Abstract：
:Sera obtained from multiparous women and some of other origin contain antibodies which react with antigens on T cell subsets. These antibodies recognize two distinct diallelic systems, one of which is mainly present on T gamma cells while the other is present on T mu cells. The sera that reacted with the T gamma cells formed a pattern consistent with that of a diallelic system which we have called TCA system with alleles TCA 1 and TCA 2; the sera which reacted with the T mu cells formed a pattern consistent with another diallelic system, independent from TCA, which we have designated the TCB system, with alleles TCB 1 and TCB 2.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
van Leeuwen A,Festenstein H,van Rood JJdoi
10.1016/0198-8859(82)90011-8subject
Has Abstractpub_date
1982-04-01 00:00:00pages
109-21issue
2eissn
0198-8859issn
1879-1166pii
0198-8859(82)90011-8journal_volume
4pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00126-3
更新日期：2000-03-01 00:00:00
abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00094-9
更新日期：1999-01-01 00:00:00
abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.06.003
更新日期：2007-09-01 00:00:00
abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.11.003
更新日期：2007-04-01 00:00:00
abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(88)90087-0
更新日期：1988-02-01 00:00:00
abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.02.001
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.05.009
更新日期：2018-08-01 00:00:00
abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00124-9
更新日期：1995-05-01 00:00:00
abstract：:The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2016.04.004
更新日期：2016-11-01 00:00:00
abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.08.267
更新日期：2013-12-01 00:00:00
abstract：:Using the soft-agar colony assay, we have generated three MT3-associated clones: HJ1, HJ13, and HJ39, from an MLR combination of two unrelated individuals. Another clone, HJ37, appeared to recognize a novel HLA-D determinant. PLT inhibition studies with monoclonal anti-Ia-like antibodies (Mab) were conducted on clones...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(83)90066-6
更新日期：1983-02-01 00:00:00
abstract：:Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.06.007
更新日期：2018-09-01 00:00:00
abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.10.002
更新日期：2020-12-01 00:00:00
abstract：:The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized app...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(96)00228-5
更新日期：1996-12-01 00:00:00
abstract：:To evaluate the role of tumor necrosis factor-alpha (TNF-alpha) gene as susceptibility marker for spondyloarthritis (SpA), two polymorphisms (-238 and -308 positions) were analyzed in 229 patients with SpA (113 with ankylosing spondylitis [AS], 92 with undifferentiated SpA [U-SpA], 24 with reactive arthritis), and 169...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.07.009
更新日期：2006-10-01 00:00:00
abstract：:Little is known about the etiologies of diseases associated with circulating antineutrophil cytoplasm autoantibodies (ANCA), such as primary vasculitides and inflammatory bowel diseases. However, the understanding of immune mechanisms supposedly involved in the pathogenesis of these diseases is still growing. In the p...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2003.09.013
更新日期：2004-01-01 00:00:00
abstract：:Nucleotide sequences of alleles encoding four serologically defined splits of the HLA-A10 group, A26.1, A26.3, A26.4, and A10SA, were determined. It was confirmed that the alleles coding for A26.1 and A26.3 are identical with A*2602 and A*2601, respectively. On the other hand, alleles for A26.4 and A10SA are thus far ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90263-1
更新日期：1994-03-01 00:00:00
abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(80)90005-1
更新日期：1980-07-01 00:00:00
abstract：:Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(02)00396-8
更新日期：2002-06-01 00:00:00
abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90069-4
更新日期：1989-05-01 00:00:00
abstract：:Few data are available concerning immune factors involved in the occurrence of new onset diabetes after transplantation (NODAT). Our objective was to determine an immune profile associated with the subsequent development of NODAT. The secondary objective was to build a predictive model of NODAT. We studied a prospecti...
journal_title：Human immunology
pub_type： 临床试验,杂志文章
doi：10.1016/j.humimm.2019.08.006
更新日期：2019-11-01 00:00:00
abstract：:HLA-DQA1 typing of the 4AOHW cell panel is presented using a novel strategy that exploits both intron and exon polymorphisms. Intron sequences adjacent to the variable HLA-DQA1 second exon exhibit stable polymorphisms that are specific for locus alleles and certain suballelic DR/DQ haplotypes. A PCR-RFLP method has be...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90520-b
更新日期：1993-09-01 00:00:00
abstract：:Recent studies have suggested a clinical significance to the detection of anti-major histocompatibility complex class I-related chain A (MICA) antibodies in transplantation. We have developed an eplet-based version of the HLAMatchmaker algorithm to assess the epitope specificity of these antibodies. Molecular viewing ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.10.003
更新日期：2008-12-01 00:00:00
abstract：:The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.05.001
更新日期：2017-01-01 00:00:00
abstract：:DNA sequences that distinguish the subsets of HLA-DR4 are also found on several other alleles. This makes typing of heterozygotes with oligonucleotide probes quite impractical. We have therefore developed a procedure in which, in a first step, DNA of the genes to be analyzed is amplified selectively, using group-speci...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90094-6
更新日期：1990-01-01 00:00:00
abstract：:Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.05.011
更新日期：2011-10-01 00:00:00
abstract：:HLA exhibits the most extensive polymorphism of any of the known human genes and is known as a genetic marker which allows genetic background of many diseases and physical phenomena. In this study, we, therefore, tried to investigate the regulation of HLA polymorphism and peak bone mass (PBM) in order to elucidate the...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00009-3
更新日期：1998-04-01 00:00:00
abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(97)00175-4
更新日期：1997-09-15 00:00:00
abstract：:In the present study, we explored the specific requirements for lysis of human activated T cells by CD4+ CTLs. This was achieved by using human CD4+ T cell lines or clones specific for a peptidic fragment of influenza virus as both CTL effectors and target T cells (TTCs). Our results further establish that human activ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(92)90094-4
更新日期：1992-09-01 00:00:00
abstract：:Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(91)90106-j
更新日期：1991-10-01 00:00:00
