Abstract：
UNLABELLED:Vesicoureteral reflux (VUR) is a common childhood problem, causing renal wounds and escalating the risk of renal deficiency and hypertension. A vast literature exists suggesting that genetic variations play a significant role in the pathogenesis of VUR. The aim of the present study was to estimate whether genetic polymorphisms of IL-19 (GC rs2243158, AT rs2243158) and IL-20 (AG rs2981573, TG rs2981572) genes are involved in the development of VUR. MATERIALS AND METHODS:The tetra amplification mutation refractory system-polymerase chain reaction (Tetra-ARMS PCR) was applied for analyzing four polymorphic sites of IL-19 (GC rs2243158, AT rs2243158) and IL-20 (AG rs2981573, TG rs2981572) genes in 110 healthy controls and 124 VUR children. RESULTS:A significant association was found between the combined genotypes of IL19GC+CC and IL20TG+GG and increased risk of VUR (OR = 1.90, 95% CL, 1.06-3.41; OR=1.87, 95% CL, 1.06-3.29, respectively). The frequency of allele G in both sites of IL-20 (IL20AG rs2981573 and IL20TG, rs2981572) showed a statistically significant difference (p = 0.01) between cases and controls in comparison with the wild type. The combined haplotype analysis of IL-19 and IL-20 polymorphic sites revealed that HT2, HT3 and HT5 haplotypes marginally increased the risk of VUR, but not statistically significantly. Gene-gene interaction data of IL-19 (GC rs2243158, AT rs2243158) and IL-20 (AG rs2981573, TG rs2981572) in various genotype patterns highlighted the fact that most of the genotype combinations increased the risk of disease insignificantly. CONCLUSION:This is the first evidence regarding IL-19 and IL-20 cytokine genes polymorphism and risk of VUR, suggesting the need for further study with large sample size and in different populations to confirm the presented data.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Kordi-Tamandani DM,Sadeghi-Bojd S,Torkamanzehi Adoi
10.1016/j.humimm.2012.09.005subject
Has Abstractpub_date
2013-01-01 00:00:00pages
131-4issue
1eissn
0198-8859issn
1879-1166pii
S0198-8859(12)00556-3journal_volume
74pub_type
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