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Leukocyte density and composition in human cycling endometrium with uterine fibroids.

Abstract：

:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunostained for the leukocyte common and subset-specific antigens. The immunoreactive cells in the unit areas were enumerated under a light microscope. The stromal pan-leukocyte density in the proliferative phase was significantly higher in the endometrium in the NN group than in the non-NN group. The macrophage density was higher in the NN group than in the non-NN group throughout the menstrual cycle. The NK cell density in the mid-to-late secretory phase was lower in the NN group than in the non-NN group. The T cell density in the midsecretory phase was higher in the non-NN group than in the non-UF group. The neutrophil density in the proliferative phase was higher in the non-NN group than in the non-UF group. The leukocyte density and composition in the endometrium with UF are different from those without UF, suggesting their local effects on endometrial leukocyte population.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Kitaya K,Yasuo T

doi

10.1016/j.humimm.2009.11.014

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

158-63

issue

2

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(09)00654-5

journal_volume

71

pub_type

杂志文章

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