TAP1 and TAP2 gene polymorphisms and HLA-TAP haplotypes in Koreans based on 90 families.

abstract：:The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, TIM-1, was considered as a membrane protein that is associated with the development of helper T cell (Th2) biased immune responses, and may be selectively expressed on Th2 cells....

journal_title：Human immunology

authors： Chae SC,Song JH,Heo JC,Lee YC,Kim JW,Chung HT

更新日期：2003-12-01 00:00:00

abstract：:Highly sensitized renal transplant candidates present a group at high risk for acute and chronic rejection. The probability of finding compatible donors for these recipients is significantly lower in comparison to those who have low PRA values. As a consequence, these patients spend longer time on the waiting list and...

journal_title：Human immunology

authors： Lobashevsky AL,Senkbeil RW,Shoaf JL,Stephenson AK,Skelton SB,Burke RM,Deierhoi MH,Thomas JM

更新日期：2002-05-01 00:00:00

abstract：:Based upon observations in murine models, we have developed protocols to induce renal allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility comple...

journal_title：Human immunology

authors： Sasaki H,Oura T,Spitzer TR,Chen YB,Madsen JC,Allan J,Sachs DH,Cosimi AB,Kawai T

更新日期：2018-05-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...

journal_title：Human immunology

authors： Sylvia T,Samuel M,Luis G,Zuzet M

更新日期：2013-08-01 00:00:00

abstract：:A new treatment approach, involving intense immunosuppression and autologous hematopoietic stem cell transplantation (SCT), has emerged in recent years for the treatment of severe, refractory rheumatic autoimmune diseases including rheumatoid arthritis (RA). The rationale of this strategy is based on the concept of im...

journal_title：Human immunology

authors： Verburg Ro,Toes RE,Fibbe WE,Breedveld FC,van Laar JM

更新日期：2002-08-01 00:00:00

abstract：:The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of He...

journal_title：Human immunology

authors： Cardozo DM,Marangon AV,da Silva RF,Aranha FJP,Visentainer JEL,Bonon SHA,Costa SCB,Miranda ECM,de Souza CA,Guimarães F

更新日期：2016-10-01 00:00:00

abstract：:In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...

journal_title：Human immunology

authors： Ford D,Hamblin A,Dumonde D,Burger D

更新日期：1982-06-01 00:00:00

abstract：:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...

journal_title：Human immunology

authors： Chen Q,Yan CQ,Liu FJ,Tong J,Miao SL,Chen JP

更新日期：2008-04-01 00:00:00

abstract：:4-Hydroxynonenal (HNE) is the most abundant and toxic aldehyde generated by the oxidation of plasma membrane polyunsaturated fatty acids. Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is primarily characterized by increased levels of autoantibodies, predominantly against ds-DNA. However, the initia...

journal_title：Human immunology

authors： Khatoon F,Moinuddin,Alam K,Ali A

更新日期：2012-11-01 00:00:00

abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...

journal_title：Human immunology

authors： Lee YJ,Woo M,Nam JH,Baek J,Im CH,Lee EY,Lee EB,Park KS,Song YW

更新日期：2008-06-01 00:00:00

abstract：:The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...

journal_title：Human immunology

authors： Malheiro J,Tafulo S,Dias L,Martins S,Fonseca I,Beirão I,Castro-Henriques A,Cabrita A

更新日期：2017-09-01 00:00:00

abstract：:Monoclonal antibodies have played an important role in studying the biochemistry of the HLA-Class I molecules. Some murine anti-HLA mAbs can identify configurations of HLA epitopes that have never been reported in human allosera. One of these configurations is identified by an IgM mAb designated as: BHA-1441. This ant...

journal_title：Human immunology

authors： Etessami S,Tarsitani C,Lias M,Broadous M,Conger N,Randol G,Delory M,Bahrami S,Lee JH

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...

journal_title：Human immunology

authors： da Costa Lima Caniatti MC,Borelli SD,Guilherme AL,Tsuneto LT

更新日期：2017-02-01 00:00:00

abstract：:Induced Treg with the phenotype CD4(+)CD25(+)Foxp3(+)IFNγ(+) were shown to be associated with good long-term graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute to the inh...

journal_title：Human immunology

authors： Daniel V,Sadeghi M,Wang H,Opelz G

更新日期：2013-02-01 00:00:00

abstract：:Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

journal_title：Human immunology

authors： Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

更新日期：1994-01-01 00:00:00

abstract：:Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...

journal_title：Human immunology

authors： Kay PH,Dawkins RL,Williamson J,Tokunaga K,Christiansen FT,Charoenwong P

更新日期：1988-09-01 00:00:00

abstract：:The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...

journal_title：Human immunology

authors： Carbonara AO,DeMarchi M,van Loghem E,Ansaldi N

更新日期：1983-02-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). METHODS:A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA),...

journal_title：Human immunology

authors： Song GG,Choi SJ,Ji JD,Lee YH

更新日期：2012-10-01 00:00:00

abstract：:HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...

journal_title：Human immunology

authors： Gunathilake KM,Wettasinghe KT,Dissanayake VH

更新日期：2016-05-01 00:00:00

abstract：:This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft. ...

journal_title：Human immunology

authors： Chan-On C,Liberto JM,Sarwal MM

更新日期：2018-05-01 00:00:00

abstract：:Oxidized low-density lipoproteins and Toll-like receptors (TLR) 2 and 4 are involved in the development of atherosclerosis. The TLR are important in the pro-inflammatory response. The aim of this research was to analyze the activation of CD14, TLR4, and TLR2 in response to minimally modified low-density lipoprotein (m...

journal_title：Human immunology

authors： Chávez-Sánchez L,Madrid-Miller A,Chávez-Rueda K,Legorreta-Haquet MV,Tesoro-Cruz E,Blanco-Favela F

更新日期：2010-08-01 00:00:00

abstract：:There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...

journal_title：Human immunology

authors： Aultman D,Adamashvili I,Yaturu K,Langford M,Gelder F,Gautreaux M,Ghali GE,McDonald J

更新日期：1999-03-01 00:00:00

abstract：:Comparison of human leukocyte antigen (HLA) frequencies in patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and in patients with HCV-associated non-Hodgkin's lymphoma (NHL) has not been addressed previously. To this aim, we investigated the distribution of HLA class II alleles in two sel...

journal_title：Human immunology

authors： De Re V,Caggiari L,Talamini R,Crovatto M,De Vita S,Mazzaro C,Cannizzaro R,Dolcetti R,Boiocchi M

更新日期：2004-11-01 00:00:00

abstract：:To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase ...

journal_title：Human immunology

authors： Sugimura K,Asakura H,Mizuki N,Inoue M,Hibi T,Yagita A,Tsuji K,Inoko H

更新日期：1993-02-01 00:00:00

abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

journal_title：Human immunology

authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

更新日期：1989-09-01 00:00:00

abstract：:Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

journal_title：Human immunology

authors： Dean RR,Kilduff TS,Dement WC,Grumet FC

更新日期：1989-05-01 00:00:00

abstract：:In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...

journal_title：Human immunology

authors： Radka SF,Scott RG,Stewart SJ

更新日期：1987-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...

journal_title：Human immunology

authors： Zozulya AL,Wiendl H

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVES:The tumour necrosis factor superfamily 4 (TNFSF4) is a candidate gene for autoimmune diseases. We investigated the relationship of this gene with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in a Chinese Guangxi population. METHODS:A total of 294 patients with SLE, 210 with RA, and 282 h...

journal_title：Human immunology

authors： Xu J,He Y,Wang J,Li X,Huang L,Li S,Qin X

更新日期：2019-04-01 00:00:00

abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

journal_title：Human immunology

authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

更新日期：2013-12-01 00:00:00