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HLA class II molecules transduce accessory signals affecting the CD3 but not the interleukin-2 activation pathway in T blasts.

Abstract：

:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by analyzing in parallel the IL-2- and CD3-driven activation pathways. The results indicate that the cross-linking of class II and CD3 molecules significantly increased the CD3-mediated T-blast proliferation, while no effect was observed on the IL-2-driven cell activation. This phenomenon was not confined to either CD4+ or CD8+ subsets nor was specifically affected by CD45 triggering. Biochemical studies showed that signaling via MHC class II molecules in T blasts led to PKC membrane translocation and IP accumulation. The simultaneous triggering of CD3 and HLA class II molecules led to a synergistic effect on IP accumulation but did not increase the CD3-mediated PKC membrane translocation. Our data suggest that HLA class II molecules are involved in T-cell-T-cell interactions and can mediate accessory signals, affecting the T-lymphocyte activation state.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Di Rosa F,D'Oro U,Ruggiero G,Racioppi L,Acquaviva A,Ferrone S,Fontana S,Zappacosta S

doi

10.1016/0198-8859(93)90552-c

subject

Has Abstract

pub_date

1993-12-01 00:00:00

pages

251-60

issue

4

eissn

0198-8859

issn

1879-1166

pii

0198-8859(93)90552-C

journal_volume

38

pub_type

杂志文章

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