Abstract：
:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxic against one or more of the HLA antigens for which the kidney donor and the recipient were mismatched. Traditionally, cytotoxicity in allograft rejection has been attributed to CD8-positive cytotoxic T lymphocytes (CTLs) directed against class I alloantigens. Cell lines described here are mixtures of distinct CD4-antigen-positive and CD8-antigen-positive subpopulations, and exhibit class I- as well as class II-directed killing. Using a cell line that demonstrates class II-directed cytotoxicity and a set of class II deletion mutants as target cells, we show that class II antigens, in particular HLA-DP, can serve as targets in renal allograft rejection. The role of CD4-positive CTLs was shown by analysis of clonal populations or sorted CD8-positive and CD4-positive subpopulations. In several instances we have obtained cell lines from serial biopsies performed on the same patient at distinct time points during an ongoing rejection. Comparisons of the phenotype, function, and specificities allow for speculation regarding T-cell population dynamics within the rejection response.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Miceli MC,Barry TS,Finn OJdoi
10.1016/0198-8859(88)90028-6subject
Has Abstractpub_date
1988-07-01 00:00:00pages
185-98issue
3eissn
0198-8859issn
1879-1166pii
0198-8859(88)90028-6journal_volume
22pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：UNLABELLED:Vesicoureteral reflux (VUR) is a common childhood problem, causing renal wounds and escalating the risk of renal deficiency and hypertension. A vast literature exists suggesting that genetic variations play a significant role in the pathogenesis of VUR. The aim of the present study was to estimate whether ge...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2012.09.005
更新日期：2013-01-01 00:00:00
abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00075-5
更新日期：1998-11-01 00:00:00
abstract：:We compared the immunohistochemical reaction patterns of HLA-G-specific antibodies 87G, 4H84, G233, 16G1, and BFL.1 on human placentas under three different preparative conditions and on cryosections of other human tissues. Human and murine cell lines, either naturally expressing or transfected with HLA-G, were analyz...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(00)00207-x
更新日期：2000-11-01 00:00:00
abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2012.10.027
更新日期：2013-02-01 00:00:00
abstract：:Platelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(96)00019-5
更新日期：1996-04-01 00:00:00
abstract：:The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90090-6
更新日期：1994-09-01 00:00:00
abstract：:To elucidate the residues important for the binding of peptides to HLA-Cw3, a substitutional analysis of two HLA-Cw*0304-binding peptides was performed. The optimal registry and length for a Cw3-restricted epitope from HIV-1 p24gag was determined to be a nonamer, p24gag 144-152. Substituted analogs of this nonamer pep...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00053-6
更新日期：1998-08-01 00:00:00
abstract：:The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.10.004
更新日期：2016-01-01 00:00:00
abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.04.007
更新日期：2010-07-01 00:00:00
abstract：:Minor lymphocyte stimulating locus (Mls) gene products in association with mouse major histocompatibility complex (MHC) class II molecules are known to determine the repertoire of T-cell receptor (TCR) in mature T cells. In order to test whether human class II molecules can present mouse Mls, HLA-DQ beta transgenic mi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(91)90048-e
更新日期：1991-05-01 00:00:00
abstract：:Human leukocyte antigen-G (HLA-G) is an anti-inflammatory and immunosuppressive molecule that can modulate immune cell activation. The role of HLA-G in tuberculosis, an immune-mediated and chronic bacterial disease remains to be elucidated. We investigated the expression profile of soluble and membrane bound HLA-G in ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.01.004
更新日期：2016-09-01 00:00:00
abstract：:The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of He...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.07.003
更新日期：2016-10-01 00:00:00
abstract：:Cord blood, donated by mothers after the birth of their children, has become an accepted source of related and unrelated hematopoietic stem cells for marrow reconstitution. We estimate that some 7-8000 unrelated-donor cord blood transplants have been performed worldwide since 1993. The development of cord blood as a s...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2006.03.015
更新日期：2006-06-01 00:00:00
abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.09.004
更新日期：2007-01-01 00:00:00
abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.03.005
更新日期：2008-06-01 00:00:00
abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.11.014
更新日期：2010-02-01 00:00:00
abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00152-g
更新日期：1995-07-01 00:00:00
abstract：:This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft. ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2018.01.016
更新日期：2018-05-01 00:00:00
abstract：:Polymorphisms of interleukin-23 receptor (IL23R) gene have recently been reported to be associated with the susceptibility to several immune-related diseases. The aim of this study was to determine the association of IL23R polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, a disease presumably mediated by autoimm...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.01.026
更新日期：2010-04-01 00:00:00
abstract：:The compatibility of HLA-A,-B expression between mother and offspring was examined in 410 families serologically tissue typed within a single transplant lab from 1972 thru 1982. The study group included 410 mothers of 1719 children (range 2-13/mother), with 352 one-father and 58 multiple-father families There were sev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(84)90072-7
更新日期：1984-11-01 00:00:00
abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.01.002
更新日期：2013-05-01 00:00:00
abstract：:The genetic polymorphism of the fourth component of human complement, C4, was studied in 945 unrelated Caucasian individuals. A third allele of the C4F (Rodgers) locus, termed C4F1 was demonstrated. This allele is characterized using immunofixation electrophoresis, by the presence of an additional fast-moving anodal b...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(80)90006-3
更新日期：1980-07-01 00:00:00
abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(99)00169-x
更新日期：2000-01-01 00:00:00
abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.06.025
更新日期：2013-10-01 00:00:00
abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90046-3
更新日期：1989-01-01 00:00:00
abstract：:The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(98)00059-7
更新日期：1998-09-01 00:00:00
abstract：:The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous. In this study, we performed a more precise estimation of the relationship by a ...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2011.03.019
更新日期：2011-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). METHODS:The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G ...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2014.02.020
更新日期：2014-05-01 00:00:00
abstract：:In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(85)90017-5
更新日期：1985-06-01 00:00:00
abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(80)90005-1
更新日期：1980-07-01 00:00:00
