Abstract:
:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 was downregulated. Overexpression of PDCD2-like gene effectively attenuated tumor necrosis factor (TNF)-alpha release but elevated interleukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS). It is possible that both proteins have anti-inflammatory effects like IL-6. The results have implications for understanding the function of PDCD2/PDCD2-like proteins and may help in the development of novel anti-inflammatory drugs.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JPdoi
10.1016/j.humimm.2008.01.020subject
Has Abstractpub_date
2008-04-01 00:00:00pages
259-65issue
4-5eissn
0198-8859issn
1879-1166pii
S0198-8859(08)00009-8journal_volume
69pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.10.003
更新日期:2008-12-01 00:00:00
abstract::In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90017-5
更新日期:1985-06-01 00:00:00
abstract::Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.09.009
更新日期:2011-01-01 00:00:00
abstract::This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90022-9
更新日期:1985-05-01 00:00:00
abstract::The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(80)90005-1
更新日期:1980-07-01 00:00:00
abstract:PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.02.006
更新日期:2018-04-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultured endothelial cells and cocultured ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(95)00095-x
更新日期:1995-11-01 00:00:00
abstract::In an attempt to develop a suitable model for increasing the yield of human anti-HLA mAbs, we have used mice with SCID for i.p. injection of two human-mouse heterohybridomas. HMP1 hybridoma secretes a DQB1*0201 allele-specific human mAb whereas HMP12 secretes a human mAb recognizing the DRB1*1101, 1102, 1103, and 1104...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90008-b
更新日期:1992-12-01 00:00:00
abstract::Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.03.002
更新日期:2009-06-01 00:00:00
abstract::The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00179-8
更新日期:2000-10-01 00:00:00
abstract::A comparison has been made of two methods for studying the immune response of human lymphocytes to antigens not experienced in vivo. In the first method, the sensitization-restimulation assay (or S/R test), lymphocytes from blood were sensitized to antigen in bulk cultures and then redistributed into microtiter plates...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90076-4
更新日期:1984-06-01 00:00:00
abstract::Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.04.003
更新日期:2005-07-01 00:00:00
abstract::On waiting lists, transplant candidates are routinely screened for potentially harmful complement-fixing alloantibodies using complement-dependent cytotoxicity (CDC) panel-reactive antibody (PRA) testing. We have recently developed a novel cell-independent assay for assessment of complement-activating panel reactivity...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.12.007
更新日期:2005-05-01 00:00:00
abstract::Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients an...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.12.019
更新日期:2012-04-01 00:00:00
abstract::Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.01.002
更新日期:2013-05-01 00:00:00
abstract::The aim of this study was to determine the prognostic significance of soluble human leukocyte antigen (HLA) class I (sHLA-I) and HLA-G molecules in lung cancer patients. A total of 23 small-cell lung cancer (SCLC) and 114 non-small-cell lung cancer (NSCLC) patients, including 55 adenocarcinoma, 46 squamous cell carcin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.015
更新日期:2010-05-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is an anti-inflammatory and immunosuppressive molecule that can modulate immune cell activation. The role of HLA-G in tuberculosis, an immune-mediated and chronic bacterial disease remains to be elucidated. We investigated the expression profile of soluble and membrane bound HLA-G in ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.01.004
更新日期:2016-09-01 00:00:00
abstract::The role of HLA antigens in lymphocyte differentiation is strongly suggested by the existence of a recently identified immunodeficiency associated with, and probably resulting from, the lack of expression of HLA-A, B, and C antigens as well as beta2 microglobulin on various cells of hematopoietic origin. This "bare ly...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90061-6
更新日期:1981-03-01 00:00:00
abstract::Identification of mycobacterial antigens that are recognized by CD4+ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases. Our studies in this direction have shown that several recombinant mycobacteri...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00137-8
更新日期:2000-02-01 00:00:00
abstract::When lymphocytes of healthy donors were incubated with penicillin and washed before HLA typing, the cytotoxic reactivity of some typing sera with their corresponding antigen was blocked. When the penicillin was added to the cytotoxicity assay at different times, competition between penicillin and alloantiserum for bin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90033-7
更新日期:1982-08-01 00:00:00
abstract::The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(83)90065-4
更新日期:1983-02-01 00:00:00
abstract::The presence of complement fixing anti-human leukocyte antigen (HLA) antibodies in the circulation of organ transplant recipients may result in heart allograft rejection. Here, we assessed the clinical impact of pre- and post-transplantation allosensitization on long-term survival of heart allografts. Sequential sampl...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.06.015
更新日期:2009-10-01 00:00:00
abstract::The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00175-4
更新日期:1997-09-15 00:00:00
abstract::Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellu...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.03.008
更新日期:2017-01-01 00:00:00
abstract::Peptide binding to HLA-DR molecules in intracellular compartments is facilitated by HLA-DM molecules, present in most types of antigen-presenting cells. Allorecognition of DR specificities represents a form of T cell recognition of the MHC-peptide complex which in some cases is influenced by peptide binding. DRA and D...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00263-2
更新日期:1998-02-01 00:00:00
abstract::The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)90090-6
更新日期:1994-09-01 00:00:00
abstract::The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN pos...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.10.020
更新日期:2007-02-01 00:00:00
abstract::A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00143-2
更新日期:1997-08-01 00:00:00
abstract::This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.018
更新日期:2008-11-01 00:00:00