MUC1 is a novel costimulatory molecule of human T cells and functions in an AP-1-dependent manner.

abstract：:The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...

journal_title：Human immunology

authors： Acton RT,Dasanayake AP,Harrison RA,Li Y,Roseman JM,Go RC,Wiener H,Caufield PW

更新日期：1999-10-01 00:00:00

abstract：:We compared the immunohistochemical reaction patterns of HLA-G-specific antibodies 87G, 4H84, G233, 16G1, and BFL.1 on human placentas under three different preparative conditions and on cryosections of other human tissues. Human and murine cell lines, either naturally expressing or transfected with HLA-G, were analyz...

journal_title：Human immunology

authors： Blaschitz A,Hutter H,Leitner V,Pilz S,Wintersteiger R,Dohr G,Sedlmayr P

更新日期：2000-11-01 00:00:00

abstract：:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

journal_title：Human immunology

authors： Miceli MC,Barry TS,Finn OJ

更新日期：1988-07-01 00:00:00

abstract：:Alloantigen specific CD8+CD28- T suppressor (TS) cells differ from naturally occurring CD4+CD25+ T-regulatory (natural TR) cells not only by their phenotype but also by their mechanism of action. Natural TR have been extensively studied, leading to the identification of characteristic "molecular markers" such as Forkh...

journal_title：Human immunology

authors： Scotto L,Naiyer AJ,Galluzzo S,Rossi P,Manavalan JS,Kim-Schulze S,Fang J,Favera RD,Cortesini R,Suciu-Foca N

更新日期：2004-11-01 00:00:00

abstract：:Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...

journal_title：Human immunology

authors： Pook MA,Woodcock V,Tassabehji M,Campbell RD,Summers CW,Taylor M,Strachan T

更新日期：1991-10-01 00:00:00

abstract：:Indirect immunofluorescence staining with monoclonal antibodies has shown a differential distribution of HLA-DR, DQ, and DP antigens in normal tissues of nonlymphoid origin. The distribution of HLA-DP antigens is similar to that of HLA-DR antigens, while that of HLA-DQ antigens is more restricted. Malignant transforma...

journal_title：Human immunology

authors： Natali P,Bigotti A,Cavalieri R,Nicotra MR,Tecce R,Manfredi D,Chen YX,Nadler LM,Ferrone S

更新日期：1986-02-01 00:00:00

abstract：UNLABELLED:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate t...

journal_title：Human immunology

authors： Oweira H,Lahdou I,Daniel V,Opelz G,Schmidt J,Zidan A,Mehrabi A,Sadeghi M

更新日期：2016-10-01 00:00:00

abstract：:Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...

journal_title：Human immunology

authors： Sanchez C,Baier C,Colle JG,Chelbi R,Rihet P,Le Treut T,Imbert J,Sébahoun G,Venton G,Costello RT

更新日期：2015-09-01 00:00:00

abstract：:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating t...

journal_title：Human immunology

authors： Cifuentes RA,Rojas-Villarraga A,Anaya JM

更新日期：2011-07-01 00:00:00

abstract：:Immunoglobulin idiotypes (Id) of malignant B cells represent highly specific markers which can be used for vaccination. PCR-amplification of immunoglobulin genes enables the rapid production of large amounts of Id vaccines. However, the separate amplification and subsequent recombination of heavy and light chains can ...

journal_title：Human immunology

authors： Terness P,Welschof M,Moldenhauer G,Jung M,Moroder L,Kirchhoff F,Kipriyanov S,Little M,Opelz G

更新日期：1997-08-01 00:00:00

abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...

journal_title：Human immunology

authors： Di Rosa F,D'Oro U,Ruggiero G,Racioppi L,Acquaviva A,Ferrone S,Fontana S,Zappacosta S

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...

journal_title：Human immunology

authors： Shehjar F,Afroze D,Misgar RA,Malik SA,Laway BA

更新日期：2018-04-01 00:00:00

abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

journal_title：Human immunology

authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

更新日期：2002-09-01 00:00:00

abstract：:Two groups of residents in an endemic area of Leishmania major infection in Iran with positive leishmanin skin tests who were either asymptomatic or had healed cutaneous leishmaniasis lesions were compared with respect to their T helper responses. The percentages of regulatory T cells (Treg; CD4(+)CD25(high) FoxP3(+))...

journal_title：Human immunology

authors： Bahrami F,Darabi H,Riazi-Rad F,Khaze V,Ajdary S,Alimohammadian MH

更新日期：2014-10-01 00:00:00

abstract：:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...

journal_title：Human immunology

authors： Harari A,Zimmerli SC,Pantaleo G

更新日期：2004-05-01 00:00:00

abstract：:Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...

journal_title：Human immunology

authors： Greenshields AL,Liwski RS

更新日期：2019-07-01 00:00:00

abstract：:Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...

journal_title：Human immunology

authors： Lesport E,Baudhuin J,LeMaoult J,Sousa S,Doliger C,Carosella ED,Favier B

更新日期：2009-12-01 00:00:00

abstract：:This study aimed at evaluating the functional activation and activating receptors expression on resting, short- and long-term NK and NK-like T cells from blood of ovarian neoplasia patients. Blood from patients with adnexal benign alterations (n = 10) and ovarian cancer (grade I-IV n = 14) were collected after signed ...

journal_title：Human immunology

authors： da Silva RF,Petta CA,Derchain SF,Alici E,Guimarães F

更新日期：2014-08-01 00:00:00

abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...

journal_title：Human immunology

authors： Pesando JM,Nadler LM,Lazarus H,Tomaselli KJ,Stashenko P,Ritz J,Levine H,Yunis EJ,Schlossman SF

更新日期：1981-08-01 00:00:00

abstract：:The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

journal_title：Human immunology

authors： Zachary AA,Delaney NL,Lucas DP,Leffell MS

更新日期：2001-03-01 00:00:00

abstract：:A comprehensive system for genetic typing of the HLA class I A locus is described, based on PCR amplification and typing with nonradioactively labeled SSO probes. Exons 1-3 of the A locus are amplified and typing is performed with a set of 30 nonradioactively labeled oligonucleotide probes. This system resolves 34 of ...

journal_title：Human immunology

authors： Allen M,Liu L,Gyllensten U

更新日期：1994-05-01 00:00:00

abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...

journal_title：Human immunology

authors： Shah AS,Leffell MS,Lucas D,Zachary AA

更新日期：2009-02-01 00:00:00

abstract：:HLA analysis of the family of a renal transplant patient revealed an extremely rare condition. On repeated typings the only demonstrable HLA antigens shown in the propositus were from the maternal haplotype, HLA-A11,-B46,-CW1,-DR14,-DQ1. No paternal antigens could be demonstrated either by serologic or by DNA-typing m...

journal_title：Human immunology

authors： van den Berg-Loonen EM,Savelkoul P,van Hooff H,van Eede P,Riesewijk A,Geraedts J

更新日期：1996-01-01 00:00:00

abstract：:The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

journal_title：Human immunology

authors： Gavioli R,Zhang QJ,Masucci MG

更新日期：1996-08-01 00:00:00

abstract：:A two stage PCR-SSOP typing procedure, that permitted HLA-B allele assignment, was applied to DNA samples obtained from six diverse populations -Brazilian, Mexican (Series and Mestizos), Cuban (Caucasoid and Mulatto), South African Zulu, Omani, and Singapore Chinese. HLA-B allele frequencies and HLA-A/B two locus hapl...

journal_title：Human immunology

authors： Williams F,Meenagh A,Darke C,Acosta A,Daar AS,Gorodezky C,Hammond M,Nascimento E,Middleton D

更新日期：2001-06-01 00:00:00

abstract：:Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...

journal_title：Human immunology

authors： Adamashvili I,McVie R,Gelder F,Gautreaux M,Jaramillo J,Roggero T,McDonald J

更新日期：1997-07-01 00:00:00

abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...

journal_title：Human immunology

authors： Zachary AA,Bias WB,Johnson A,Rose SM,Leffell MS

更新日期：2001-10-01 00:00:00

abstract：:The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...

journal_title：Human immunology

authors： Traks T,Karelson M,Reimann E,Rätsep R,Silm H,Vasar E,Kõks S,Kingo K

更新日期：2016-05-01 00:00:00

abstract：:rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 20...

journal_title：Human immunology

authors： Wang J,Zhang J,Shen J,Hu D,Yan G,Liu X,Xu X,Pei L,Li Y,Sun C

更新日期：2014-04-01 00:00:00

abstract：:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopo...

journal_title：Human immunology

authors： Nestorowicz K,Bogacz A,Bukowska A,Chraplak M,Czerwiński J,Góralski M,Gronkowski M,Jopek K,Kniżewski Ł,Kolasiński M,Kowalski ML,Nowak J,Sowiński M,Wróblewska-Kabba S,Tymoniuk B,Dudkiewicz M

更新日期：2020-01-01 00:00:00