The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18.

Abstract:

:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated from DR1 by gene conversion with DR4-Dw10, DR5, or DRw6-Dw18 third hypervariable region sequences.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

doi

10.1016/0198-8859(89)90038-4

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

191-7

issue

3

eissn

0198-8859

issn

1879-1166

pii

0198-8859(89)90038-4

journal_volume

26

pub_type

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