Abstract:
:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with Con-A-stimulated lymphocyte supernatants, an increase in HLA-A, B, C, and DR staining was observed. No increase was noted when two other monoclonal antibodies against non-HLA-related monocyte antigens (63D3 and 61D3) were studied under the same culture conditions. These results indicate that soluble factor(s) present in Con-A-stimulated lymphocyte supernatants modulate the expression of the major histocompatibility antigens on the surface of human monocytes.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Nunez G,Stastny Pdoi
10.1016/0198-8859(83)90069-1subject
Has Abstractpub_date
1983-01-01 00:00:00pages
1-11issue
1eissn
0198-8859issn
1879-1166pii
0198-8859(83)90069-1journal_volume
6pub_type
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