatocellular carcinoma (...

journal_title：Human immunology

authors： Cao DY,Yang JY,Dou KF,Ma LY,Teng ZH

更新日期：2007-05-01 00:00:00

abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

journal_title：Human immunology

authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

更新日期：1980-07-01 00:00:00

abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...

journal_title：Human immunology

authors： De Maria A,Moretta L

更新日期：2000-01-01 00:00:00

abstract：:This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...

journal_title：Human immunology

authors： Lee KW,Hurley CK,Hartzman R,Johnson AH

更新日期：1990-11-01 00:00:00

abstract：:Cell-mediated cytotoxicity involves a localized secretory process in which lytic agents stored in specialized granules of the effector cells are released upon contact with the appropriate target cell membrane and cause membrane damage. The protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP) inhibits cytotoxici...

journal_title：Human immunology

authors： McKinnon KP,Dunlevy JR,Dawson JR,Argon Y

更新日期：1988-06-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...

journal_title：Human immunology

authors： Liu Y,Liang WB,Gao LB,Pan XM,Chen TY,Wang YY,Xue H,Zhang LS,Zhang L

更新日期：2010-11-01 00:00:00

abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

journal_title：Human immunology

authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

更新日期：2013-05-01 00:00:00

abstract：:Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1...

journal_title：Human immunology

authors： Frisullo G,Iorio R,Plantone D,Nociti V,Patanella AK,Marti A,Palermo C,Valentini P,Mariotti P,Batocchi AP

更新日期：2011-08-01 00:00:00

abstract：:The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...

journal_title：Human immunology

authors： Rasmussen HB,Kelly MA,Clausen J

更新日期：2001-04-01 00:00:00

abstract：:Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

journal_title：Human immunology

authors： Puri NK,de Kretser T,Brandon MR

更新日期：1987-11-01 00:00:00

abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

journal_title：Human immunology

authors： Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

更新日期：1989-05-01 00:00:00