Abstract:
:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have been identified. These alleles have been accordingly named A4, A5, A6, A7, A9, A10, and A5.1, and the sizes are, respectively, 179 bp, 182 bp, 186 bp, 189 bp, 194 bp, 197 bp, and 185 bp. We analyzed 1100 Italian subjects for MICA exon 5 microsatellite polymorphism. A new peak corresponding to 191-bp size was observed in one individual, and we confirmed the presence of new polymorphism in exon 5 by sequencing, which consisted of eight GCT repeats. We named this allele, as a current nomenclature, MICA8.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni Adoi
10.1016/j.humimm.2006.10.007subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1005-7issue
12eissn
0198-8859issn
1879-1166pii
S0198-8859(06)00553-2journal_volume
67pub_type
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