Overexpression of the PDCD2-like gene results in inhibited TNF-alpha production in activated Daudi cells.

Abstract:

:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 was downregulated. Overexpression of PDCD2-like gene effectively attenuated tumor necrosis factor (TNF)-alpha release but elevated interleukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS). It is possible that both proteins have anti-inflammatory effects like IL-6. The results have implications for understanding the function of PDCD2/PDCD2-like proteins and may help in the development of novel anti-inflammatory drugs.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JP

doi

10.1016/j.humimm.2008.01.020

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

259-65

issue

4-5

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(08)00009-8

journal_volume

69

pub_type

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