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A novel DR beta 1*03 allele identified by polymerase chain reaction-restriction fragment length polymorphism.

Abstract：

:This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, Msp I, Hha I, Bse RI, Mnl I, Hph I, and Bsrb I gave banding patterns expected for a DR beta 1*03011 allele, but Rsa I had an additional site at codon 47. Sequencing showed a single base change at this position, with the substitution of tyrosine for phenylanine in this new allele. The biologic impact of this substitution remains to be determined.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Fenske B,Lemieux J,Hoar D,Fitzpatrick J,Keown P

doi

10.1016/0198-8859(95)00175-1

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

55-7

issue

1

eissn

0198-8859

issn

1879-1166

pii

0198885995001751

journal_volume

46

pub_type

杂志文章

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