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TCR repertoire of suppressor CD8+CD28- T cell populations.

Abstract：

:The cellular basis of graft rejection and the development of strategies for specific suppression of T cell responses against allogeneic and xenogeneic transplants represents an area of active investigation. Recently, a population of MHC-class I restricted CD8+CD28- T suppressor cells (Ts) which are able to inhibit specifically the proliferative response of allospecific, xenospecific and nominal-antigen specific CD4+ T helper cells (Th) has been identified. We have studied the TCR V beta gene repertoire expressed by CD8+CD28- Ts isolated from allospecific, xenospecific, and nominal antigen-specific T cell lines (TCL). A limited V beta repertoire has been found in all TCLs studied. The most restricted TCR V beta usage was observed within the population of Ts from xenospecific TCLs. The TCR V beta usage within the Ts subset of TCL differs from the TCR repertoire expressed by the CD4+ Th subset of the same TCL. This is consistent with the fact that Ts and Th cells recognize distinct MHC/ antigen complexes. The finding that the TCR repertoire used by Ts is limited opens new avenues for studying the mechanisms of transplant rejection.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Pennesi G,Liu Z,Ciubotariu R,Jiang S,Colovai A,Cortesini R,Suciu-Foca N,Harris P

doi

10.1016/s0198-8859(98)00134-7

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

291-304

issue

4

eissn

0198-8859

issn

1879-1166

pii

S0198885998001347

journal_volume

60

pub_type

杂志文章

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