Abstract：
:To calculate reliable HLA gene and haplotype frequencies of bone marrow donors in various regions in the world, we have analyzed the HLA-A, -B, and -DR phenotype frequencies of 18 bone marrow donor registries with a total of more than 300,000 HLA-A, -B-typed donors. These registries were included in the 22nd edition of Bone Marrow Donors Worldwide. Maximum likelihood gene frequencies, Hardy-Weinberg equilibrium fit, and 2- and 3-locus haplotype frequencies were calculated as well as deltas, relative deltas, and their significance. Remarkable gene and haplotype frequency differences exist between the registries. The genetic distances between the different registries were used to draw phylogenetic trees that clearly show that the degree of similarity between registries is related to their geographic locations. The resulting frequencies can be used for the estimation of the probability of finding a hyplotypically identical related or unrelated bone marrow donor for an individual patient. Phylogenetic trees are useful representations of the similarity between donor pools and can also aid in the selection of donors.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Schipper RF,D'Amaro J,Bakker JT,Bakker J,van Rood JJ,Oudshoorn Mdoi
10.1016/s0198-8859(96)00257-1subject
Has Abstractpub_date
1997-01-01 00:00:00pages
54-71issue
1eissn
0198-8859issn
1879-1166pii
S0198885996002571journal_volume
52pub_type
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