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Interleukin 10 gene single nucleotide polymorphisms in Polish patients with chronic hepatitis C: Analysis of association with severity of disease and treatment outcome.

Abstract：

:It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nucleotide polymorphisms (SNPs) of IL-10 gene with severity of liver disease (degree of inflammation and stage of fibrosis) and outcome of pegylated interferon alpha and ribavirin combined therapy (sustained virological response (SVR) and relapse) in 196 Polish CHC patients infected with HCV genotype 1. The analysis included IL-10 promoter SNPs: -1082(A/G) rs1800896, -819(C/T) rs1800871, -592(C/A) rs1800872 and SNP in the 3' UTR of IL-10 gene: +4529(A/G) rs3024498. Genotyping was performed using PCR-RFLP and HRM analysis. It was demonstrated that the -592C allele is associated with mild hepatic inflammation. Moreover, it was found that the -819C allele might be associated with SVR and that the ACCA haplotype and intermediate IL-10 producer ACC haplotype are associated with SVR and non-relapse. It can be concluded that IL-10 SNPs are associated with severity of disease and response to therapy and may be considered as potential prognostic and predictive markers in CHC.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Świątek-Kościelna B,Kałużna E,Strauss E,Januszkiewicz-Lewandowska D,Bereszyńska I,Wysocki J,Rembowska J,Barcińska D,Antosik D,Mozer-Lisewska I,Nowak J

doi

10.1016/j.humimm.2016.10.015

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

192-200

issue

2

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(16)30471-2

journal_volume

78

pub_type

杂志文章

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