Abstract:
:Two hundred and three sera obtained from multiparous women were screened to determine the frequency of the appearance of antibodies reactive with PHA-activated T lymphocytes, but not with resting B or T cells from the same donor. The panel of cells on which the sera were tested consisted of lymphocytes from 38 unrelated donors known to be homozygous at the HLA-D locus. Forty-two sera were shown to react uniquely with PHA-activated T cells. The reactivities of these sera could not be explained in terms of the defined HLA-A,-B,-C, or DR antigen specificities on the panel cells, nor on the basis of known cross-reactivities among these antigens. Most of the antisera showed strong cytotoxicity with the activated T cells. Such sera may define antigens presented to the maternal immune system during differentiation and development, which are not expressed on adult T cells unless they are activated.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Kim SJ,Christiansen FT,Gosar I,Silver DM,Pollack MS,Dupont Bdoi
10.1016/0198-8859(80)90110-xsubject
Has Abstractpub_date
1980-12-01 00:00:00pages
347-55issue
4eissn
0198-8859issn
1879-1166pii
0198-8859(80)90110-Xjournal_volume
1pub_type
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