当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Innate immune receptors in solid organ transplantation.

Innate immune receptors in solid organ transplantation.

Abstract：

:The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better strategies to fight off infectious diseases and/or to prevent their occurrence. However, infected individuals are for most part outliers in a given population and therefore, the primary function of these receptors should be considered in pathogen-free conditions. Our current understanding indicates that an important physiological function of PRRs resides in their capacity to maintain epithelial homeostasis in response to colonizing commensals. In addition, endogenous host-derived ligands, expressed under stressed, albeit sterile, conditions (called DAMPs for Danger-Associated Molecular Patterns) are also able to trigger PRR signaling. Solid organ transplantation represents a unique situation where both contributions of PRRs signaling can be studied. Indeed, dysbiosis (either caused by antibiotherapy preceding organ transplantation or simply due to the microbiota differences between the transplanted organ and the recipient host) is a characteristic feature of this situation, which is also marked by a massive synthesis and liberation of DAMPs as a result of hypoxia/reperfusion injury. Therefore, in the transplanted organ, at least two compartments (epithelial and that composed of immune cells) participate in graft rejection/acceptance depending on the activation status of expressed PRRs.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Georgel P

doi

10.1016/j.humimm.2016.04.004

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1071-1075

issue

11

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(16)30044-1

journal_volume

77

pub_type

杂志文章,评审

相关文献

HUMAN IMMUNOLOGY文献大全
  • CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis.

    abstract：OBJECTIVE:The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD). METHODS:The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G ...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2014.02.020

    authors： Lee YH,Kim JH,Seo YH,Choi SJ,Ji JD,Song GG

    更新日期：2014-05-01 00:00:00

  • CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.

    abstract：:Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.02.001

    authors： Sinha S,Jha GN,Anand P,Qidwai T,Pati SS,Mohanty S,Mishra SK,Tyagi PK,Sharma SK,Venkatesh V,Habib S

    更新日期：2009-04-01 00:00:00

  • Effect of phorbol ester and calcium ionophore on human thymocytes.

    abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00276-2

    authors： Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

    更新日期：2001-08-01 00:00:00

  • Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-alpha and ribavirin treatment for chronic hepatitis C virus infection.

    abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(03)00041-7

    authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

    更新日期：2003-05-01 00:00:00

  • Interleukin-6 gene variants and the risk of sepsis development in children.

    abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.06.003

    authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

    更新日期：2007-09-01 00:00:00

  • HLA-G(∗)01:05N null allele in Mayans (Guatemala) and Uros (Titikaka Lake, Peru): evolution and population genetics.

    abstract：:HLA-G molecules seem to have a protective effect for the semi-allogeneic fetus by mother immunosuppression. Also, pregnancy pathologies have been associated to HLA-G(∗)01:05N "null allele". In addition, other general regulatory immune functions have been associated to HLA-G in infections, tumors and autoimmunity. Thus...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.12.013

    authors： Arnaiz-Villena A,Enriquez-de-Salamanca M,Areces C,Alonso-Rubio J,Abd-El-Fatah-Khalil S,Fernandez-Honrado M,Rey D

    更新日期：2013-04-01 00:00:00

  • Sequential analysis by immunoprecipitation-MALDI-TOF: a novel method for detection and identification of alloantibody specificities.

    abstract：:Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.02.006

    authors： Heinold A,Kuehl B,Brenner-Weiss G,Opelz G,Tran TH

    更新日期：2010-05-01 00:00:00

  • Attenuated expression of interferon-β and interferon-λ1 by human alternatively activated macrophages.

    abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.267

    authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

    更新日期：2013-12-01 00:00:00

  • Alloreactive lymphoid infiltrates in human heart transplants. Loss of class II-directed cytotoxicity more than 3 months after transplantation.

    abstract：:From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90071-g

    authors： Ouwehand AJ,Vaessen LM,Baan CC,Jutte NH,Balk AH,Essed CE,Bos E,Claas FH,Weimar W

    更新日期：1991-01-01 00:00:00

  • Identification of the amino acid residues contributing to monoclonal antibody-defined DQw1 epitopes.

    abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90009-x

    authors： Nordwig H,Kwok WW,Johnson JP

    更新日期：1991-06-01 00:00:00

  • Detection of HLA restricted anti-minor histocompatibility antigen(s) reactive cells from skin GVHD lesions.

    abstract：:Recipients of marrow grafts from HLA-identical, (including MLC non-reactive) sibling donors have a 40-50% incidence of acute graft vs. host disease (GVHD); the involvement of non-HLA linked, minor histocompatibility antigens (miHA) has been implicated. One of the target tissues of GVHD is the skin where morphological ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(84)90064-8

    authors： Reinsmoen NL,Kersey JH,Bach FH

    更新日期：1984-12-01 00:00:00

  • Matrix metalloproteinase-9 promoter polymorphisms in Korean patients with systemic lupus erythematosus.

    abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.03.005

    authors： Lee YJ,Woo M,Nam JH,Baek J,Im CH,Lee EY,Lee EB,Park KS,Song YW

    更新日期：2008-06-01 00:00:00

  • Associations of MHC genes with levels of caries-inducing organisms and caries severity in African-American women.

    abstract：:The aim of this investigation was to evaluate the relationship between MHC alleles at the HLA-DRB1, DQB1 and TNFa microsatellite loci and levels of oral bacteria that play a role in the etiology of dental caries, and the DMFS index in 186 AA primparous women. The average age of the cohort was 20.8+/-3.7 years. The med...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00088-9

    authors： Acton RT,Dasanayake AP,Harrison RA,Li Y,Roseman JM,Go RC,Wiener H,Caufield PW

    更新日期：1999-10-01 00:00:00

  • The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18.

    abstract：:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90038-4

    authors： Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

    更新日期：1989-11-01 00:00:00

  • Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation.

    abstract：:Even when kidney allografts are well matched for human leukocyte antigen (HLA) and anti-HLA antibodies are not detected, graft rejection can still occur. There is evidence that some patients who lose their graft have antibodies specific for major histocompatibility complex (MHC) class I-related chain A (MICA) antigens...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.05.004

    authors： Cox ST,Stephens HA,Fernando R,Karasu A,Harber M,Howie AJ,Powis S,Zou Y,Stastny P,Madrigal JA,Little AM

    更新日期：2011-10-01 00:00:00

  • Assignment of HLA-DPB alleles by computerized matching based upon sequence data.

    abstract：:Routine HLA typing by serology has been supported by DNA or protein analysis of the respective molecules in cases when serologic typing was inconclusive or difficult to perform. DNA analysis by RFLP, SSO, or PCR amplification with SSP is a reliable tool for the identification of alleles. Because DNA sequences may now ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(93)90503-s

    authors： Rozemuller EH,Bouwens AG,Bast BE,Tilanus MG

    更新日期：1993-08-01 00:00:00

  • Cytometry-based analysis of HLA-G functions according to ILT2 expression.

    abstract：:HLA-G was described as a molecule inhibiting NK and T cells functions through its receptor, ILT2. However, most functional studies of HLA-G were so far performed on heterogeneous immune populations and regardless of ILT2 expression. This may lead to an underestimation of the effect of HLA-G. Thus, considering the immu...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.02.001

    authors： Jacquier A,Dumont C,Carosella ED,Rouas-Freiss N,LeMaoult J

    更新日期：2020-04-01 00:00:00

  • HLA class I polymorphism: structure and function and still questions.

    abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00175-4

    authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

    更新日期：1997-09-15 00:00:00

  • Potential influence of interleukin-1 haplotype IL-1 beta-511*T-IL-1RN*1 in conferring low risk to middle third location of esophageal cancer: a case-control study.

    abstract：:Interleukin (IL)-1 gene polymorphisms affect several inflammatory diseases, including cancer. Therefore, we studied genetic association of biallelic (-511C>T) polymorphism of IL-1 beta and 86-bp VNTR polymorphism of IL-1RN in 159 patients with esophageal cancer (EC) and 194 age- and gender-matched healthy controls. Ge...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2008.01.012

    authors： Upadhyay R,Jain M,Kumar S,Ghoshal UC,Mittal B

    更新日期：2008-03-01 00:00:00

  • Isoforms of human leukocyte antigen-G and their inhibitory receptors in human kidney allograft acceptance.

    abstract：:Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.07.023

    authors： Wu J,Zhang W,Hernandez-Lopez P,Fabelo E,Parikh M,Mulloy LL,Horuzsko A

    更新日期：2009-12-01 00:00:00

  • Simultaneous HLA Class I and Class II antibodies screening with flow cytometry.

    abstract：:A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class I and 30 different Class II microbeads coated with purified HLA antigens. The antibodies in the serum that react specifically to the coated HLA antigens ar...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00020-2

    authors： Pei R,Wang G,Tarsitani C,Rojo S,Chen T,Takemura S,Liu A,Lee J

    更新日期：1998-05-01 00:00:00

  • Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A.

    abstract：:It has been extensively documented the role of the indirect pathway of allorecognition in allograft rejection. However, recent data demonstrate that the manipulation of this pathway could be also sufficient to promote prolongation of allograft survival. In the present study we evaluated the effect of preoperative immu...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00451-2

    authors： Otto C,Gasser M,Waaga-Gasser AM,Rohde AC,Lenhard M,Jost S,Gassel HJ,Ulrichs K,Timmermann W

    更新日期：2002-10-01 00:00:00

  • Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.

    abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.09.003

    authors： Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

    更新日期：2007-11-01 00:00:00

  • B cells in chronic graft-versus-host disease.

    abstract：:Allogeneic hematopoietic stem cell transplantation (alloHCT) is the definitive therapy for numerous otherwise incurable hematologic malignancies and non-malignant diseases. The genetic disparity between donor and recipient both underpins therapeutic effects and confers donor immune system-mediated damage in the recipi...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2019.03.003

    authors： McManigle W,Youssef A,Sarantopoulos S

    更新日期：2019-06-01 00:00:00

  • Association between human leukocyte antigen class I and II alleles and hepatitis C virus infection in high-risk hemodialysis patients awaiting kidney transplantation.

    abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.008

    authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

    更新日期：2013-12-01 00:00:00

  • TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1.

    abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)00124-9

    authors： Jackson DG,Capra JD

    更新日期：1995-05-01 00:00:00

  • Physicochemical and immunological studies on 4-hydroxynonenal modified HSA: implications of protein damage by lipid peroxidation products in the etiopathogenesis of SLE.

    abstract：:4-Hydroxynonenal (HNE) is the most abundant and toxic aldehyde generated by the oxidation of plasma membrane polyunsaturated fatty acids. Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is primarily characterized by increased levels of autoantibodies, predominantly against ds-DNA. However, the initia...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.08.011

    authors： Khatoon F,Moinuddin,Alam K,Ali A

    更新日期：2012-11-01 00:00:00

  • Inverse association of peripheral blood CD4(+) invariant natural killer T cells with atopy in human asthma.

    abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.10.011

    authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

    更新日期：2010-02-01 00:00:00

  • Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expressi

    abstract：:Mutant human B-lymphoblastoid cell lines, 721.174 and 721.180, that have greatly reduced expressions of known class I and class II HLA antigens were produced by two cycles of gamma-ray mutagenesis followed by selection for HLA antigen loss. Residual binding of monoclonal antibodies directed against class II antigens w...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/0198-8859(84)90047-8

    authors： DeMars R,Chang CC,Shaw S,Reitnauer PJ,Sondel PM

    更新日期：1984-10-01 00:00:00

  • Establishment and application of a novel T cell clonality analysis using single-strand conformation polymorphism of T cell receptor messenger signals.

    abstract：:To identify the existence of antigen specific T cell responses and to follow the changes of these reactions, it is considered useful to evaluate whether certain T cells clonally accumulate in the lymphocyte population. For this purpose, we have established a novel method to analyze T cell clonality using a combination...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(96)00080-8

    authors： Yamamoto K,Masuko-Hongo K,Tanaka A,Kurokawa M,Hoeger T,Nishioka K,Kato T

    更新日期：1996-06-01 00:00:00