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Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: a meta-analysis.

Abstract：

OBJECTIVE:The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). METHODS:A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). RESULTS:Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10(-6)), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10(-7)) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10(-8); OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10(-8), respectively). CONCLUSIONS:This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Song GG,Choi SJ,Ji JD,Lee YH

doi

10.1016/j.humimm.2012.07.341

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1055-9

issue

10

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(12)00506-X

journal_volume

73

pub_type

杂志文章,meta分析

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