当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A.

Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A.

Abstract：

:It has been extensively documented the role of the indirect pathway of allorecognition in allograft rejection. However, recent data demonstrate that the manipulation of this pathway could be also sufficient to promote prolongation of allograft survival. In the present study we evaluated the effect of preoperative immunization with the WF-specific MHC class II peptides RT1.D2 and RT1.B2 in combination with low-dose CsA from days 0 to 7 (5 mg/kg/day) and from days 8 to 30 (1 mg/kg/day) after WF small bowel transplantation. Seven days before and on the day of transplantation, LEW recipients were immunized with the two WF MHC class II peptides RT1.B2 and RT1.D2. The CsA monotherapy induced an allograft survival of 49.3 +/- 6.1 days. MHC class II peptide immunization had a limited effect on allograft survival for RT1.D2 (47.1 +/- 3.8 days) and induced prolongation of allograft survival for RT1.B2 (73.6 +/- 34.6 days). This effect seems to be based on the absence or silence of RT1.B2-reactive T cells and rejection seems to be correlated with the presence of RT1.B2-specific T cells in the late phase. Therefore, the combination of RT1.B2 with low-dose CsA shifts the immunological response and protects small bowel allograft rejection.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Otto C,Gasser M,Waaga-Gasser AM,Rohde AC,Lenhard M,Jost S,Gassel HJ,Ulrichs K,Timmermann W

doi

10.1016/s0198-8859(02)00451-2

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

880-7

issue

10

eissn

0198-8859

issn

1879-1166

pii

S0198885902004512

journal_volume

63

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Definition of IDDM-associated HLA DQ and DX RFLPs by segregation analysis of multiplex sibships.

    abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90046-3

    authors： Carrier CM,Mollen N,Rothman WC,Rodriguez de Cordoba S,Rey-Campos J,Ginsberg-Fellner F,Carpenter C,Rubinstein P

    更新日期：1989-01-01 00:00:00

  • Monoclonal antibodies specific for human polymorphic cell surface antigens. I. Evaluation of methodologies. Report on a workshop.

    abstract：:Five techniques, the direct and the antiglobulin enhanced cytotoxicity assays, indirect immunofluorescence, the enzyme-linked immunosorbent assay, and the radioimmunoassay, were evaluated in a workshop to determine their utility in studies of the interactions of monoclonal antibodies with HLA antigens expressed on lym...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(82)90016-7

    authors： Krakauer H,Hartzman RJ,Johnson AH

    更新日期：1982-04-01 00:00:00

  • T-cell responses against products of oncogenes: generation and characterization of human T-cell clones specific for p21 ras-derived synthetic peptides.

    abstract：:Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(92)90334-j

    authors： Gedde-Dahl T 3rd,Eriksen JA,Thorsby E,Gaudernack G

    更新日期：1992-04-01 00:00:00

  • Role of galectin-3 in the pathogenesis of bladder transitional cell carcinoma.

    abstract：:Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in ver...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2015.09.036

    authors： Zeinali M,Adelinik A,Papian S,Khorramdelazad H,Abedinzadeh M

    更新日期：2015-10-01 00:00:00

  • Maternal antigen presenting cells are a source of plasmatic HLA-G during pregnancy: longitudinal study during pregnancy.

    abstract：:The aim of this work was to investigate the longitudinal evolution of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G. Blood samples were obtained from 45 volunteers during normal pregnancy, 8 of them monthl...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.04.007

    authors： Alegre E,Díaz-Lagares A,Lemaoult J,López-Moratalla N,Carosella ED,González A

    更新日期：2007-08-01 00:00:00

  • Balanced polymorphism in bottlenecked populations: the case of the CCR5 5' cis-regulatory region in Amazonian Amerindians.

    abstract：:The 5' cis-regulatory region of the CCR5 gene exhibits a strong signature of balancing selection in several human populations. Here we analyze the polymorphism of this region in Amerindians from Amazonia, who have a complex demographic history, including recent bottlenecks that are known to reduce genetic variability....

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.05.022

    authors： Ramalho RF,Santos EJ,Guerreiro JF,Meyer D

    更新日期：2010-09-01 00:00:00

  • Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species in Nicotiana benthamiana.

    abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.01.002

    authors： Li C,Jiang Y,Guo W,Liu Z

    更新日期：2013-05-01 00:00:00

  • Real-time PCR using fluorescent resonance emission transfer probes for HLA-B typing.

    abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.02.038

    authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

    更新日期：2006-04-01 00:00:00

  • HLA and complement factors alleles sharing in Italian couples with recurrent spontaneous abortions.

    abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00028-7

    authors： Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

    更新日期：1998-06-01 00:00:00

  • Rapid evaluation of soluble HLA-G levels in supernatants of in vitro fertilized embryos.

    abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.11.003

    authors： Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

    更新日期：2007-04-01 00:00:00

  • Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-alpha and ribavirin treatment for chronic hepatitis C virus infection.

    abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(03)00041-7

    authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

    更新日期：2003-05-01 00:00:00

  • Serological, functional, and immunochemical characterization of a monoclonal antibody (MoAb Q2/70) to human Ia-like antigens.

    abstract：:Serological and immunochemical studies showed that monoclonal antibody Q2/70 (MoAb Q2/70), produced by the hybridoma technique, is specific for human Ia-like antigens. This antibody recognizes an antigenic determinant which is different from those defining the serologic polymorphism of Ia-like antigens, and is express...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90016-6

    authors： Quaranta V,Indiveri F,Glassy MC,Ng A,Russo C,Molinaro GA,Pellegrino MA,Ferrone S

    更新日期：1980-10-01 00:00:00

  • Increased T cell immunosenescence and accelerated maturation phenotypes in older kidney transplant recipients.

    abstract：:Older kidney transplant recipients experience increased rates of infection and death, and less rejection, compared with younger patients. However, little is known about immune dysfunction in older compared with younger kidney transplant recipients and whether it is associated with infection. We evaluated T cell phenot...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.06.006

    authors： Schaenman JM,Rossetti M,Sidwell T,Groysberg V,Sunga G,Korin Y,Liang E,Zhou X,Abdalla B,Lum E,Bunnapradist S,Pham T,Danovitch G,Reed EF

    更新日期：2018-09-01 00:00:00

  • Orientation of HLA-DNA gene and identification of a CpG island-associated gene adjacent to DNA in human major histocompatibility complex class II region.

    abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90059-i

    authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

    更新日期：1991-11-01 00:00:00

  • The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells.

    abstract：:The expression pattern of several genes associated with different processes in melanocytes, including melanogenesis, is changed in vitiligo patients. We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), a...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.01.011

    authors： Reimann E,Kingo K,Karelson M,Reemann P,Loite U,Sulakatko H,Keermann M,Raud K,Abram K,Vasar E,Silm H,Kõks S

    更新日期：2012-04-01 00:00:00

  • Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma.

    abstract：:The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, TIM-1, was considered as a membrane protein that is associated with the development of helper T cell (Th2) biased immune responses, and may be selectively expressed on Th2 cells....

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.09.011

    authors： Chae SC,Song JH,Heo JC,Lee YC,Kim JW,Chung HT

    更新日期：2003-12-01 00:00:00

  • IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells.

    abstract：:Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate hum...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.06.002

    authors： Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

    更新日期：2018-08-01 00:00:00

  • 14-Base pair polymorphism of human leukocyte antigen-G as genetic determinant in heart transplantation and cyclosporine therapy monitoring.

    abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.07.012

    authors： Torres MI,Luque J,Lorite P,Isla-Tejera B,Palomeque T,Aumente MD,Arizon J,Peña J

    更新日期：2009-10-01 00:00:00

  • T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients.

    abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.05.008

    authors： Ma X,Zha J,He J,Chen L,Huang J,Wu W,Tian P,Qian BH,Yu L,Jiang Y,Xu B

    更新日期：2020-08-01 00:00:00

  • DRB1*03 diversity and DRB3 associations in five major population groups in the United States.

    abstract：:One hundred sixty-one DRB1*03 positive individuals from each of five U.S. population groups (Caucasoids, African Americans, Asians/Pacific Islanders, Hispanics, and Native Americans) were randomly selected from a database of 82,979 individuals. DRB1*03 alleles were identified by polymerase chain reaction-sequence-spec...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00379-2

    authors： Tang TF,Wang J,Slack R,Lin YS,Li L,Heine U,Ng J,Hartzman RJ,Katovich Hurley C

    更新日期：2002-03-01 00:00:00

  • Elevated pretransplantation soluble CD30 is associated with decreased early allograft function after human lung transplantation.

    abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.12.005

    authors： Shah AS,Leffell MS,Lucas D,Zachary AA

    更新日期：2009-02-01 00:00:00

  • Alleles and genotypes of polymorphisms of IL-18, TNF-α and IFN-γ are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil.

    abstract：:Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.04.029

    authors： Teixeira AC,Mendes CT Jr,Marano LA,Deghaide NH,Secaf M,Elias J Jr,Muglia V,Donadi EA,Martinelli AL

    更新日期：2013-08-01 00:00:00

  • Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.

    abstract：:Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymp...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.01.011

    authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Kotilainen P,Pelliniemi TT,Nikoskelainen J,Lilius EM

    更新日期：2013-05-01 00:00:00

  • Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals.

    abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(96)00080-8

    authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

    更新日期：1996-06-01 00:00:00

  • Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation.

    abstract：:Even when kidney allografts are well matched for human leukocyte antigen (HLA) and anti-HLA antibodies are not detected, graft rejection can still occur. There is evidence that some patients who lose their graft have antibodies specific for major histocompatibility complex (MHC) class I-related chain A (MICA) antigens...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.05.004

    authors： Cox ST,Stephens HA,Fernando R,Karasu A,Harber M,Howie AJ,Powis S,Zou Y,Stastny P,Madrigal JA,Little AM

    更新日期：2011-10-01 00:00:00

  • Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient.

    abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00401-9

    authors： Knutson KL,Disis ML

    更新日期：2002-07-01 00:00:00

  • Matrix metalloproteinase-9 promoter polymorphisms in Korean patients with systemic lupus erythematosus.

    abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.03.005

    authors： Lee YJ,Woo M,Nam JH,Baek J,Im CH,Lee EY,Lee EB,Park KS,Song YW

    更新日期：2008-06-01 00:00:00

  • The clinician's guide to the anti-vaccinationists' galaxy.

    abstract：:In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...

    journal_title：Human immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.humimm.2012.03.014

    authors： Poland GA,Jacobson RM

    更新日期：2012-08-01 00:00:00

  • Detection of HLA restricted anti-minor histocompatibility antigen(s) reactive cells from skin GVHD lesions.

    abstract：:Recipients of marrow grafts from HLA-identical, (including MLC non-reactive) sibling donors have a 40-50% incidence of acute graft vs. host disease (GVHD); the involvement of non-HLA linked, minor histocompatibility antigens (miHA) has been implicated. One of the target tissues of GVHD is the skin where morphological ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(84)90064-8

    authors： Reinsmoen NL,Kersey JH,Bach FH

    更新日期：1984-12-01 00:00:00

  • Characterization of HLA class I specific antibodies by ELISA using solubilized antigen targets: I. Evaluation of the GTI QuikID assay and analysis of antibody patterns.

    abstract：:The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00254-8

    authors： Zachary AA,Delaney NL,Lucas DP,Leffell MS

    更新日期：2001-03-01 00:00:00