Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells.

abstract：:Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...

journal_title：Human immunology

authors： Heinold A,Kuehl B,Brenner-Weiss G,Opelz G,Tran TH

更新日期：2010-05-01 00:00:00

abstract：:The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies...

journal_title：Human immunology

authors： Halfpenny IA,Middleton D,Barnett YA,Williams F

更新日期：2004-06-01 00:00:00

abstract：:The compatibility of HLA-A,-B expression between mother and offspring was examined in 410 families serologically tissue typed within a single transplant lab from 1972 thru 1982. The study group included 410 mothers of 1719 children (range 2-13/mother), with 352 one-father and 58 multiple-father families There were sev...

journal_title：Human immunology

authors： MacQueen JM,Sanfilippo FP

更新日期：1984-11-01 00:00:00

abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...

journal_title：Human immunology

authors： Hackstein H,Hofmann H,Bohnert A,Bein G

更新日期：1999-11-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection has been associated with enhanced expression of HLA antigens on the endothelium and with cellular infiltrates within the graft following human organ transplantation. We investigated the interactions between human cytomegalovirus-infected cultured endothelial cells and cocultured ...

journal_title：Human immunology

authors： Scholz M,Blaheta RA,Cinatl J,Encke A,Doerr HW,Markus BH

更新日期：1995-11-01 00:00:00

abstract：:It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...

journal_title：Human immunology

authors： Speletas M,Kalala F,Mitroulis I,Papadopoulos V,Merentiti V,Germenis AE,Ritis K

更新日期：2009-09-01 00:00:00

abstract：:We describe the production of mouse monoclonal antibodies specific for the human TcR using as the immunogen transfected murine T-cell hybridoma cells coexpressing mouse CD3 with human Jurkat TcR alpha and beta chains. The shortage of monoclonal antibodies (mAbs) specific for the human TcR-V alpha and V beta families r...

journal_title：Human immunology

authors： Zumla A,McCormack A,George A,Batchelor R,Lechler R

更新日期：1992-11-01 00:00:00

abstract：:HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immu...

journal_title：Human immunology

authors： Jacquier A,Dumont C,Carosella ED,Rouas-Freiss N,LeMaoult J

更新日期：2020-04-01 00:00:00

abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

journal_title：Human immunology

authors： Jackson DG,Capra JD

更新日期：1995-05-01 00:00:00

abstract：:Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage o...

journal_title：Human immunology

authors： Balla-Jhagjhoorsingh SS,Verschoor EJ,de Groot N,Teeuwsen VJ,Bontrop RE,Heeney JL

更新日期：2003-07-01 00:00:00

abstract：:Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine th...

journal_title：Human immunology

authors： Gu D,Chen Z,Zhao H,Du W,Xue F,Ge J,Sui T,Wu H,Liu B,Lu S,Zhang L,Yang R

更新日期：2010-06-01 00:00:00

abstract：:HLA-DQA1 typing of the 4AOHW cell panel is presented using a novel strategy that exploits both intron and exon polymorphisms. Intron sequences adjacent to the variable HLA-DQA1 second exon exhibit stable polymorphisms that are specific for locus alleles and certain suballelic DR/DQ haplotypes. A PCR-RFLP method has be...

journal_title：Human immunology

authors： Limm TM,Ashdown ML,Naughton MJ,McGinnis MD,Simons MJ

更新日期：1993-09-01 00:00:00

abstract：:Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

journal_title：Human immunology

authors： Zheng J,Yin J,Huang R,Petersen F,Yu X

更新日期：2013-08-01 00:00:00

abstract：:The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...

journal_title：Human immunology

authors： Acton RT,Dasanayake AP,Harrison RA,Li Y,Roseman JM,Go RC,Wiener H,Caufield PW

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migration and cytokine release in the CNS, and it was demonstrated to strongly contribute to CNS inflamma...

journal_title：Human immunology

authors： Troncoso LL,Pontillo A,Oliveira EML,Finkelszteijn A,Schneider S,Chies JAB

更新日期：2018-08-01 00:00:00

abstract：:In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

journal_title：Human immunology

authors： Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

更新日期：1989-12-01 00:00:00

abstract：:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...

journal_title：Human immunology

authors： Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

更新日期：1995-10-01 00:00:00

abstract：:HLA exhibits the most extensive polymorphism of any of the known human genes and is known as a genetic marker which allows genetic background of many diseases and physical phenomena. In this study, we, therefore, tried to investigate the regulation of HLA polymorphism and peak bone mass (PBM) in order to elucidate the...

journal_title：Human immunology

authors： Tsuji S,Munkhbat B,Hagihara M,Tsuritani I,Abe H,Tsuji K

更新日期：1998-04-01 00:00:00

abstract：:The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune mo...

journal_title：Human immunology

authors： Persson G,Jørgensen N,Nilsson LL,Andersen LHJ,Hviid TVF

更新日期：2020-04-01 00:00:00

abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...

journal_title：Human immunology

authors： Hurley CK,Fernandez-Vina M,Hildebrand WH,Noreen HJ,Trachtenberg E,Williams TM,Baxter-Lowe LA,Begovich AB,Petersdorf E,Selvakumar A,Stastny P,Hegland J,Hartzman RJ,Carston M,Gandham S,Kollman C,Nelson G,Spellman S,Sett

更新日期：2007-01-01 00:00:00

abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

journal_title：Human immunology

authors： Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

更新日期：2017-02-01 00:00:00

abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...

journal_title：Human immunology

authors： Torres MI,Luque J,Lorite P,Isla-Tejera B,Palomeque T,Aumente MD,Arizon J,Peña J

更新日期：2009-10-01 00:00:00

abstract：:RING 11, a second transport-associated gene (TAP2), has been recently identified in the DR-DP interval of the human class II region. Two predominant alleles, TAP2A and TAP2B, differing by 17 amino acids at the C-terminus of the ATP-binding domain are present in the Caucasoid population at frequencies of 79% and 21%, r...

journal_title：Human immunology

authors： Eiermann TH,Fakler J,Goldmann SF,Böhm BO

更新日期：1993-11-01 00:00:00

abstract：:This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...

journal_title：Human immunology

authors： Lindemann M,Dioury Y,Beckebaum S,Cicinnati VR,Gerken G,Broelsch CE,Wrighton-Smith P,Grosse-Wilde H

更新日期：2009-01-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...

journal_title：Human immunology

authors： Mickelson EM,Petersdorf E,Anasetti C,Martin P,Woolfrey A,Hansen JA

更新日期：2000-02-01 00:00:00

abstract：:To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...

journal_title：Human immunology

authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Laitinen I,Kotilainen P,Rajamäki A,Nikoskelainen J,Lilius EM

更新日期：2009-04-01 00:00:00

abstract：:Detection and avoidance of donor-reactive antibodies in the sera of potential organ transplant recipients is key to a successful transplant outcome. Techniques of antibody detection that use flow cytometry are more sensitive than those that rely upon a visual determination of cytotoxicity. However, as conventionally p...

journal_title：Human immunology

authors： Wetzsteon PJ,Head MA,Fletcher LM,Lye WC,Norman DJ

更新日期：1992-10-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:Minor lymphocyte stimulating locus (Mls) gene products in association with mouse major histocompatibility complex (MHC) class II molecules are known to determine the repertoire of T-cell receptor (TCR) in mature T cells. In order to test whether human class II molecules can present mouse Mls, HLA-DQ beta transgenic mi...

journal_title：Human immunology

authors： Zhou P,Anderson GD,Savarirayan S,Inoko H,David CS

更新日期：1991-05-01 00:00:00