当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City.

Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City.

Abstract：

:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 11 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (63.85 ± 1.55% by ML; 57.19% of Native American haplotypes) and European (28.53 ± 3.13% by ML; 28.40% of European haplotypes), and a less apparent African genetic component (7.61 ± 1.96% by ML; 7.17% of African haplotypes).

journal_name

Hum Immunol

journal_title

Human immunology

authors

Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Bravo-Acevedo A,Juárez-Nicolás F,Arriaga-Perea AJ,Vega-Martínez MDR,Ortega-Yáñez A,Benítez-Arvizu G,Arrieta-Bolaños E,Clayton S,Juárez-Cortés ED,López-Gil C,García-Álvarez R

doi

10.1016/j.humimm.2019.07.297

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

539-543

issue

9

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(19)30961-9

journal_volume

81

pub_type

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