Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco.

abstract：:The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-ant...

journal_title：Human immunology

authors： Hachem RR

更新日期：2019-08-01 00:00:00

abstract：:Detection and avoidance of donor-reactive antibodies in the sera of potential organ transplant recipients is key to a successful transplant outcome. Techniques of antibody detection that use flow cytometry are more sensitive than those that rely upon a visual determination of cytotoxicity. However, as conventionally p...

journal_title：Human immunology

authors： Wetzsteon PJ,Head MA,Fletcher LM,Lye WC,Norman DJ

更新日期：1992-10-01 00:00:00

abstract：:The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...

journal_title：Human immunology

authors： Martell RW,Oudshoorn M,Arendse B,du Toit ED

更新日期：1990-05-01 00:00:00

abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...

journal_title：Human immunology

authors： Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MG

更新日期：2000-10-01 00:00:00

abstract：:Identification of mycobacterial antigens that are recognized by CD4+ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases. Our studies in this direction have shown that several recombinant mycobacteri...

journal_title：Human immunology

authors： Mustafa AS

更新日期：2000-02-01 00:00:00

abstract：:Uninfected, as well as feline leukemia virus (FeLV) infected human cells cultured under high cell density conditions undergo changes in the expression of major histocompatibility complex (MHC) antigens, as determined by indirect trace binding radio immunoassay (RIA) using monoclonal anti-HLA antibodies and by decrease...

journal_title：Human immunology

authors： Azocar J,Essex M,Yunis EJ

更新日期：1983-06-01 00:00:00

abstract：:Besides central tolerance peripheral tolerance is an important mechanism to avoid development of autoimmunity. Naturally occurring thymic-derived regulatory T cells (nTreg) mediate peripheral tolerance by suppressing autoreactive T cells clones having escaped thymic deletional control. This implies that nTreg have the...

journal_title：Human immunology

authors： Hadaschik EN,Enk AH

更新日期：2015-08-01 00:00:00

abstract：:Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...

journal_title：Human immunology

authors： Gedde-Dahl T 3rd,Eriksen JA,Thorsby E,Gaudernack G

更新日期：1992-04-01 00:00:00

abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...

journal_title：Human immunology

authors： Mickelson EM,Petersdorf E,Anasetti C,Martin P,Woolfrey A,Hansen JA

更新日期：2000-02-01 00:00:00

abstract：:In attempts to examine the relationships between serologic and structural polymorphisms of HLA-DQ molecules we have analyzed several monoclonal antibodies generated against polymorphic determinants on HLA-DQ molecules. One antibody, SFR20-DQw3, has a serologic reactivity like that of the previously characterized anti-...

journal_title：Human immunology

authors： Radka SF,Scott RG,Stewart SJ

更新日期：1987-04-01 00:00:00

abstract：:The Fas-FasL system plays a crucial role in the maintenance of homeostasis in the immune system. To characterize the Fas/FasL system in macaque monkeys that are commonly used as experimental primates, we cloned and sequenced Fas cDNA derived from the cynomolgus monkey. The predicted amino acid sequence consists of 331...

journal_title：Human immunology

authors： Murayama Y,Terao K,Inoue-Murayama M

更新日期：2000-05-01 00:00:00

abstract：:The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. How...

journal_title：Human immunology

authors： Lundberg K,Greiff L,Borrebaeck CA,Lindstedt M

更新日期：2010-10-01 00:00:00

abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

journal_title：Human immunology

authors： Perry RT,Nyaku MK,Aissani B,Shrestha S

更新日期：2014-08-01 00:00:00

abstract：:We previously investigated the characteristics of renal allograft infiltrating T-cell lines that were propagated from biopsy and nephrectomy specimens designated as IG-Bip and IG-Neph, respectively, or analogous line designated IG-T-eff, which was generated by co-culturing pretransplant recipient blood with irradiated...

journal_title：Human immunology

authors： Emara MA,Mozes MF

更新日期：1995-02-01 00:00:00

abstract：:Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether ...

journal_title：Human immunology

authors： Grimaldi V,Sommese L,Picascia A,Casamassimi A,Cacciatore F,Renda A,De Rosa P,Montesano ML,Sabia C,Fiorito C,De Iorio G,Napoli C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...

journal_title：Human immunology

authors： Mine KL,Tedesco-Silva H,Mourão TB,Campos EF,Salzedas LA,Aguiar B,Felipe CR,Medina-Pestana JO,Gerbase-DeLima M

更新日期：2018-08-01 00:00:00

abstract：:CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was design...

journal_title：Human immunology

authors： Chauhan B,Hutcheson PS,Slavin RG,Bellone CJ

更新日期：2002-04-01 00:00:00

abstract：:In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...

journal_title：Human immunology

authors： Toussirot E,Sauvageot C,Chabod J,Ferrand C,Tiberghien P,Wendling D

更新日期：2000-03-01 00:00:00

abstract：:The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...

journal_title：Human immunology

authors： Müller C,Herbst H,Uchanska-Ziegler B,Ziegler A,Schunter F,Steiert I,Muller C,Wernet P

更新日期：1985-12-01 00:00:00

abstract：:There is considerable current interest in the application of Southern blotting and hybridization, with locus-specific HLA class II probes, to HLA typing. The work of several laboratories has shown that, under suitable conditions, restriction fragment patterns that correlate with DR and DQ serology and with DP cellular...

journal_title：Human immunology

authors： Bangham CR,Bushell A,Wood KJ,Morris PJ

更新日期：1988-02-01 00:00:00

abstract：:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

journal_title：Human immunology

authors： Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

更新日期：1989-11-01 00:00:00

abstract：:Three monoclonal antibodies have been used to isolate Ia-like antigens from three human cell lines; two of which are thought to be homozygous at the HLA-D/DR locus. Complete extraction of the Ia antigens identified by one antibody leaves those recognized by the two remaining antibodies in three parallel sets of experi...

journal_title：Human immunology

authors： Pesando JM,Nadler LM,Lazarus H,Tomaselli KJ,Stashenko P,Ritz J,Levine H,Yunis EJ,Schlossman SF

更新日期：1981-08-01 00:00:00

abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

journal_title：Human immunology

authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

更新日期：1990-02-01 00:00:00

abstract：:This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...

journal_title：Human immunology

authors： Lindemann M,Dioury Y,Beckebaum S,Cicinnati VR,Gerken G,Broelsch CE,Wrighton-Smith P,Grosse-Wilde H

更新日期：2009-01-01 00:00:00

abstract：:The suppressive effects of CD4+CD25+ regulatory T cells (Tregs) on T cells have been well documented. Here we investigated whether human CD4+CD25+ Tregs can inhibit the proinflammatory properties of monocytes/macrophages. Monocytes and T cells were isolated from peripheral blood of healthy volunteers by magnetic cell ...

journal_title：Human immunology

authors： Taams LS,van Amelsfort JM,Tiemessen MM,Jacobs KM,de Jong EC,Akbar AN,Bijlsma JW,Lafeber FP

更新日期：2005-03-01 00:00:00

abstract：:The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, TIM-1, was considered as a membrane protein that is associated with the development of helper T cell (Th2) biased immune responses, and may be selectively expressed on Th2 cells....

journal_title：Human immunology

authors： Chae SC,Song JH,Heo JC,Lee YC,Kim JW,Chung HT

更新日期：2003-12-01 00:00:00

abstract：:Genomic aberrations in the CREBBP (CREB-binding protein - CREBBP or CBP) gene such as point mutations, small insertions or exonic copy number changes are usually associated with Rubinstein-Taybi syndrome (RTs). In this study, the disruption of the CREBBP gene on chromosome 16p13.3, as revealed by CGH-array and FISH, s...

journal_title：Human immunology

authors： Torres LC,Kulikowski LD,Ramos PL,Sugayama SM,Moreira-Filho CA,Carneiro-Sampaio M

更新日期：2013-08-01 00:00:00

abstract：:To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...

journal_title：Human immunology

authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Laitinen I,Kotilainen P,Rajamäki A,Nikoskelainen J,Lilius EM

更新日期：2009-04-01 00:00:00

abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

journal_title：Human immunology

authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

更新日期：1999-01-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...

journal_title：Human immunology

authors： Papp M,Lakatos PL,Harsfalvi J,Farkas G,Palatka K,Udvardy M,Molnar T,Farkas K,Nagy F,Veres G,Lakatos L,Kovacs A,Dinya T,Kocsis AK,Papp J,Hungarian IBD Study Group.,Altorjay I

更新日期：2010-04-01 00:00:00