Abstract:
:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopoietic stem cell transplantation. The donors were recruited for registry and not for any other purpose including controls in a disease association study. The population sample was collected in various regions of Poland including all voivodships. The data regarding the degree of relatedness among individuals in the sample were not collected. Typings were supported by public funds as a part of the Polish National Program for Transplant Medicine Development. HLA frequency data are available in the Allele Frequencies Net Database.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Nestorowicz K,Bogacz A,Bukowska A,Chraplak M,Czerwiński J,Góralski M,Gronkowski M,Jopek K,Kniżewski Ł,Kolasiński M,Kowalski ML,Nowak J,Sowiński M,Wróblewska-Kabba S,Tymoniuk B,Dudkiewicz Mdoi
10.1016/j.humimm.2019.12.005subject
Has Abstractpub_date
2020-01-01 00:00:00pages
49-51issue
2-3eissn
0198-8859issn
1879-1166pii
S0198-8859(19)31234-0journal_volume
81pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.02.005
更新日期:2019-07-01 00:00:00
abstract::Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.03.015
更新日期:2011-07-01 00:00:00
abstract::Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.04.003
更新日期:2005-07-01 00:00:00
abstract::In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90076-0
更新日期:1987-04-01 00:00:00
abstract::Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.006
更新日期:2010-05-01 00:00:00
abstract::Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2020.05.008
更新日期:2020-08-01 00:00:00
abstract::The eotaxin gene family (eotaxin, eotaxin-2, and eotaxin-3) has been implicated in the recruitment of eosinophils, basophiles and Th2 lymphocytes that is a central aspect of allergic diseases. We previously suggested that Eo2+179T>C and Eo2+275C>T of the eotaxin-2, and Eo3+2497T>G of the eotaxin-3 were significantly a...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.01.002
更新日期:2005-03-01 00:00:00
abstract::A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(95)00168-9
更新日期:1996-02-01 00:00:00
abstract::Regulatory T cells (T(reg) cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), h...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.016
更新日期:2008-11-01 00:00:00
abstract::To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(96)00079-1
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of asthma and to generate SNP to gene to pathway hypotheses. METHODS:SNPs that met a threshold of p ≤ 0.001 in a genome-wide association study (GWAS) dataset of asthma, which in...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.11.003
更新日期:2013-02-01 00:00:00
abstract::Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00246-9
更新日期:2001-02-01 00:00:00
abstract::In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90035-0
更新日期:1982-06-01 00:00:00
abstract::Heart transplant rejection is routinely defined by histological evaluation of endomyocardial biopsies (EMB). As elevated levels of donor derived sHLA (dsHLA) can be detected in the serum of transplanted patients just before or during rejection, quantification of donor specific soluble counterparts of HLA Class I (sHLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00010-5
更新日期:1999-05-01 00:00:00
abstract::The 5' cis-regulatory region of the CCR5 gene exhibits a strong signature of balancing selection in several human populations. Here we analyze the polymorphism of this region in Amerindians from Amazonia, who have a complex demographic history, including recent bottlenecks that are known to reduce genetic variability....
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.05.022
更新日期:2010-09-01 00:00:00
abstract::The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. How...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.07.008
更新日期:2010-10-01 00:00:00
abstract::Little is known about the etiologies of diseases associated with circulating antineutrophil cytoplasm autoantibodies (ANCA), such as primary vasculitides and inflammatory bowel diseases. However, the understanding of immune mechanisms supposedly involved in the pathogenesis of these diseases is still growing. In the p...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2003.09.013
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). METHODS:The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G ...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2014.02.020
更新日期:2014-05-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.01.005
更新日期:2011-04-01 00:00:00
abstract::The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90069-4
更新日期:1989-05-01 00:00:00
abstract::From a human cDNA library constructed from consanguineous HLA-homozygous cell line AKIBA (HLA-A24, Bw52, DR2, Dw12, Cp63 Cp63: a new DP type), cDNA clones encoding the heavy and light chains of an HLA-DP Cp63 alloantigen were isolated and analyzed by restriction enzyme mapping and nucleotide sequence determination. Al...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(86)90286-7
更新日期:1986-11-01 00:00:00
abstract::The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00122-0
更新日期:1999-03-01 00:00:00
abstract::Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.011
更新日期:2011-10-01 00:00:00
abstract::IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00124-9
更新日期:1995-05-01 00:00:00
abstract::The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90241-1
更新日期:1985-12-01 00:00:00
abstract::Only 10% of persons infected with Mycobacterium tuberculosis develop clinical tuberculosis (TB), indicating the existence of host genetic factors regulating disease expression. We investigated the association of human leukocyte antigen (HLA) class II genes with the susceptibility to pulmonary TB in Koreans, with speci...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.08.242
更新日期:2005-10-01 00:00:00
abstract::Many studies have shown that Human leukocyte antigen (HLA) class I alleles are associated with the development of various cancers. However, its role in hepatocellular carcinoma (HCC) is still unknown. To investigate whether HLA class I allelic polymorphism is related to the development of hepatitis B virus(HBV)-associ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.02.007
更新日期:2013-06-01 00:00:00
abstract::The purpose of this study was to examine the expression of human leukocyte antigen-G (HLA-G) in patients with systemic lupus erythematosus (SLE) and its relation with interleukin-10 (IL-10) production. The study included 50 female SLE patients and 59 healthy female donors. HLA-G expression in peripheral blood and cuta...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.11.001
更新日期:2008-01-01 00:00:00