Abstract:
:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated with the antimicrobial antibody formation or particular clinical manifestations. Nine hundred ninety IBD patients and 225 healthy subjects were investigated. Sera were assayed for MBL and a panel of antimicrobial antibodies (anti-OMP, anti-Saccharomyces cerevisiae antibodies, and antiglycans) by ELISA. TLR4 and NOD2/CARD15 variants were tested by polymerase chain reaction/restriction fragment length polymorphism. Median MBL level was not significantly different between IBDs (Crohn's disease [CD]: 929; ulcerative colitis [UC]: 810 ng/ml) and the control group (1027 ng/ml), as well as the prevalence of absolute MBL deficiency (<100 ng/ml) (CD: 15.0%, UC: 18.4%, controls: 15.6%). The presence of a low MBL level (<500 ng/ml) was not associated with any of the examined serologic markers, or their combinations. In addition, there was no association with the clinical presentation, disease course, or response to treatment. TLR4 variant genotype was more common in CD patients without MBL deficiency (11% vs. 1.7%, OR: 7.29, 95% CI: 1.08-53.9, p = 0.02). We failed to confirm any association between MBL deficiency and serologic marker positivity. MBL deficiency was not predictive for clinical phenotype or disease activity in IBDs.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Papp M,Lakatos PL,Harsfalvi J,Farkas G,Palatka K,Udvardy M,Molnar T,Farkas K,Nagy F,Veres G,Lakatos L,Kovacs A,Dinya T,Kocsis AK,Papp J,Hungarian IBD Study Group.,Altorjay Idoi
10.1016/j.humimm.2010.01.012subject
Has Abstractpub_date
2010-04-01 00:00:00pages
407-13issue
4eissn
0198-8859issn
1879-1166pii
S0198-8859(10)00013-3journal_volume
71pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.02.001
更新日期:2007-06-01 00:00:00
abstract::We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.07.001
更新日期:2005-09-01 00:00:00
abstract::The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.230
更新日期:2016-10-01 00:00:00
abstract::Despite the success of the current measles vaccine in controlling disease in industrialized countries, the importance of vaccine failure has become increasingly apparent. Our objective was to determine if associations exist between seronegativity after measles vaccination and class I human leukocyte antigen (HLA) alle...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00741-3
更新日期:2003-01-01 00:00:00
abstract::rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 20...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2014.01.008
更新日期:2014-04-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00
abstract::Alloantigen specific CD8+CD28- T suppressor (TS) cells differ from naturally occurring CD4+CD25+ T-regulatory (natural TR) cells not only by their phenotype but also by their mechanism of action. Natural TR have been extensively studied, leading to the identification of characteristic "molecular markers" such as Forkh...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.09.004
更新日期:2004-11-01 00:00:00
abstract::The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90241-1
更新日期:1985-12-01 00:00:00
abstract::Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.04.004
更新日期:2011-09-01 00:00:00
abstract::The 2',5'-oligoadenylate synthetase 1 (OAS1) is one of the major interferon-inducible proteins and a critical component of the host defense system against viral infection. A single nucleotide polymorphism (SNP), rs10774671, presumably responsible for alternate splicing of this gene, has frequently been associated with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.11.011
更新日期:2013-03-01 00:00:00
abstract::Behçet's disease (BD) has been established to be associated with HLA-B51. However, it has not been revealed whether the HLA-B51 gene itself or another gene located near the HLA-B gene is directly involved in the pathogenesis of BD. Previously, using Japanese BD patients, our group has narrowed down a BD-causative gene...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00246-9
更新日期:2001-02-01 00:00:00
abstract::The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area has been limited, however, since CTL recognize minor alloantigens only in association with self-class I antigens. Thus, experiments designed to study minor all...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90035-8
更新日期:1987-05-01 00:00:00
abstract::Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.11.003
更新日期:2007-04-01 00:00:00
abstract::Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90044-6
更新日期:1981-08-01 00:00:00
abstract::Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.09.009
更新日期:2011-01-01 00:00:00
abstract::This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90115-6
更新日期:1990-11-01 00:00:00
abstract::We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.06.025
更新日期:2013-10-01 00:00:00
abstract::More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00058-2
更新日期:2003-06-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::To ascertain association of MICA with type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients were analyzed for MICA transmembrane gene polymorphism in both an association study and a nuclear family study. The frequency of MICA5 was significantly increased in the T1D patient grou...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.032
更新日期:2006-01-01 00:00:00
abstract::We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90086-5
更新日期:1990-04-01 00:00:00
abstract::There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(88)90087-0
更新日期:1988-02-01 00:00:00
abstract::PCR-based analyses were performed for the identification of HLA-B44 subgroups. Genomic DNA from six homozygous cell lines and 44 healthy individuals who had serologically tested positive for HLA-B44 was investigated for polymorphism in exons 2 and 3 of the HLA-B44 genes. Two primers were designed for specific amplific...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00071-w
更新日期:1995-01-01 00:00:00
abstract::Polymorphisms of interleukin-23 receptor (IL23R) gene have recently been reported to be associated with the susceptibility to several immune-related diseases. The aim of this study was to determine the association of IL23R polymorphisms with Vogt-Koyanagi-Harada (VKH) syndrome, a disease presumably mediated by autoimm...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.026
更新日期:2010-04-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90067-0
更新日期:1989-05-01 00:00:00
abstract::Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.011
更新日期:2016-06-01 00:00:00
abstract::We compared the immunohistochemical reaction patterns of HLA-G-specific antibodies 87G, 4H84, G233, 16G1, and BFL.1 on human placentas under three different preparative conditions and on cryosections of other human tissues. Human and murine cell lines, either naturally expressing or transfected with HLA-G, were analyz...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00207-x
更新日期:2000-11-01 00:00:00
abstract::The occurrence of graft rejection episodes after orthotopic liver transplantation (OLT) despite the use of immunosuppressive drugs designed to suppress T lymphocyte functions, indicates the involvement of other types of cells in this process. The activity of natural killer cells and their killer immunoglobulin-like re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.10.016
更新日期:2005-11-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.02.010
更新日期:2010-06-01 00:00:00