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CD4(+)CD25(high)CD127(low) regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation.

Abstract：

:Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) with sirolimus (rapamycin)-eluting stents (SES; n = 43). The relation between initial Treg values and the severity of coronary atherosclerosis was observed. Treg and sCD25 levels were increased 1 month after CS versus baseline values and versus data in the control group (coronary angiography [CA], n = 20). A positive correlation between Treg and sCD25 levels was reported, whereas no relation was observed with the length of SES implanted. HsCRP level was increased during the first 7 days and returned to baseline values 1 month after CS/CA. Treg content is lower in patients with multivessel CAD. Elevated levels of Tregs and sCD25 after SES implantation might occur because of the immunomodulating effect of rapamycin.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Potekhina AV,Provatorov SI,Sokolov VO,Pylaeva EA,Masenko VP,Noeva EA,Kukhtina NB,Krasnikova TL,Arefieva TI

doi

10.1016/j.humimm.2011.03.015

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

553-7

issue

7

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(11)00068-1

journal_volume

72

pub_type

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