当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Human HLA-DQ beta chain presents minor lymphocyte stimulating locus gene products and clonally deletes TCR V beta 6+, V beta 8.1+ T cells in single transgenic mice.

Human HLA-DQ beta chain presents minor lymphocyte stimulating locus gene products and clonally deletes TCR V beta 6+, V beta 8.1+ T cells in single transgenic mice.

Abstract：

:Minor lymphocyte stimulating locus (Mls) gene products in association with mouse major histocompatibility complex (MHC) class II molecules are known to determine the repertoire of T-cell receptor (TCR) in mature T cells. In order to test whether human class II molecules can present mouse Mls, HLA-DQ beta transgenic mice were generated. The expression and function of the DQ beta transgene were studied in the progeny of one selected founder which was H-2f and H-2E negative. In these mice, DQ beta molecules pairing with mouse A alpha chain and invariant chain are expressed on the cell surface in a tissue-specific manner. When the DQ beta gene was bred into the Mls-1a strain DBA/1 (H-2q), T cells bearing V beta 6 and V beta 8.1 TCR were clonally deleted in the thymus of DQ beta+ transgenics but not in DQ beta-negative full sibs. Thus, the data presented here clearly demonstrate that the human MHC DQ beta chain can present Mls in the clonal deletion of T cells. Our results also suggest the requirement for an interaction between CD4 and class II molecules (alpha chain) for clonal deletion of T cells to occur.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Zhou P,Anderson GD,Savarirayan S,Inoko H,David CS

doi

10.1016/0198-8859(91)90048-e

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

47-56

issue

1

eissn

0198-8859

issn

1879-1166

pii

0198-8859(91)90048-E

journal_volume

31

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Influence of the TNFSF4 rs1234315 polymorphism in the susceptibility to systemic lupus erythematosus and rheumatoid arthritis.

    abstract：OBJECTIVES:The tumour necrosis factor superfamily 4 (TNFSF4) is a candidate gene for autoimmune diseases. We investigated the relationship of this gene with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Chinese Guangxi population. METHODS:A total of 294 patients with SLE, 210 with RA, and 282 h...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.11.006

    authors： Xu J,He Y,Wang J,Li X,Huang L,Li S,Qin X

    更新日期：2019-04-01 00:00:00

  • High frequency of the TCRBV20S1 null allele in the Sardinian population.

    abstract：:Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.01.011

    authors： Bonfigli S,Fozza C,Contini S,Buzzetti R,Cucca F,Longinotti M

    更新日期：2007-05-01 00:00:00

  • Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.

    abstract：:The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2018.01.003

    authors： Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M

    更新日期：2018-03-01 00:00:00

  • MICA A8: a new allele within MHC class I chain-related A transmembrane region with eight GCT repeats.

    abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.10.007

    authors： Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni A

    更新日期：2006-12-01 00:00:00

  • Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studies.

    abstract：:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating t...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2011.03.012

    authors： Cifuentes RA,Rojas-Villarraga A,Anaya JM

    更新日期：2011-07-01 00:00:00

  • Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.

    abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.12.014

    authors： Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

    更新日期：2004-04-01 00:00:00

  • Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals.

    abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(96)00080-8

    authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

    更新日期：1996-06-01 00:00:00

  • GvHD risk assessment in hematopoietic stem cell transplantation: role of cytokine gene polymorphisms and an in vitro human skin explant model.

    abstract：:This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00324-x

    authors： Dickinson AM,Cavet J,Cullup H,Wang XN,Sviland L,Middleton PG

    更新日期：2001-11-01 00:00:00

  • Identification of single nucleotide polymorphisms in the tumor necrosis factor (TNF) and TNF receptor superfamily in the Korean population.

    abstract：:The tumor necrosis factor (TNF) and TNF receptor (TNF-TNFR) superfamily plays crucial roles in immune regulation and host immune responses. The superfamily has been also associated with many immune-mediated diseases such as asthma, rheumatoid arthritis, inflammatory bowel disease, and diabetes. In order to investigate...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2004.04.005

    authors： Cho SM,Kim J,Ryu HJ,Kim JJ,Kim HH,Park JH,Kim HT,Kim KH,Cho HY,Oh B,Park C,Kimm K,Jo I,Lee JE,Shin HD,Lee JK

    更新日期：2004-07-01 00:00:00

  • Impaired circulating CD56dim NK cells are associated with decompensation of HBV-related cirrhosis.

    abstract：:NK cells play an important role in immune regulation and defense of infection, but their characteristics in patients with decompensated cirrhosis and their relationship with liver function remain unclear. We studied the functional properties of NK cells (including CD56dim NK and CD56bright NK cells) in patients with H...

    journal_title：Human immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.humimm.2019.11.006

    authors： Jiang Y,Chen Y,Chen L,Yao W,Guan J,Liu X,Wei X,Lin X

    更新日期：2020-01-01 00:00:00

  • Genetic diversity of HLA system in a population from Guerrero, Mexico.

    abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two E...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.05.015

    authors： Juárez-Nicolás F,Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Ortega-Yáñez A,Arrieta-Bolaños E,Clayton S,Bravo-Acevedo A,Arrazola-García MA,Immel A,Juárez-Barreto V,Benítez-Arvizu G,Vega-Martínez MDR,García-Álvarez R,

    更新日期：2020-09-01 00:00:00

  • Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

    abstract：:Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.12.008

    authors： Tassiulas I,Park-Min KH,Hu Y,Kellerman L,Mevorach D,Ivashkiv LB

    更新日期：2007-03-01 00:00:00

  • Trans vivo analysis of human delayed-type hypersensitivity reactivity.

    abstract：:There are clinical situations in which it may be advantageous to monitor delayed type hypersensitivity (DTH) responses, an index of cell-mediated immunity, without exposing patients directly to the challenge antigens. For example, transplant patients may be at risk for becoming sensitized to donor antigens if injected...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00002-6

    authors： Carrodeguas L,Orosz CG,Waldman WJ,Sedmak DD,Adams PW,VanBuskirk AM

    更新日期：1999-08-01 00:00:00

  • Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides.

    abstract：:The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.12.013

    authors： Jugdé F,Boissier C,Birebent B,Vu N,D'halluin PN,Rioux-Leclercq N,Bretagne JF,Semana G,Heresebach D

    更新日期：2004-03-01 00:00:00

  • A 70 kDa MHC class I associated protein (MAP-70) identified as a receptor molecule for Coxsackievirus A9 cell attachment.

    abstract：:One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00151-8

    authors： Triantafilou M,Triantafilou K,Wilson KM

    更新日期：2000-09-01 00:00:00

  • Genetic mapping of the hemochromatosis locus on chromosome six.

    abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90005-1

    authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

    更新日期：1980-07-01 00:00:00

  • Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM.

    abstract：:Peptide binding to HLA-DR molecules in intracellular compartments is facilitated by HLA-DM molecules, present in most types of antigen-presenting cells. Allorecognition of DR specificities represents a form of T cell recognition of the MHC-peptide complex which in some cases is influenced by peptide binding. DRA and D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00263-2

    authors： Drover S,Kovats S,Masewicz S,Blum JS,Nepom GT

    更新日期：1998-02-01 00:00:00

  • Human immunodeficiency virus-1 infection protects against a Tc1-to-Tc2 shift in CD8(+) T cells.

    abstract：:Despite the reports of dysfunction of the lytic abilities of CD8(+) T cells during human immunodeficiency virus-1 (HIV-1) disease progression, the effects of infection on the noncytolytic functions of CD8(+) T cells have not been well characterized to date. We examined the effect of HIV-1 infection on the cytokine and...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.08.012

    authors： Gulzar N,Diker B,Balasubramanian S,Jiang JQ,Copeland KF

    更新日期：2011-11-01 00:00:00

  • IL10 polymorphisms associated with Behçet's disease in Chinese Han.

    abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2013.11.009

    authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

    更新日期：2014-03-01 00:00:00

  • Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII.

    abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90058-h

    authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

    更新日期：1991-11-01 00:00:00

  • Analysis of the cord blood T lymphocyte response to superantigen.

    abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00107-4

    authors： Macardle PJ,Wheatland L,Zola H

    更新日期：1999-02-01 00:00:00

  • Prediction of spurious HLA class II typing results using probabilistic classification.

    abstract：:While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.01.012

    authors： Schöfl G,Schmidt AH,Lange V

    更新日期：2016-03-01 00:00:00

  • Alloreactive lymphoid infiltrates in human heart transplants. Loss of class II-directed cytotoxicity more than 3 months after transplantation.

    abstract：:From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90071-g

    authors： Ouwehand AJ,Vaessen LM,Baan CC,Jutte NH,Balk AH,Essed CE,Bos E,Claas FH,Weimar W

    更新日期：1991-01-01 00:00:00

  • Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children.

    abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00090-7

    authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

    更新日期：1999-11-01 00:00:00

  • The clinician's guide to the anti-vaccinationists' galaxy.

    abstract：:In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...

    journal_title：Human immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.humimm.2012.03.014

    authors： Poland GA,Jacobson RM

    更新日期：2012-08-01 00:00:00

  • Genetic susceptibility to multiple sclerosis: detection of polymorphic nucleotides and an intron in the 3' untranslated region of the major histocompatibility complex class II transactivator gene.

    abstract：:The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00215-4

    authors： Rasmussen HB,Kelly MA,Clausen J

    更新日期：2001-04-01 00:00:00

  • Reduced frequency of two activating KIR genes in patients with sepsis.

    abstract：:Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.02.005

    authors： Oliveira LM,Portela P,Merzoni J,Lindenau JD,Dias FS,Beppler J,Graebin P,Alho CS,Schwartsmann G,Dal-Pizzol F,Jobim LF,Jobim M,Roesler R

    更新日期：2017-04-01 00:00:00

  • An interactive computer program for the analysis of HLA class II restriction fragment patterns.

    abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(88)90087-0

    authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

    更新日期：1988-02-01 00:00:00

  • Supermotif peptide binding and degeneracy of MHC: peptide recognition in an EBV peptide-specific CTL response with highly restricted TCR usage.

    abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00179-8

    authors： Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MG

    更新日期：2000-10-01 00:00:00

  • A new HLA Bw16 subtype defined in both Negroid and Saudi Arabian populations.

    abstract：:Serological identification of a new HLA-Bw16 subtype, B39B, was made by the analysis of reaction patterns of many alloantisera and one monoclonal antibody. The B39B pattern of reactivity was shown to be distinct from HLA-Bw38, Bw39, and 8w57. Cytotoxicity testing before and after absorption suggests that the B39B spec...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90059-x

    authors： Williams E,Alonso A,Doyle P,Okoye R,Ollier W,Festenstein H

    更新日期：1985-09-01 00:00:00