Abstract：
:Based upon observations in murine models, we have developed protocols to induce renal allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility complex (MHC)-mismatched primates, with detectable chimerism typically disappearing within 30-60 days. Nevertheless, in MHC mismatched NHP, long-term immunosuppression-free renal allograft survival has been achieved reproducibly, using a non-myeloablative conditioning approach that has also been successfully extended to human kidney transplant recipients. CKBMT has also been applied to the patients with end stage renal disease with hematologic malignancies. Renal allograft tolerance and long-term remission of myeloma have been achieved by transient mixed or persistent full chimerism. This review summarizes the current status of preclinical and clinical studies for renal and non-renal allograft tolerance induction by CKBMT. Improving the consistency of tolerance induction with less morbidity, extending this approach to deceased donor transplantation and inducing tolerance of non-renal transplants, are critical next steps for bringing this strategy to a wider range of clinical applications.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Sasaki H,Oura T,Spitzer TR,Chen YB,Madsen JC,Allan J,Sachs DH,Cosimi AB,Kawai Tdoi
10.1016/j.humimm.2017.11.008subject
Has Abstractpub_date
2018-05-01 00:00:00pages
258-265issue
5eissn
0198-8859issn
1879-1166pii
S0198-8859(17)30549-9journal_volume
79pub_type
杂志文章,评审相关文献
HUMAN IMMUNOLOGY文献大全abstract：:We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.07.001
更新日期：2005-09-01 00:00:00
abstract：:It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.05.004
更新日期：2009-09-01 00:00:00
abstract：:The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(98)00059-7
更新日期：1998-09-01 00:00:00
abstract：:The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...
journal_title：Human immunology
pub_type： 杂志文章,meta分析
doi：10.1016/j.humimm.2014.09.005
更新日期：2014-12-01 00:00:00
abstract：:The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.03.010
更新日期：2015-05-01 00:00:00
abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2003.12.014
更新日期：2004-04-01 00:00:00
abstract：:Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(88)90015-8
更新日期：1988-09-01 00:00:00
abstract：:It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00128-7
更新日期：2000-03-01 00:00:00
abstract：:Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5 (CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) and therefore preferred stem cell donors for HIV-infected patients. We analyzed CCR5 typing data of 1,333,035 potential hematopoietic stem cell don...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2017.10.001
更新日期：2017-11-01 00:00:00
abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2019.01.001
更新日期：2019-03-01 00:00:00
abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.10.002
更新日期：2020-12-01 00:00:00
abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2014.04.002
更新日期：2014-06-01 00:00:00
abstract：:It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nuc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.10.015
更新日期：2017-02-01 00:00:00
abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00107-4
更新日期：1999-02-01 00:00:00
abstract：:This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, M...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(95)00175-1
更新日期：1996-03-01 00:00:00
abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00152-g
更新日期：1995-07-01 00:00:00
abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.01.029
更新日期：2013-05-01 00:00:00
abstract：:To calculate reliable HLA gene and haplotype frequencies of bone marrow donors in various regions in the world, we have analyzed the HLA-A, -B, and -DR phenotype frequencies of 18 bone marrow donor registries with a total of more than 300,000 HLA-A, -B-typed donors. These registries were included in the 22nd edition o...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(96)00257-1
更新日期：1997-01-01 00:00:00
abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(98)00075-5
更新日期：1998-11-01 00:00:00
abstract：:T-cell clonal anergy induced by peptide analogs in the presence of live APC in murine systems was reported to be associated with incomplete tyrosine phosphorylation of the CD3 zeta chain followed by a lack of subsequent ZAP-70 recruitment. Furthermore, protein tyrosine phosphatase SHP-1 was associated with ZAP-70 upon...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/S0198-8859(96)00273-X
更新日期：1997-03-01 00:00:00
abstract：:From a human cDNA library constructed from consanguineous HLA-homozygous cell line AKIBA (HLA-A24, Bw52, DR2, Dw12, Cp63 Cp63: a new DP type), cDNA clones encoding the heavy and light chains of an HLA-DP Cp63 alloantigen were isolated and analyzed by restriction enzyme mapping and nucleotide sequence determination. Al...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(86)90286-7
更新日期：1986-11-01 00:00:00
abstract：:The purpose of this article is to study the amounts of gamma-aminobutyric acid-transaminase (GABA-t) during immune response in the human thymus. GABA-t was studied by biochemical and histochemical methods in 7 immunostimulated (treated) and 7 non-immunostimulated (untreated) patients (4 young adult, age range: 24-36 y...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(00)00130-0
更新日期：2000-07-01 00:00:00
abstract：:A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.05.004
更新日期：2019-07-01 00:00:00
abstract：:This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft. ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2018.01.016
更新日期：2018-05-01 00:00:00
abstract：:The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association ana...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.09.005
更新日期：2018-11-01 00:00:00
abstract：:Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.02.001
更新日期：2009-04-01 00:00:00
abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90183-2
更新日期：1993-07-01 00:00:00
abstract：:Indirect immunofluorescence staining with monoclonal antibodies has shown a differential distribution of HLA-DR, DQ, and DP antigens in normal tissues of nonlymphoid origin. The distribution of HLA-DP antigens is similar to that of HLA-DR antigens, while that of HLA-DQ antigens is more restricted. Malignant transforma...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(86)90028-5
更新日期：1986-02-01 00:00:00
abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90023-i
更新日期：1990-06-01 00:00:00
abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(03)00041-7
更新日期：2003-05-01 00:00:00
