Abstract：
:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients develop acute dysfunction with histological lesions suggestive of ABMR in the absence of anti-HLA DSAs. Although this non-HLA ABMR is not well recognized by current diagnostic classifications, it is associated with graft dysfunction and allograft loss. These clinical descriptions suggest a pathogenic role for non-HLA anti-endothelial cell antibodies. Diverse antigenic targets have been described during the last decade. This review discusses recent findings in the field and addresses the clinical relevance of anti-endothelial cell antibodies (AECAs).
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Delville M,Charreau B,Rabant M,Legendre C,Anglicheau Ddoi
10.1016/j.humimm.2016.05.021subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1055-1062issue
11eissn
0198-8859issn
1879-1166pii
S0198-8859(16)30105-7journal_volume
77pub_type
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