Abstract:
:Using a large battery of Bw16, w38, and w39 antisera, a new variant of Bw16 has been identified in four unrelated Mexican-American families. The serologic pattern obtained is distinct from that for Bw38, Bw39, and 8W57 antigens. Absorption studies confirm the existence of this new Bw16 subtype which we term ST-16. ST-16 is Bw6-associated, with antigen frequency estimated to be 2.5% in Mexican-Americans.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Ness DB,Watson AK,Grumet FCdoi
10.1016/0198-8859(82)90050-7subject
Has Abstractpub_date
1982-02-01 00:00:00pages
55-62issue
1eissn
0198-8859issn
1879-1166pii
0198-8859(82)90050-7journal_volume
4pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Several risk factors including immune deficiencies, infections, and autoimmune diseases have been established for non-Hodgkin's lymphoma (NHL). For diffuse large B cell lymphoma (DLBCL), the most common type of lymphoma, no risk factors have been described, which may be due to the intrinsic heterogeneity of this disor...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.019
更新日期:2006-04-01 00:00:00
abstract::Population studies represent an integral part, and a necessary link in a complex chain of host-pathogen interactions, disease pathogenesis, and major histocompatibility complex polymorphism. HLA class I and class II allele and haplotype distributions among Venezuelan mestizos were determined. Genes of Mongoloid, Negro...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00088-8
更新日期:1997-06-01 00:00:00
abstract::To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00105-y
更新日期:1995-03-01 00:00:00
abstract:UNLABELLED:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate t...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.234
更新日期:2016-10-01 00:00:00
abstract::HLA-DQA1 typing of the 4AOHW cell panel is presented using a novel strategy that exploits both intron and exon polymorphisms. Intron sequences adjacent to the variable HLA-DQA1 second exon exhibit stable polymorphisms that are specific for locus alleles and certain suballelic DR/DQ haplotypes. A PCR-RFLP method has be...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90520-b
更新日期:1993-09-01 00:00:00
abstract::Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00276-2
更新日期:2001-08-01 00:00:00
abstract::CTLA-4 inhibitory molecule plays an important role in regulating T cell activation. It is considered a crucial element in keeping the immune balance and has been implicated in cancer, autoimmunity and transplantation immunology. Inconsistent observations are reported regarding its association with hematopoietic stem c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.08.002
更新日期:2013-12-01 00:00:00
abstract::The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00213-5
更新日期:2000-12-01 00:00:00
abstract::We have produced a monoclonal antibody detecting an HLA class II determinant absent from DR1,2,W6, and W10 (DQW1) homozygous B lymphoblastoid cell lines (BLCL). The antibody, SFR16-PI.2, immunoprecipitates molecules with electrophoretic mobilities of DQ (DS/DC) molecules from DR7 homozygous cell lines. SFR16-PI.2 bind...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90229-0
更新日期:1985-11-01 00:00:00
abstract::Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.06.001
更新日期:2019-10-01 00:00:00
abstract::Natural killer (NK) cells are key members of innate immunity against tumor and infection. Killer cell immunoglobulin-like receptor (KIR) genes regulates NK cell function, which varies substantially between individuals in the number and type. Specific KIRs are associated with certain diseases. Herein we investigated if...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.07.325
更新日期:2012-10-01 00:00:00
abstract::By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.08.279
更新日期:2008-11-01 00:00:00
abstract::Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a clonal level. However, the impact of a single virus on the allorepertoire has never been investigated at the polyclonal level. We made an inventory of the incidence and specificity of allo-HLA-cross-reactive-virus-specific CD8+ T...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.10.014
更新日期:2019-02-01 00:00:00
abstract::The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area has been limited, however, since CTL recognize minor alloantigens only in association with self-class I antigens. Thus, experiments designed to study minor all...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90035-8
更新日期:1987-05-01 00:00:00
abstract::The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.06.002
更新日期:2012-09-01 00:00:00
abstract::The polymorphic nature of the KIR3DL1/S1 gene complex has been investigated through the development of a polymerase chain reaction-sequence-specific oligonucleotide probes (PCR-SSOP) allele typing system. The KIR3DL1/S1 system was applied to a healthy group of Northern Irish individuals to establish allele frequencies...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.03.003
更新日期:2004-06-01 00:00:00
abstract::The expression of the Duffy Antigen/Receptor for Chemokines (DARC) on red blood cells (RBC) has been commonly determined using hemagglutination tests. Because the vast majority of African individuals are Duffy-negative, screening for DARC expression on RBC is a valuable tool to assess Caucasian admixture in population...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00039-7
更新日期:1999-08-01 00:00:00
abstract::The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(91)90009-x
更新日期:1991-06-01 00:00:00
abstract::Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.03.005
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). METHODS:A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA),...
journal_title:Human immunology
pub_type: 杂志文章,meta分析
doi:10.1016/j.humimm.2012.07.341
更新日期:2012-10-01 00:00:00
abstract::The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(96)00031-6
更新日期:1996-08-01 00:00:00
abstract::Vitamin D deficiency is adversely associated with diseases characterized by inflammation. The combination of the high incidence of vitamin D deficiency in patients undergoing allogeneic stem cell transplants (SCT) and the potential role of vitamin D deficiency in influencing graft-versus-host disease led us to further...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.04.019
更新日期:2012-07-01 00:00:00
abstract::The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90052-o
更新日期:1992-01-01 00:00:00
abstract::In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90017-5
更新日期:1985-06-01 00:00:00
abstract::The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(80)90005-1
更新日期:1980-07-01 00:00:00
abstract::Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.04.018
更新日期:2009-08-01 00:00:00
abstract::This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2008.07.018
更新日期:2008-11-01 00:00:00
abstract::Platelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(96)00019-5
更新日期:1996-04-01 00:00:00
abstract::Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.05.005
更新日期:2006-09-01 00:00:00
abstract::Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.01.002
更新日期:2013-05-01 00:00:00