Partial N-terminal sequence analysis of human class II molecules expressing the DQw3 determinant.

Abstract:

:HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of murine I-A molecules. Within the limits of our sequence analysis, the DQw3 molecules from the two cell lines are identical to each other in both the alpha and beta chains. The DQ alpha as well as DQ beta chains were found to have amino acid substitutions when compared to other I-A-like molecules whose sequences have been reported. These differences may contribute to the DQw supertypic specificity. The polymorphic nature of DQ molecules is in marked contrast to that of DR molecules where DR alpha chains are highly conserved while DR beta chains have easily detectable amino acid substitutions.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Obata F,Endo T,Yoshii M,Otani F,Igarashi M,Takenouchi T,Ikeda H,Ogasawara K,Kasahara M,Wakisaka A

doi

10.1016/0198-8859(85)90061-8

subject

Has Abstract,Author List Incomplete

pub_date

1985-09-01 00:00:00

pages

19-27

issue

1

eissn

0198-8859

issn

1879-1166

pii

0198-8859(85)90061-8

journal_volume

14

pub_type

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