Abstract：
:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, B7 and A28, B12 haplotypes. The hemochromatosis locus segregated with the HLA-A locus and not with the HLA-B locus. Thus, the hemochromatosis locus maps in close proximity to the HLA-A locus.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Edwards CQ,Cartwright GE,Skolnick MH,Amos DBdoi
10.1016/0198-8859(80)90005-1subject
Has Abstractpub_date
1980-07-01 00:00:00pages
19-22issue
1eissn
0198-8859issn
1879-1166pii
0198-8859(80)90005-1journal_volume
1pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:The class II MHC gene DPA is inducible by interferon-gamma (IFN-gamma), whereas the DQB gene is not inducible in most cell types. To investigate the DNA region specifically responsible for inducibility or its lack that may be required (in addition to the elements required for constitutive expression of class II genes)...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(92)90100-2
更新日期：1992-11-01 00:00:00
abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(91)90059-i
更新日期：1991-11-01 00:00:00
abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.10.007
更新日期：2006-12-01 00:00:00
abstract：:This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.07.018
更新日期：2008-11-01 00:00:00
abstract：:Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.04.003
更新日期：2005-07-01 00:00:00
abstract：:To evaluate the role of tumor necrosis factor-alpha (TNF-alpha) gene as susceptibility marker for spondyloarthritis (SpA), two polymorphisms (-238 and -308 positions) were analyzed in 229 patients with SpA (113 with ankylosing spondylitis [AS], 92 with undifferentiated SpA [U-SpA], 24 with reactive arthritis), and 169...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.07.009
更新日期：2006-10-01 00:00:00
abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.05.005
更新日期：2018-08-01 00:00:00
abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.03.010
更新日期：2007-07-01 00:00:00
abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.07.014
更新日期：2008-11-01 00:00:00
abstract：:Rat soluble MHC class I synthesis was studied at both RNA and protein levels to determine whether multiple forms of soluble MHC class I molecules are produced by different mechanisms. RT-PCR and sequencing of MHC class I transcripts identified an alternatively spliced nonclassical MHC class I gene product, lacking bot...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00039-1
更新日期：1998-07-01 00:00:00
abstract：:Cytomegalovirus (CMV) is a well-known cause of disease occurring after bone marrow transplantation (BMT). The manifestations of CMV range from asymptomatic infection, defined as active CMV replication in the blood in the absence of clinical manifestations or organ failure abnormalities, to CMV disease, characterized b...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2004.02.013
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS:We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS:Nineteen studies ...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2015.01.023
更新日期：2015-03-01 00:00:00
abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...
journal_title：Human immunology
pub_type： 多中心研究
doi：10.1016/s0198-8859(01)00305-6
更新日期：2001-10-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). METHODS:The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G ...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2014.02.020
更新日期：2014-05-01 00:00:00
abstract：:The modified mixed leukocyte reaction (MMLR) test consists of the standard MLR (SMLR) test to which interleukin-4 (IL-4) has been added. It is a sensitive procedure capable of detecting alloreactivity not detected by the SMLR. In the present study we applied the MMLR test to unrelated bone marrow transplantation (BMT)...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00065-8
更新日期：1999-09-01 00:00:00
abstract：:Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear. We conducted experiments to investigate whether β-1,4-GalT-I is participating in the activation of Jurkat T cell and intercellular conta...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2014.08.199
更新日期：2014-10-01 00:00:00
abstract：:The contributions of individual amino acids in the polymorphic beta chain and the conserved alpha chain of HLA-DR1 to influenza HA-specific DR1-restricted and anti-DR1 allospecific T-cell recognition were analyzed. The genes encoding HLA-DR1 were subjected to site-directed mutagenesis in order to introduce single amin...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90031-0
更新日期：1994-08-01 00:00:00
abstract：:In our earlier studies, single nucleotide polymorphisms (SNPs) associated with anti-inflammatory cytokines were found to influence risk for breast cancer in western Indian women. Analysis of Interleukin 6 (IL-6) -174G>C polymorphism in this cohort (patients = 182; controls = 236) suggested a protective role for IL-6 -...
journal_title：Human immunology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.humimm.2014.06.018
更新日期：2014-08-01 00:00:00
abstract：:Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.09.010
更新日期：2015-09-01 00:00:00
abstract：:T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(84)90060-0
更新日期：1984-12-01 00:00:00
abstract：OBJECTIVES:The tumour necrosis factor superfamily 4 (TNFSF4) is a candidate gene for autoimmune diseases. We investigated the relationship of this gene with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Chinese Guangxi population. METHODS:A total of 294 patients with SLE, 210 with RA, and 282 h...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.11.006
更新日期：2019-04-01 00:00:00
abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00152-g
更新日期：1995-07-01 00:00:00
abstract：:Better outcome for hematopoietic stem cell transplantation (HSCT) requires optimal matching between donor and recipient at the HLA-A, -B, -C, and -DRB1 loci. This study estimates the likelihood of identifying HLA matched donors in Hong Kong. 7595 volunteer unrelated Chinese donors at the Hong Kong Bone Marrow Donor Re...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.08.007
更新日期：2017-10-01 00:00:00
abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90263-1
更新日期：1994-03-01 00:00:00
abstract：:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.01.020
更新日期：2008-04-01 00:00:00
abstract：:CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic difference...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.05.005
更新日期：2020-07-01 00:00:00
abstract：:Human T suppressor cells (Ts), capable of preventing autologous T helper cells (Th) from reacting against xenogeneic pig endothelial cells and pig APC can be generated in vitro. Ts derive from a population of CD3(+)CD8(+)CD28(-) T lymphocytes and specifically recognize the MHC class I antigens of the APC used for in v...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00238-5
更新日期：2001-05-01 00:00:00
abstract：:Two hundred and three sera obtained from multiparous women were screened to determine the frequency of the appearance of antibodies reactive with PHA-activated T lymphocytes, but not with resting B or T cells from the same donor. The panel of cells on which the sera were tested consisted of lymphocytes from 38 unrelat...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(80)90110-x
更新日期：1980-12-01 00:00:00
abstract：:A number of anti-H-2 alloantisera containing antibody reactive with I region gene products (Ia) of the major histocompatibility complex cross-react with determinants expressed by human peripheral blood B lymphocytes. Such data have led to the conclusion that Ia and DR antigens share cross-reacting determinants. We hav...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(83)80011-1
更新日期：1983-06-01 00:00:00
abstract：:Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.02.005
更新日期：2019-07-01 00:00:00
