Lymphocytes induce enhanced expression of HLA class I antigens on cytomegalovirus-infected syngeneic human endothelial cells.

abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

journal_title：Human immunology

authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

更新日期：2014-03-01 00:00:00

abstract：:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...

journal_title：Human immunology

authors： Delville M,Charreau B,Rabant M,Legendre C,Anglicheau D

更新日期：2016-11-01 00:00:00

abstract：:Presensitizing alloantibodies may represent a grave danger in organ transplantation, increasing the risk of antibody-mediated rejection (AMR) and graft loss. However, not all antibodies are harmful to the graft. In our study of a cohort of 325 deceased-donor renal allograft recipients, the patients were determined eli...

journal_title：Human immunology

authors： Vlad G,Ho EK,Vasilescu ER,Colovai AI,Stokes MB,Markowitz GS,D'Agati VD,Cohen DJ,Ratner LE,Suciu-Foca N

更新日期：2009-08-01 00:00:00

abstract：:Rat soluble MHC class I synthesis was studied at both RNA and protein levels to determine whether multiple forms of soluble MHC class I molecules are produced by different mechanisms. RT-PCR and sequencing of MHC class I transcripts identified an alternatively spliced nonclassical MHC class I gene product, lacking bot...

journal_title：Human immunology

authors： Zhai Y,Knechtle S

更新日期：1998-07-01 00:00:00

abstract：:We describe the production of mouse monoclonal antibodies specific for the human TcR using as the immunogen transfected murine T-cell hybridoma cells coexpressing mouse CD3 with human Jurkat TcR alpha and beta chains. The shortage of monoclonal antibodies (mAbs) specific for the human TcR-V alpha and V beta families r...

journal_title：Human immunology

authors： Zumla A,McCormack A,George A,Batchelor R,Lechler R

更新日期：1992-11-01 00:00:00

abstract：:CD8(+) T-cell responses to three human cytomegalovirus (CMV) pp65 epitopes were studied in panels of healthy seropositive HLA-A*02/HLA-B*07 individuals, and HLA-A*02 donors mismatched for HLA-B*07. The majority of the latter had significant responses to a HLA-A*02-restricted epitope within the CMV pp65 antigen. By con...

journal_title：Human immunology

authors： Lacey SF,Villacres MC,La Rosa C,Wang Z,Longmate J,Martinez J,Brewer JC,Mekhoubad S,Maas R,Leedom JM,Forman SJ,Zaia JA,Diamond DJ

更新日期：2003-04-01 00:00:00

abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtai...

journal_title：Human immunology

authors： Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Bravo-Acevedo A,Juárez-Nicolás F,Arriaga-Perea AJ,Vega-Martínez MDR,Ortega-Yáñez A,Benítez-Arvizu G,Arrieta-Bolaños E,Clayton S,Juárez-Cortés ED,López-Gil C,García-Álvarez R

更新日期：2020-09-01 00:00:00

abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...

journal_title：Human immunology

authors： Seshasubramanian V,Manisekar NK,Sathishkannan AD,Naganathan C,Narayan S

更新日期：2018-08-01 00:00:00

abstract：:Highly sensitized renal transplant candidates present a group at high risk for acute and chronic rejection. The probability of finding compatible donors for these recipients is significantly lower in comparison to those who have low PRA values. As a consequence, these patients spend longer time on the waiting list and...

journal_title：Human immunology

authors： Lobashevsky AL,Senkbeil RW,Shoaf JL,Stephenson AK,Skelton SB,Burke RM,Deierhoi MH,Thomas JM

更新日期：2002-05-01 00:00:00

abstract：:Cord blood, donated by mothers after the birth of their children, has become an accepted source of related and unrelated hematopoietic stem cells for marrow reconstitution. We estimate that some 7-8000 unrelated-donor cord blood transplants have been performed worldwide since 1993. The development of cord blood as a s...

journal_title：Human immunology

authors： Rubinstein P

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...

journal_title：Human immunology

authors： da Costa Lima Caniatti MC,Borelli SD,Guilherme AL,Tsuneto LT

更新日期：2017-02-01 00:00:00

abstract：:The purpose of this paper is to report a pedigree with hereditary hemochromatosis in which a recombination between the HLA-A and B loci occurred. Both the maternal and paternal HLA-A3, B7 haplotypes were carrying an allele for hemochromatosis. The A3, B12 haplotype of the proband was a recombinant of the maternal A3, ...

journal_title：Human immunology

authors： Edwards CQ,Cartwright GE,Skolnick MH,Amos DB

更新日期：1980-07-01 00:00:00

abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...

journal_title：Human immunology

authors： Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WH

更新日期：2016-09-01 00:00:00

abstract：:There are clinical situations in which it may be advantageous to monitor delayed type hypersensitivity (DTH) responses, an index of cell-mediated immunity, without exposing patients directly to the challenge antigens. For example, transplant patients may be at risk for becoming sensitized to donor antigens if injected...

journal_title：Human immunology

authors： Carrodeguas L,Orosz CG,Waldman WJ,Sedmak DD,Adams PW,VanBuskirk AM

更新日期：1999-08-01 00:00:00

abstract：:The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are still largely unknown. We have indicated that myeloid dendritic cells (M-DCs) and plasmacytoid dendritic cells (P-DCs) isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The ...

journal_title：Human immunology

authors： Penna G,Vulcano M,Sozzani S,Adorini L

更新日期：2002-12-01 00:00:00

abstract：:Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...

journal_title：Human immunology

authors： Chávez-Sánchez L,Madrid-Miller A,Chávez-Rueda K,Legorreta-Haquet MV,Tesoro-Cruz E,Blanco-Favela F

更新日期：2010-08-01 00:00:00

abstract：:Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...

journal_title：Human immunology

authors： Etessami S,Tarsitani C,Lias M,Broadous M,Conger N,Randol G,Delory M,Bahrami S,Lee JH

更新日期：2001-07-01 00:00:00

abstract：:NK cells play an important role in immune regulation and defense of infection, but their characteristics in patients with decompensated cirrhosis and their relationship with liver function remain unclear. We studied the functional properties of NK cells (including CD56dim NK and CD56bright NK cells) in patients with H...

journal_title：Human immunology

authors： Jiang Y,Chen Y,Chen L,Yao W,Guan J,Liu X,Wei X,Lin X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

journal_title：Human immunology

authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

更新日期：2020-12-01 00:00:00

abstract：:A two stage PCR-SSOP typing procedure, that permitted HLA-B allele assignment, was applied to DNA samples obtained from six diverse populations -Brazilian, Mexican (Series and Mestizos), Cuban (Caucasoid and Mulatto), South African Zulu, Omani, and Singapore Chinese. HLA-B allele frequencies and HLA-A/B two locus hapl...

journal_title：Human immunology

authors： Williams F,Meenagh A,Darke C,Acosta A,Daar AS,Gorodezky C,Hammond M,Nascimento E,Middleton D

更新日期：2001-06-01 00:00:00

abstract：:HLA-DQA1 typing of the 4AOHW cell panel is presented using a novel strategy that exploits both intron and exon polymorphisms. Intron sequences adjacent to the variable HLA-DQA1 second exon exhibit stable polymorphisms that are specific for locus alleles and certain suballelic DR/DQ haplotypes. A PCR-RFLP method has be...

journal_title：Human immunology

authors： Limm TM,Ashdown ML,Naughton MJ,McGinnis MD,Simons MJ

更新日期：1993-09-01 00:00:00

abstract：:We have studied HLA-DQ encoded antigens from HLA-DRw6 homozygous cells and analyzed the DQ region at the DNA level. HLA-DQ molecules were isolated from EBV transformed B-cell lines and analyzed for DQ alpha and DQ beta polymorphism. From the same set of cells, DNA was isolated and analyzed for RFLP. Polymorphism could...

journal_title：Human immunology

authors： Bosch ML,Fei H,Bontrop RE,Gerrets R,Tilanus MG,Termijtelen A,Giphart MJ

更新日期：1987-06-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) play an important role in the regulation and suppression of immune responses to self- and foreign antigens. Suppressed and impaired host immune responses are a major characteristic of many persistent human virus infections, such as those caused by human immunodeficiency virus (HIV), h...

journal_title：Human immunology

authors： Billerbeck E,Thimme R

更新日期：2008-11-01 00:00:00

abstract：:Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...

journal_title：Human immunology

authors： Lee KW,Jung YA

更新日期：2011-09-01 00:00:00

abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

journal_title：Human immunology

authors： Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

更新日期：2001-08-01 00:00:00

abstract：:More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...

journal_title：Human immunology

authors： Dankers MK,Roelen DL,Korfage N,de Lange P,Witvliet M,Sandkuijl L,Doxiadis II,Claas FH

更新日期：2003-06-01 00:00:00

abstract：:From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...

journal_title：Human immunology

authors： Ouwehand AJ,Vaessen LM,Baan CC,Jutte NH,Balk AH,Essed CE,Bos E,Claas FH,Weimar W

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS:We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS:Nineteen studies ...

journal_title：Human immunology

authors： Lee YH,Bae SC,Song GG

更新日期：2015-03-01 00:00:00

abstract：:Natural killer (NK) cells are key members of innate immunity against tumor and infection. Killer cell immunoglobulin-like receptor (KIR) genes regulates NK cell function, which varies substantially between individuals in the number and type. Specific KIRs are associated with certain diseases. Herein we investigated if...

journal_title：Human immunology

authors： Ashouri E,Dabbaghmanesh MH,Rowhanirad S,Bakhshayeshkaram M,Ranjbar Omrani G,Ghaderi A

更新日期：2012-10-01 00:00:00

abstract：:HLA typing was performed on 977 African Americans residing throughout most of the United States. Class I and class II antigens and class II alleles were defined for all individuals and class I alleles were determined for a subset of individuals. The occurrence of 854 of the individuals in family groups permitted direc...

journal_title：Human immunology

authors： Zachary AA,Bias WB,Johnson A,Rose SM,Leffell MS

更新日期：2001-10-01 00:00:00