当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Antigen-specific T cell clones restricted by DR, DRw53 (MT), or DP (SB) Class II HLA molecules. Inhibition studies with monoclonal HLA-specific antibodies.

Antigen-specific T cell clones restricted by DR, DRw53 (MT), or DP (SB) Class II HLA molecules. Inhibition studies with monoclonal HLA-specific antibodies.

Abstract：

:T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presenting cells (APC). The restriction pattern of two TLCs, however, closely followed the DRw53 specificity, while one TLC seemed to be restricted by elements on DPw4 molecules. A panel of murine monoclonal antibodies (Mabs) was employed to further dissect the restriction specificities. The proliferative capacity of some of the TLCs was studied with and without Mabs directed against different HLA molecules, using non-T cells, monocytes, and peripheral blood dendritic cells as APC. Two Mabs, 7.2 and D-54, which seem to detect monomorphic determinants on HLA-DR, inhibited both DR- and DRw53-restricted TLCs. One Mab, 109d6 which reacts with DRw53 determinants, selectively inhibited the DRw53-restricted TLCs. The DP-restricted TLC was not inhibited significantly by any tested Mabs, including two Mabs with putative specificity for monomorphic determinants on the DP molecule.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Qvigstad E,Gaudernack G,Thorsby E

doi

10.1016/0198-8859(84)90060-0

subject

Has Abstract

pub_date

1984-12-01 00:00:00

pages

207-17

issue

4

eissn

0198-8859

issn

1879-1166

pii

0198-8859(84)90060-0

journal_volume

11

pub_type

杂志文章

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